Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients

QR Code

Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients

Objective: To provide quick and accurate clinical diagnostic tools those are currently not available leading to improper management of colorectal cancer (CRC) patients. Methods: The metabolomic profiles of 10 CRC patients treated with 5-fluorouracil and 24 healthy volunteers were analysed. The subje...

Full description

Bibliographic Details
Main Authors:	Bannur, Zakaria, Salleh, Mohd Zaki, Hashim, H., Hennessy, Thomas, Azmi, M. N., Zailani, M. H., Ramasamy, P., Zakaria, Zainul Amiruddin, Suneet, S., Abdullah, Harris Ngow, Henry, G., Teh, Lay Kek
Format:	Article
Language:	English
Published:	Innovare Academic Sciences 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/34497/ http://psasir.upm.edu.my/id/eprint/34497/1/Metabolomics%20and%20pharmacogenetics%20based%205-fluorouracil%20monitoring%20in%20colorectal%20cancer%20patients.pdf

Similar Items

Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
by: Zakaria, Bannur, et al.
Published: (2014)

Potential of dihydropyrimidine dehydrogenase genotypes in personalising 5-fluorouracil therapy among colorectal cancer patients
by: Ngow, Harris Abdullah, et al.
Published: (2011)

Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients
by: Teh, Lay Kek, et al.
Published: (2013)

Integrating pharmacogenomics- metabolomics towards realising personalised medicine for colorectal cancer patients treated with 5-fluorouracil / Hazwanie Hashim
by: Hashim, Hazwanie
Published: (2012)

Cancerpharmacogenomics: the relevance of genetic profile in optimization drug therapy for azathiopurine and 5-Fluorouracil / Teh Lay Kek And Mohd Zaki Salleh
by: Teh, Lay Kek, et al.
Published: (2010)

Genetic polymorphism of drug metabolizing enzymes and estrogen receptor in pharmacogenetics of tamoxifen: implication for optimization of breast cancer treatment / Teh Lay Kek and Mohd Zaki Salleh
by: Lay Kek, Teh, et al.
Published: (2010)

The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach
by: Bannur, Zakaria, et al.
Published: (2014)

The role of pharmacogenetic variation in metoprolol CYP2D6 genotypes polymorphism
by: Wan Sulaiman, Wan Mohd. Azizi, et al.
Published: (2011)

Cancer pharmacogenomics: the relevance of genetic profile in optimization drug therapy for azathiopurine and 5-fluorouracil / Prof Madya Dr Teh Lay Kek and Prof Dr Mohd Zaki Salleh
by: Teh, Lay Kek, et al.
Published: (2010)

5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
by: Yusefi, Mostafa, et al.
Published: (2021)

Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek
by: Salleh, Mohd Zaki, et al.
Published: (2010)

Single nucleotide polymorphism (SNPS) analysis of Mu-opioid receptors (OPRM1) using denaturing high performance liquid chromatography (DHPLC) among the intravenous drug users
by: Teh, Lay Kek, et al.
Published: (2014)

Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development
by: Akkari, Patrick, et al.
Published: (2009)

Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients
by: Candy, P., et al.
Published: (2013)

Variability in responses of tacrolimus in kidney transplant patients: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practices / Sharina Hamzah
by: Hamzah, Sharina
Published: (2013)

Pharmacogenetics, pharmacogenomics and airway disease
by: Hall, Ian P.
Published: (2002)

5-Fluorouracil encapsulated chitosan-cellulose fiber bionanocomposites: Synthesis, characterization and in vitro analysis towards colorectal cancer cells
by: Yusefi, Mostafa, et al.
Published: (2021)

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia
by: Ware, James S., et al.
Published: (2017)

Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
by: Mohamed, Nor Izwani
Published: (2017)

A systematic review of the adverse effects of tacrolimus in organ transplant patients .
by: Teh, Lay Kek, et al.
Published: (2011)

Pharmacogenetics in cardiovascular disorders: An update on the principal drugs
by: Predazzi, I., et al.
Published: (2013)

Pharmacogenetics of beta adrenergic blockers: their clinical significance
by: Elsayed, Tarek Mohamed Ali
Published: (2009)

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy
by: Collura, A., et al.
Published: (2014)

Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats
by: Zakaria, Zainul Amiruddin, et al.
Published: (2020)

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
by: Soong, R., et al.
Published: (2008)

The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics
by: Amin, Arwa M., et al.
Published: (2017)

5-Fluorouracil induce the expression of TLR4 on HCT116 colorectal cancer cell line expressing different variants of TLR4
by: Davoodi, Homa, et al.
Published: (2013)

Lack of correlation between INR and warfarin dose: a role of pharmacogenotyping of CYP2C9*3 and VKORC1 for anticoagulation
by: Salleh, Mohd Zaki, et al.
Published: (2009)

VKORC1 Haplotypes in patients treated with warfarin
by: Beshna, E, et al.
Published: (2010)

Green synthesis of Fe3O4 nanoparticles for hyperthermia, magnetic resonance imaging and 5-fluorouracil carrier in potential colorectal cancer treatment
by: Yusefi, Mostafa, et al.
Published: (2021)

Mutational analysis of CYP2C8 in hypertensive patients using denaturing high performance liquid chromatography.
by: Teh, Lay Kek, et al.
Published: (2010)

Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequencies
by: Loh, M., et al.
Published: (2013)

Aqueous partition of methanolic extract of Dicranopteris linearis leaves protects against liver damage induced by paracetamol
by: Zakaria, Zainul Amiruddin, et al.
Published: (2019)

Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves
by: Zakaria, Zainul Amiruddin, et al.
Published: (2015)

Antinociceptive effect of semi-purified petroleum ether extract derived from crude methanol extract of muntingia calabura and its possible mechanisms of action
by: Zakaria, Zainul Amiruddin, et al.
Published: (2016)

Chitosan-Nanoparticles As A Drug Delivery System For 5-Fluorouracil
by: Suardi, Muslim
Published: (2003)

Utility of pharmacogenetic testing to optimise antidepressant pharmacotherapy in youth: a narrative literature review
by: Roberts, B., et al.
Published: (2023)

A Clinical And Pharmacogenetic Investigation Of Methadone Maintenance Therapy (MMT) In Opiate Dependent Individuals
by: Mohamad, Nasir
Published: (2011)

The Thermal Stability of Lattice-Energy Minima of 5-Fluorouracil: Metadynamics as an Aid to Polymorph Prediction
by: Karamertzanis, P., et al.
Published: (2008)

Physical pegylation enhances the cytotoxicity of 5-fluorouracil-loaded PLGA And PCL nanoparticles.
by: Ashour, Abdelkader Elbadawy Abbas, et al.
Published: (2019)