Activin A: its role and involvement in inflammatory diseases
Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types. Biologically active activins consist of homodimers or heterodimers of two beta (β)...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/32562/ http://psasir.upm.edu.my/id/eprint/32562/1/01%20JST-0473-2013%20Review%20Article%20Rev.pdf |
| _version_ | 1848847238044844032 |
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| author | Tie, Tung Hing Basir, Rusliza Chuah, Yaw Kuang Talib, Herni Nordin, Norshariza |
| author2 | Saad, Mohd Zamri |
| author_facet | Saad, Mohd Zamri Tie, Tung Hing Basir, Rusliza Chuah, Yaw Kuang Talib, Herni Nordin, Norshariza |
| author_sort | Tie, Tung Hing |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types. Biologically active activins consist of homodimers or heterodimers of two beta (β) subunits that are linked together by a single covalent disulphide bond. The subunits in humans are βA, βB, βC and βE. As an example, a combination of two βA subunits will produce a unit of activin A. These proteins are found in most cells of body such as macrophage and activated circulating monocytes. Their role in inflammation can be categorised into two types, either pro- or anti-inflammatory agents, depending on the cell type and phase. Activin signals are kept in balance by antagonist follistatin (Fst), which is a glycoprotein expressed in tissues and encoded by the follistatin gene in humans. |
| first_indexed | 2025-11-15T09:15:25Z |
| format | Article |
| id | upm-32562 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:15:25Z |
| publishDate | 2015 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-325622016-01-26T04:32:30Z http://psasir.upm.edu.my/id/eprint/32562/ Activin A: its role and involvement in inflammatory diseases Tie, Tung Hing Basir, Rusliza Chuah, Yaw Kuang Talib, Herni Nordin, Norshariza Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types. Biologically active activins consist of homodimers or heterodimers of two beta (β) subunits that are linked together by a single covalent disulphide bond. The subunits in humans are βA, βB, βC and βE. As an example, a combination of two βA subunits will produce a unit of activin A. These proteins are found in most cells of body such as macrophage and activated circulating monocytes. Their role in inflammation can be categorised into two types, either pro- or anti-inflammatory agents, depending on the cell type and phase. Activin signals are kept in balance by antagonist follistatin (Fst), which is a glycoprotein expressed in tissues and encoded by the follistatin gene in humans. Universiti Putra Malaysia Press Saad, Mohd Zamri 2015-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/32562/1/01%20JST-0473-2013%20Review%20Article%20Rev.pdf Tie, Tung Hing and Basir, Rusliza and Chuah, Yaw Kuang and Talib, Herni and Nordin, Norshariza (2015) Activin A: its role and involvement in inflammatory diseases. Pertanika Journal of Science & Technology, 23 (2). pp. 163-176. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2023%20%282%29%20Jul.%202015/01%20JST-0473-2013%20Review%20Article%20Rev.pdf |
| spellingShingle | Tie, Tung Hing Basir, Rusliza Chuah, Yaw Kuang Talib, Herni Nordin, Norshariza Activin A: its role and involvement in inflammatory diseases |
| title | Activin A: its role and involvement in inflammatory diseases |
| title_full | Activin A: its role and involvement in inflammatory diseases |
| title_fullStr | Activin A: its role and involvement in inflammatory diseases |
| title_full_unstemmed | Activin A: its role and involvement in inflammatory diseases |
| title_short | Activin A: its role and involvement in inflammatory diseases |
| title_sort | activin a: its role and involvement in inflammatory diseases |
| url | http://psasir.upm.edu.my/id/eprint/32562/ http://psasir.upm.edu.my/id/eprint/32562/ http://psasir.upm.edu.my/id/eprint/32562/1/01%20JST-0473-2013%20Review%20Article%20Rev.pdf |