In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice
Fermented red yeast rice has been traditionally consumed as medication in Asian cuisine. This study aimed to determine the in vivo hypocholesterolemic and antioxidant effects of fermented red yeast rice water extract produced using Malaysian Agricultural Research and Development Institute (MARDI) Mo...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/34156/ http://psasir.upm.edu.my/id/eprint/34156/1/In%20vivo%20hypocholesterolemic%20effect%20of%20MARDI%20fermented%20red%20yeast%20rice%20water%20extract%20in%20high%20cholesterol%20diet%20fed%20mice.pdf |
| _version_ | 1848847691197448192 |
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| author | Yeap, Swee Keong Beh, Boon Kee Kong, Joan Ho, Wan Yong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Hussin, Aminuddin Jaganath, Indu Bala Mohamed Alitheen, Noorjahan Banu Jamaluddin, Anisah Long, Kamariah |
| author_facet | Yeap, Swee Keong Beh, Boon Kee Kong, Joan Ho, Wan Yong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Hussin, Aminuddin Jaganath, Indu Bala Mohamed Alitheen, Noorjahan Banu Jamaluddin, Anisah Long, Kamariah |
| author_sort | Yeap, Swee Keong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Fermented red yeast rice has been traditionally consumed as medication in Asian cuisine. This study aimed to determine the in vivo hypocholesterolemic and antioxidant effects of fermented red yeast rice water extract produced using Malaysian Agricultural Research and Development Institute (MARDI) Monascus purpureus strains in mice fed with high cholesterol diet. Absence of monacolin-k, lower level of γ-aminobutyric acid (GABA), higher content of total amino acids, and antioxidant activities were detected in MARDI fermented red yeast rice water extract (MFRYR). In vivo MFRYR treatment on hypercholesterolemic mice recorded similar lipid lowering effect as commercial red yeast rice extract (CRYR) as it helps to reduce the elevated serum liver enzyme and increased the antioxidant levels in liver. This effect was also associated with the upregulation of apolipoproteins-E and inhibition of Von Willebrand factor expression. In summary, MFRYR enriched in antioxidant and amino acid without monacolin-k showed similar hypocholesterolemic effect as CRYR that was rich in monacolin-k and GABA. |
| first_indexed | 2025-11-15T09:22:37Z |
| format | Article |
| id | upm-34156 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:22:37Z |
| publishDate | 2014 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-341562015-12-07T07:24:02Z http://psasir.upm.edu.my/id/eprint/34156/ In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice Yeap, Swee Keong Beh, Boon Kee Kong, Joan Ho, Wan Yong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Hussin, Aminuddin Jaganath, Indu Bala Mohamed Alitheen, Noorjahan Banu Jamaluddin, Anisah Long, Kamariah Fermented red yeast rice has been traditionally consumed as medication in Asian cuisine. This study aimed to determine the in vivo hypocholesterolemic and antioxidant effects of fermented red yeast rice water extract produced using Malaysian Agricultural Research and Development Institute (MARDI) Monascus purpureus strains in mice fed with high cholesterol diet. Absence of monacolin-k, lower level of γ-aminobutyric acid (GABA), higher content of total amino acids, and antioxidant activities were detected in MARDI fermented red yeast rice water extract (MFRYR). In vivo MFRYR treatment on hypercholesterolemic mice recorded similar lipid lowering effect as commercial red yeast rice extract (CRYR) as it helps to reduce the elevated serum liver enzyme and increased the antioxidant levels in liver. This effect was also associated with the upregulation of apolipoproteins-E and inhibition of Von Willebrand factor expression. In summary, MFRYR enriched in antioxidant and amino acid without monacolin-k showed similar hypocholesterolemic effect as CRYR that was rich in monacolin-k and GABA. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/34156/1/In%20vivo%20hypocholesterolemic%20effect%20of%20MARDI%20fermented%20red%20yeast%20rice%20water%20extract%20in%20high%20cholesterol%20diet%20fed%20mice.pdf Yeap, Swee Keong and Beh, Boon Kee and Kong, Joan and Ho, Wan Yong and Mohd Yusof, Hamidah and Mohamad, Nurul Elyani and Hussin, Aminuddin and Jaganath, Indu Bala and Mohamed Alitheen, Noorjahan Banu and Jamaluddin, Anisah and Long, Kamariah (2014) In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice. Evidence-Based Complementary and Alternative Medicine, 2014 (707829). pp. 1-7. ISSN 1741-427X; ESSN: 1741-4288 http://www.hindawi.com/journals/ecam/2014/707829/abs/ 10.1155/2014/707829 |
| spellingShingle | Yeap, Swee Keong Beh, Boon Kee Kong, Joan Ho, Wan Yong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Hussin, Aminuddin Jaganath, Indu Bala Mohamed Alitheen, Noorjahan Banu Jamaluddin, Anisah Long, Kamariah In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice |
| title | In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice |
| title_full | In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice |
| title_fullStr | In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice |
| title_full_unstemmed | In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice |
| title_short | In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice |
| title_sort | in vivo hypocholesterolemic effect of mardi fermented red yeast rice water extract in high cholesterol diet fed mice |
| url | http://psasir.upm.edu.my/id/eprint/34156/ http://psasir.upm.edu.my/id/eprint/34156/ http://psasir.upm.edu.my/id/eprint/34156/ http://psasir.upm.edu.my/id/eprint/34156/1/In%20vivo%20hypocholesterolemic%20effect%20of%20MARDI%20fermented%20red%20yeast%20rice%20water%20extract%20in%20high%20cholesterol%20diet%20fed%20mice.pdf |