Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT
Background: To our knowledge, data are lacking on the role of 18F-FDG PET/CT in the localization and prediction of neuroendocrine tumors, in particular the pheochromocytoma/paraganglioma (PCC/PGL) group. Purpose: To evaluate the role of 18F-FDG PET/CT in localizing and predicting the malignant poten...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Foundation Acta Radiologica
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34396/ http://psasir.upm.edu.my/id/eprint/34396/1/Localization%20and%20prediction%20of%20malignant%20potential%20in%20recurrent.pdf |
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| author | Ahmad Saad, Fathinul Fikri Kroiss, Alexander Azman, Ahmad Zaid Fattah Hussein, Zanariah Lau, Eddie Wing Fai Uprimny, Christian Donnemiller, Eveline Kendler, Dorota Nordin, Abdul Jalil Virgolini, Irene J. |
| author_facet | Ahmad Saad, Fathinul Fikri Kroiss, Alexander Azman, Ahmad Zaid Fattah Hussein, Zanariah Lau, Eddie Wing Fai Uprimny, Christian Donnemiller, Eveline Kendler, Dorota Nordin, Abdul Jalil Virgolini, Irene J. |
| author_sort | Ahmad Saad, Fathinul Fikri |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: To our knowledge, data are lacking on the role of 18F-FDG PET/CT in the localization and prediction of neuroendocrine tumors, in particular the pheochromocytoma/paraganglioma (PCC/PGL) group. Purpose: To evaluate the role of 18F-FDG PET/CT in localizing and predicting the malignant potential of PCC/PGL. Material and Methods: Twenty-three consecutive patients with a history of PCC/PGL, presenting with symptoms related to catecholamine excess, underwent 18F-FDG PET/CT. Final confirmation of the diagnosis was made using the composite references. PET/CT findings were analyzed on a per-lesion basis and a per-patient basis. Tumor SUVmax was analyzed to predict the dichotomization of patient endpoints for the local disease and metastatic groups. Results: We investigated 23 patients (10 men, 13 women) with a mean age of 46.43±3.70 years. Serum catecholamine levels were elevated in 82.60% of these patients. There were 136 sites (mean SUVmax: 16.39±3.47) of validated disease recurrence. The overall sensitivities for diagnostic CT, FDG PET, and FDG PET/CT were 86.02%, 87.50%, and 98.59%, respectively. Based on the composite references, 39.10% of patients had local disease. There were significant differences in the SUVmax distribution between the local disease and metastatic groups; a significant correlation was noted when a SUVmax cut-off was set at 9.2 (P<0.05). Conclusion: In recurrent PCC/PGL, diagnostic 18F-FDG PET/CT is a superior tool in the localization of recurrent tumors. Tumor SUVmax is a potentially useful predictor of malignant tumor potential. |
| first_indexed | 2025-11-15T09:23:44Z |
| format | Article |
| id | upm-34396 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:23:44Z |
| publishDate | 2014 |
| publisher | The Foundation Acta Radiologica |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-343962016-09-15T07:13:28Z http://psasir.upm.edu.my/id/eprint/34396/ Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT Ahmad Saad, Fathinul Fikri Kroiss, Alexander Azman, Ahmad Zaid Fattah Hussein, Zanariah Lau, Eddie Wing Fai Uprimny, Christian Donnemiller, Eveline Kendler, Dorota Nordin, Abdul Jalil Virgolini, Irene J. Background: To our knowledge, data are lacking on the role of 18F-FDG PET/CT in the localization and prediction of neuroendocrine tumors, in particular the pheochromocytoma/paraganglioma (PCC/PGL) group. Purpose: To evaluate the role of 18F-FDG PET/CT in localizing and predicting the malignant potential of PCC/PGL. Material and Methods: Twenty-three consecutive patients with a history of PCC/PGL, presenting with symptoms related to catecholamine excess, underwent 18F-FDG PET/CT. Final confirmation of the diagnosis was made using the composite references. PET/CT findings were analyzed on a per-lesion basis and a per-patient basis. Tumor SUVmax was analyzed to predict the dichotomization of patient endpoints for the local disease and metastatic groups. Results: We investigated 23 patients (10 men, 13 women) with a mean age of 46.43±3.70 years. Serum catecholamine levels were elevated in 82.60% of these patients. There were 136 sites (mean SUVmax: 16.39±3.47) of validated disease recurrence. The overall sensitivities for diagnostic CT, FDG PET, and FDG PET/CT were 86.02%, 87.50%, and 98.59%, respectively. Based on the composite references, 39.10% of patients had local disease. There were significant differences in the SUVmax distribution between the local disease and metastatic groups; a significant correlation was noted when a SUVmax cut-off was set at 9.2 (P<0.05). Conclusion: In recurrent PCC/PGL, diagnostic 18F-FDG PET/CT is a superior tool in the localization of recurrent tumors. Tumor SUVmax is a potentially useful predictor of malignant tumor potential. The Foundation Acta Radiologica 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34396/1/Localization%20and%20prediction%20of%20malignant%20potential%20in%20recurrent.pdf Ahmad Saad, Fathinul Fikri and Kroiss, Alexander and Azman, Ahmad Zaid Fattah and Hussein, Zanariah and Lau, Eddie Wing Fai and Uprimny, Christian and Donnemiller, Eveline and Kendler, Dorota and Nordin, Abdul Jalil and Virgolini, Irene J. (2014) Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT. Acta Radiologica, 55 (5). pp. 631-640. ISSN 0284-1851; ESSN: 1600-0455 http://acr.sagepub.com/content/55/5/631.abstract 10.1177/0284185113504330 |
| spellingShingle | Ahmad Saad, Fathinul Fikri Kroiss, Alexander Azman, Ahmad Zaid Fattah Hussein, Zanariah Lau, Eddie Wing Fai Uprimny, Christian Donnemiller, Eveline Kendler, Dorota Nordin, Abdul Jalil Virgolini, Irene J. Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT |
| title | Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT |
| title_full | Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT |
| title_fullStr | Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT |
| title_full_unstemmed | Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT |
| title_short | Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT |
| title_sort | localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (pcc/pgl) using 18f-fdg pet/ct |
| url | http://psasir.upm.edu.my/id/eprint/34396/ http://psasir.upm.edu.my/id/eprint/34396/ http://psasir.upm.edu.my/id/eprint/34396/ http://psasir.upm.edu.my/id/eprint/34396/1/Localization%20and%20prediction%20of%20malignant%20potential%20in%20recurrent.pdf |