GLP-1 promoter mediated insulin expression for the treatment of diabetes.
Insulin gene therapy is one of many envisioned alternative treatments of diabetes. Diabetes gene therapy would be possible if insulin could be produced in a regulated and specifically in a sensitive manner dependent on the blood glucose level.Therefore, the present invention relates to a method for...
| Main Authors: | , , |
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| Format: | Patent |
| Language: | English |
| Published: |
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/32198/ http://psasir.upm.edu.my/id/eprint/32198/1/US20140112895A1.pdf |
| _version_ | 1848847150247575552 |
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| author | Ahmad, Zalinah Omar, Abdul Rahman Rasouli, Mina |
| author_facet | Ahmad, Zalinah Omar, Abdul Rahman Rasouli, Mina |
| author_sort | Ahmad, Zalinah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Insulin gene therapy is one of many envisioned alternative treatments of diabetes. Diabetes gene therapy would be possible if insulin could be produced in a regulated and specifically in a sensitive manner dependent on the blood glucose level.Therefore, the present invention relates to a method for the isolation of GLP-1 expressing cells, to nucleic acids sequence construction or vectors useful for isolating GLP-1 expressing cell and to the GLP-1 expressing cells isolated therewith. Furthermore, the inventions relates to a method of nucleic acids sequence construction or vectors under the control of the GLP-1 promoter expressing insulin in a recombinant GLP-1 expressing cell line. The cells of the present invention are particular useful for the treatment of diabetes and may be used in a gene therapy approach to treat diabetes and other disorders related to the nutrient metabloism. |
| first_indexed | 2025-11-15T09:14:02Z |
| format | Patent |
| id | upm-32198 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:14:02Z |
| publishDate | 2010 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-321982024-10-01T01:55:51Z http://psasir.upm.edu.my/id/eprint/32198/ GLP-1 promoter mediated insulin expression for the treatment of diabetes. Ahmad, Zalinah Omar, Abdul Rahman Rasouli, Mina Insulin gene therapy is one of many envisioned alternative treatments of diabetes. Diabetes gene therapy would be possible if insulin could be produced in a regulated and specifically in a sensitive manner dependent on the blood glucose level.Therefore, the present invention relates to a method for the isolation of GLP-1 expressing cells, to nucleic acids sequence construction or vectors useful for isolating GLP-1 expressing cell and to the GLP-1 expressing cells isolated therewith. Furthermore, the inventions relates to a method of nucleic acids sequence construction or vectors under the control of the GLP-1 promoter expressing insulin in a recombinant GLP-1 expressing cell line. The cells of the present invention are particular useful for the treatment of diabetes and may be used in a gene therapy approach to treat diabetes and other disorders related to the nutrient metabloism. 2010-10-08 Patent NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/32198/1/US20140112895A1.pdf Zalinah Ahmad (2010) GLP-1 promoter mediated insulin expression for the treatment of diabetes. UNSPECIFIED. https://patents.google.com/patent/US20140112895A1/en |
| spellingShingle | Ahmad, Zalinah Omar, Abdul Rahman Rasouli, Mina GLP-1 promoter mediated insulin expression for the treatment of diabetes. |
| title | GLP-1 promoter mediated insulin expression for the treatment of diabetes. |
| title_full | GLP-1 promoter mediated insulin expression for the treatment of diabetes. |
| title_fullStr | GLP-1 promoter mediated insulin expression for the treatment of diabetes. |
| title_full_unstemmed | GLP-1 promoter mediated insulin expression for the treatment of diabetes. |
| title_short | GLP-1 promoter mediated insulin expression for the treatment of diabetes. |
| title_sort | glp-1 promoter mediated insulin expression for the treatment of diabetes. |
| url | http://psasir.upm.edu.my/id/eprint/32198/ http://psasir.upm.edu.my/id/eprint/32198/ http://psasir.upm.edu.my/id/eprint/32198/1/US20140112895A1.pdf |