Phenol conjugation in the desert hopping mouse, notomys alexis
1. The ratio of phenyl sulphate to phenyl glucuronide formed in vitro follows that seen in whole animals. 2. Phenyl sulphate formation from phenol, ATP and sulphate is subject to inhibition by phenol at high concentrations. 3. Addition of exogenous PAPS stimulates phenyl sulphate formation. It is...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
1978
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| Online Access: | http://psasir.upm.edu.my/id/eprint/33892/ http://psasir.upm.edu.my/id/eprint/33892/1/33892%20phenol%20conjugation.pdf |
| _version_ | 1848847624548909056 |
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| author | Ramli , Johari Wheldrake , J. F. |
| author_facet | Ramli , Johari Wheldrake , J. F. |
| author_sort | Ramli , Johari |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | 1. The ratio of phenyl sulphate to phenyl glucuronide formed in vitro follows that seen in whole animals.
2. Phenyl sulphate formation from phenol, ATP and sulphate is subject to inhibition by phenol at high concentrations.
3. Addition of exogenous PAPS stimulates phenyl sulphate formation. It is concluded that availability of PAPS limits the rate of phenyl sulphate formation.
4. The preferential formation of phenyl sulphate at low phenol concentrations is explicable by the observation that the sulphotransferase has a higher affinity for phenol than does the UDP-glucuronyl-transferase. |
| first_indexed | 2025-11-15T09:21:34Z |
| format | Article |
| id | upm-33892 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:21:34Z |
| publishDate | 1978 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-338922015-04-14T03:48:56Z http://psasir.upm.edu.my/id/eprint/33892/ Phenol conjugation in the desert hopping mouse, notomys alexis Ramli , Johari Wheldrake , J. F. 1. The ratio of phenyl sulphate to phenyl glucuronide formed in vitro follows that seen in whole animals. 2. Phenyl sulphate formation from phenol, ATP and sulphate is subject to inhibition by phenol at high concentrations. 3. Addition of exogenous PAPS stimulates phenyl sulphate formation. It is concluded that availability of PAPS limits the rate of phenyl sulphate formation. 4. The preferential formation of phenyl sulphate at low phenol concentrations is explicable by the observation that the sulphotransferase has a higher affinity for phenol than does the UDP-glucuronyl-transferase. Elsevier 1978 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/33892/1/33892%20phenol%20conjugation.pdf Ramli , Johari and Wheldrake , J. F. (1978) Phenol conjugation in the desert hopping mouse, notomys alexis. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 69 (2). pp. 379-381. ISSN 0306-4492 10.1016/0306-4492(81)90154-4 |
| spellingShingle | Ramli , Johari Wheldrake , J. F. Phenol conjugation in the desert hopping mouse, notomys alexis |
| title | Phenol conjugation in the desert hopping mouse, notomys alexis |
| title_full | Phenol conjugation in the desert hopping mouse, notomys alexis |
| title_fullStr | Phenol conjugation in the desert hopping mouse, notomys alexis |
| title_full_unstemmed | Phenol conjugation in the desert hopping mouse, notomys alexis |
| title_short | Phenol conjugation in the desert hopping mouse, notomys alexis |
| title_sort | phenol conjugation in the desert hopping mouse, notomys alexis |
| url | http://psasir.upm.edu.my/id/eprint/33892/ http://psasir.upm.edu.my/id/eprint/33892/ http://psasir.upm.edu.my/id/eprint/33892/1/33892%20phenol%20conjugation.pdf |