Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells
Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a “natural cancer fighter”, being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In par...
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| Format: | Article |
| Language: | English |
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MDPI
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30728/ http://psasir.upm.edu.my/id/eprint/30728/1/Pro-apoptotic%20effect%20of%20rice%20bran%20inositol%20hexaphosphate%20%28IP6%29%20on%20HT-29%20colorectal%20cancer%20cells.pdf |
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| author | Shafie, Nurul Husna Mohd Esa, Norhaizan Ithnin, Hairuszah Saad, Norazalina Pandurangan, Ashok Kumar |
| author_facet | Shafie, Nurul Husna Mohd Esa, Norhaizan Ithnin, Hairuszah Saad, Norazalina Pandurangan, Ashok Kumar |
| author_sort | Shafie, Nurul Husna |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a “natural cancer fighter”, being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In particular, our data provided strong evidence for the induction of apoptotic cell death, which may be attributable to the up-regulation of Bax and down-regulation of Bcl-xl in favor of apoptosis. In addition, the up-regulation of caspase-3 and -8 expression and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells when exposed to IP6. Collectively, this present study has shown that rice bran IP6 induces apoptosis, by regulating the pro- and anti-apoptotic markers; Bax and Bcl-xl and via the activation of caspase molecules (caspase-3 and -8) |
| first_indexed | 2025-11-15T09:07:50Z |
| format | Article |
| id | upm-30728 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:07:50Z |
| publishDate | 2013 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-307282016-02-05T02:21:41Z http://psasir.upm.edu.my/id/eprint/30728/ Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells Shafie, Nurul Husna Mohd Esa, Norhaizan Ithnin, Hairuszah Saad, Norazalina Pandurangan, Ashok Kumar Inositol hexaphosphate (IP6), or phytic acid is a natural dietary ingredient and has been described as a “natural cancer fighter”, being an essential component of nutritional diets. The marked anti-cancer effect of IP6 has resulted in our quest for an understanding of its mechanism of action. In particular, our data provided strong evidence for the induction of apoptotic cell death, which may be attributable to the up-regulation of Bax and down-regulation of Bcl-xl in favor of apoptosis. In addition, the up-regulation of caspase-3 and -8 expression and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells when exposed to IP6. Collectively, this present study has shown that rice bran IP6 induces apoptosis, by regulating the pro- and anti-apoptotic markers; Bax and Bcl-xl and via the activation of caspase molecules (caspase-3 and -8) MDPI 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30728/1/Pro-apoptotic%20effect%20of%20rice%20bran%20inositol%20hexaphosphate%20%28IP6%29%20on%20HT-29%20colorectal%20cancer%20cells.pdf Shafie, Nurul Husna and Mohd Esa, Norhaizan and Ithnin, Hairuszah and Saad, Norazalina and Pandurangan, Ashok Kumar (2013) Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells. International Journal of Molecular Sciences, 14 (12). pp. 23545-23558. ISSN 1422-0067; ESSN:1422-0067 http://www.mdpi.com/1422-0067/14/12/23545 10.3390/ijms141223545 |
| spellingShingle | Shafie, Nurul Husna Mohd Esa, Norhaizan Ithnin, Hairuszah Saad, Norazalina Pandurangan, Ashok Kumar Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells |
| title | Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells |
| title_full | Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells |
| title_fullStr | Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells |
| title_full_unstemmed | Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells |
| title_short | Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells |
| title_sort | pro-apoptotic effect of rice bran inositol hexaphosphate (ip6) on ht-29 colorectal cancer cells |
| url | http://psasir.upm.edu.my/id/eprint/30728/ http://psasir.upm.edu.my/id/eprint/30728/ http://psasir.upm.edu.my/id/eprint/30728/ http://psasir.upm.edu.my/id/eprint/30728/1/Pro-apoptotic%20effect%20of%20rice%20bran%20inositol%20hexaphosphate%20%28IP6%29%20on%20HT-29%20colorectal%20cancer%20cells.pdf |