Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding regio...
| Main Authors: | , , , , , |
|---|---|
| Format: | Patent |
| Published: |
2014
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/33963/ |
| _version_ | 1848847641844121600 |
|---|---|
| author | Tan, Wen Siang Ho, Kok Lian Yong, Chean Yeah Goh, Zee Hong Omar, Abdul Rahman Yeap, Swee Keong |
| author_facet | Tan, Wen Siang Ho, Kok Lian Yong, Chean Yeah Goh, Zee Hong Omar, Abdul Rahman Yeap, Swee Keong |
| author_sort | Tan, Wen Siang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding region. The present invention further provides spherical epitope-displaying virus-like particles (VLPs) comprising the MrNV capsid protein and one or more immunogenic components, such as ‘a’ determinant of HBV and M2e of influenza virus. The particles may contain one or more copies of each epitope. The invention further provides a method of producing such VLPs, and uses of such VLPs. |
| first_indexed | 2025-11-15T09:21:50Z |
| format | Patent |
| id | upm-33963 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:21:50Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-339632015-04-24T13:38:54Z http://psasir.upm.edu.my/id/eprint/33963/ Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components Tan, Wen Siang Ho, Kok Lian Yong, Chean Yeah Goh, Zee Hong Omar, Abdul Rahman Yeap, Swee Keong The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding region. The present invention further provides spherical epitope-displaying virus-like particles (VLPs) comprising the MrNV capsid protein and one or more immunogenic components, such as ‘a’ determinant of HBV and M2e of influenza virus. The particles may contain one or more copies of each epitope. The invention further provides a method of producing such VLPs, and uses of such VLPs. 2014-09-09 Patent NonPeerReviewed Tan Wen Siang (2014) Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components. PI2014702540. |
| spellingShingle | Tan, Wen Siang Ho, Kok Lian Yong, Chean Yeah Goh, Zee Hong Omar, Abdul Rahman Yeap, Swee Keong Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components |
| title | Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components |
| title_full | Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components |
| title_fullStr | Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components |
| title_full_unstemmed | Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components |
| title_short | Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components |
| title_sort | virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components |
| url | http://psasir.upm.edu.my/id/eprint/33963/ |