Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products
In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Multidisciplinary Digital Publishing Institute
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30812/ http://psasir.upm.edu.my/id/eprint/30812/1/Efficient%20synthesis%20of%202.pdf |
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| author | Gull, Yasmeen Rasool, Nasir Noreen, Mnaza Nasim, Faiz-ul-Hassan Yaqoob, Asma Kousar, Shazia Rashid, Umer Bukhari, Iftikhar Hussain Zubair, Muhammad Islam, Md. Saiful |
| author_facet | Gull, Yasmeen Rasool, Nasir Noreen, Mnaza Nasim, Faiz-ul-Hassan Yaqoob, Asma Kousar, Shazia Rashid, Umer Bukhari, Iftikhar Hussain Zubair, Muhammad Islam, Md. Saiful |
| author_sort | Gull, Yasmeen |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL. |
| first_indexed | 2025-11-15T09:08:13Z |
| format | Article |
| id | upm-30812 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:08:13Z |
| publishDate | 2013 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-308122015-10-20T07:39:19Z http://psasir.upm.edu.my/id/eprint/30812/ Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products Gull, Yasmeen Rasool, Nasir Noreen, Mnaza Nasim, Faiz-ul-Hassan Yaqoob, Asma Kousar, Shazia Rashid, Umer Bukhari, Iftikhar Hussain Zubair, Muhammad Islam, Md. Saiful In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL. Multidisciplinary Digital Publishing Institute 2013-07-25 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30812/1/Efficient%20synthesis%20of%202.pdf Gull, Yasmeen and Rasool, Nasir and Noreen, Mnaza and Nasim, Faiz-ul-Hassan and Yaqoob, Asma and Kousar, Shazia and Rashid, Umer and Bukhari, Iftikhar Hussain and Zubair, Muhammad and Islam, Md. Saiful (2013) Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products. Molecules, 18 (8). pp. 8845-8857. ISSN 1420-3049 http://www.mdpi.com/1420-3049/18/8 10.3390/molecules18088845 English |
| spellingShingle | Gull, Yasmeen Rasool, Nasir Noreen, Mnaza Nasim, Faiz-ul-Hassan Yaqoob, Asma Kousar, Shazia Rashid, Umer Bukhari, Iftikhar Hussain Zubair, Muhammad Islam, Md. Saiful Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
| title | Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
| title_full | Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
| title_fullStr | Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
| title_full_unstemmed | Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
| title_short | Efficient synthesis of 2-amino-6-arylbenzothiazoles via Pd(0) Suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
| title_sort | efficient synthesis of 2-amino-6-arylbenzothiazoles via pd(0) suzuki cross coupling reactions : potent urease enzyme inhibition and nitric oxide scavenging activities of the products |
| url | http://psasir.upm.edu.my/id/eprint/30812/ http://psasir.upm.edu.my/id/eprint/30812/ http://psasir.upm.edu.my/id/eprint/30812/ http://psasir.upm.edu.my/id/eprint/30812/1/Efficient%20synthesis%20of%202.pdf |