Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit
‘Sibu olive’ is known botanically as "Canarium Odontophyllum Miq." The present study was designed to assess the effect of Sibu olive (SO) consumption on cholesterol level and the development of atherosclerosis of mild hypercholesterolemia rabbits. A total of thirty five rabbits were r...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Published: |
Springer Berlin Heidelberg (Springer Link)
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/33769/ |
| _version_ | 1848847590333874176 |
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| author | M.H., Nurulhuda Azlan, Azrina Ismail, Amin Amom, Zulkhairi Shakirin, Faridah Hanim |
| author_facet | M.H., Nurulhuda Azlan, Azrina Ismail, Amin Amom, Zulkhairi Shakirin, Faridah Hanim |
| author_sort | M.H., Nurulhuda |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | ‘Sibu olive’ is known botanically as "Canarium
Odontophyllum Miq." The present study was designed to assess
the effect of Sibu olive (SO) consumption on cholesterol
level and the development of atherosclerosis of mild
hypercholesterolemia rabbits. A total of thirty five rabbits
were randomly divided into 5 groups (n=7); NC (normal diet),
PC (normal diet + 0.5% cholesterol), HS (hypercholestrolemic
diet + 10 mg/kg/day simvastatin), HF (hypercholsterolemic diet
+ 5% fullfat SO) and HD group (hypercholesterolemic diet +
5% defatted SO). Main outcome measures were body weight
changes, changes in total cholesterol, low-density lipoprotein
cholesterol ( LDL-C), high-density lipoprotein cholesterol
(HDL-C), and atherosclerotic plaque formation. After 8 weeks,
there was increment in body weight changes (1.75–2.24 kg) of
animals. The HD group showed significant reduction in total
cholesterol (96.3%), LDL-C (26.5%) and HDL-C increment
(46.8%) relative to PC. Futhermore, the atherosclerotic plaque
formation in HD group diminished by 79.4% compared to PC.
The polyphenols like phenolic acids, flavonoids, and
anthocyanidins) that promote the lipid lowering potential of
the SO fruit. Hence, in the future, SO fruit may serve as potent
alternative treatment in the prevention of atherosclerosis. |
| first_indexed | 2025-11-15T09:21:01Z |
| format | Conference or Workshop Item |
| id | upm-33769 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:21:01Z |
| publishDate | 2012 |
| publisher | Springer Berlin Heidelberg (Springer Link) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-337692015-03-27T07:00:27Z http://psasir.upm.edu.my/id/eprint/33769/ Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit M.H., Nurulhuda Azlan, Azrina Ismail, Amin Amom, Zulkhairi Shakirin, Faridah Hanim ‘Sibu olive’ is known botanically as "Canarium Odontophyllum Miq." The present study was designed to assess the effect of Sibu olive (SO) consumption on cholesterol level and the development of atherosclerosis of mild hypercholesterolemia rabbits. A total of thirty five rabbits were randomly divided into 5 groups (n=7); NC (normal diet), PC (normal diet + 0.5% cholesterol), HS (hypercholestrolemic diet + 10 mg/kg/day simvastatin), HF (hypercholsterolemic diet + 5% fullfat SO) and HD group (hypercholesterolemic diet + 5% defatted SO). Main outcome measures were body weight changes, changes in total cholesterol, low-density lipoprotein cholesterol ( LDL-C), high-density lipoprotein cholesterol (HDL-C), and atherosclerotic plaque formation. After 8 weeks, there was increment in body weight changes (1.75–2.24 kg) of animals. The HD group showed significant reduction in total cholesterol (96.3%), LDL-C (26.5%) and HDL-C increment (46.8%) relative to PC. Futhermore, the atherosclerotic plaque formation in HD group diminished by 79.4% compared to PC. The polyphenols like phenolic acids, flavonoids, and anthocyanidins) that promote the lipid lowering potential of the SO fruit. Hence, in the future, SO fruit may serve as potent alternative treatment in the prevention of atherosclerosis. Springer Berlin Heidelberg (Springer Link) 2012 Conference or Workshop Item PeerReviewed M.H., Nurulhuda and Azlan, Azrina and Ismail, Amin and Amom, Zulkhairi and Shakirin, Faridah Hanim (2012) Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit. In: 4th International Conference on Biomedical Engineering, 8-12 Jan 2012, Ho Chi Minh, Vietnam. (pp. 141-144). 10.1007/978-3-642-32183-2_37 |
| spellingShingle | M.H., Nurulhuda Azlan, Azrina Ismail, Amin Amom, Zulkhairi Shakirin, Faridah Hanim Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit |
| title | Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit |
| title_full | Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit |
| title_fullStr | Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit |
| title_full_unstemmed | Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit |
| title_short | Sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit |
| title_sort | sibu olive inhibits artherosclerosis by cholesterol lowering effect in cholesterol fed-rabbit |
| url | http://psasir.upm.edu.my/id/eprint/33769/ http://psasir.upm.edu.my/id/eprint/33769/ |