Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, antiinflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions....
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| Format: | Article |
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Asian Pacific Education Press Ltd.
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34405/ |
| _version_ | 1848847763465306112 |
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| author | Pandurangan, Ashok Kumar Mohd Esa, Norhaizan |
| author_facet | Pandurangan, Ashok Kumar Mohd Esa, Norhaizan |
| author_sort | Pandurangan, Ashok Kumar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids
that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, antiinflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC. |
| first_indexed | 2025-11-15T09:23:46Z |
| format | Article |
| id | upm-34405 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:23:46Z |
| publishDate | 2014 |
| publisher | Asian Pacific Education Press Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-344052015-12-15T01:05:00Z http://psasir.upm.edu.my/id/eprint/34405/ Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review Pandurangan, Ashok Kumar Mohd Esa, Norhaizan Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, antiinflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC. Asian Pacific Education Press Ltd. 2014 Article NonPeerReviewed Pandurangan, Ashok Kumar and Mohd Esa, Norhaizan (2014) Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review. Asian Pacific Journal of Cancer Prevention, 15 (14). pp. 5501-5508. ISSN 1513-7368 http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:25081655&key=2014.15.14.5501 10.7314/APJCP.2014.15.14.5501 |
| spellingShingle | Pandurangan, Ashok Kumar Mohd Esa, Norhaizan Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| title | Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| title_full | Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| title_fullStr | Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| title_full_unstemmed | Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| title_short | Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| title_sort | luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review |
| url | http://psasir.upm.edu.my/id/eprint/34405/ http://psasir.upm.edu.my/id/eprint/34405/ http://psasir.upm.edu.my/id/eprint/34405/ |