Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways

QR Code

Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways

Nutritional or dietary factors have drawn attention due to their potential as an effective chemopreventive agent, which is considered a more rational strategy in cancer treatment. This study was designed to evaluate the effect of IP₆ extracted from rice bran on azoxymethane- (AOM-) induced colorecta...

Full description

Bibliographic Details
Main Authors:	Shafie, Nurul Husna, Mohd Esa, Norhaizan, Ithnin, Hairuszah, Md. Akim, Abdah, Saad, Norazalina, Pandurangan, Ashok Kumar
Format:	Article
Language:	English
Published:	Hindawi Publishing Corporation 2013
Online Access:	http://psasir.upm.edu.my/id/eprint/30727/ http://psasir.upm.edu.my/id/eprint/30727/1/Preventive%20inositol%20hexaphosphate%20extracted%20from%20rice%20bran%20inhibits%20colorectal%20cancer%20through%20involvement%20of%20Wnt.pdf

Similar Items

Pro-apoptotic effect of rice bran inositol hexaphosphate (IP6) on HT-29 colorectal cancer cells
by: Shafie, Nurul Husna, et al.
Published: (2013)

Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA)
by: Saad, Norazalina, et al.
Published: (2013)

Rice bran phytic acid (IP6) induces growth inhibition, cell cycle arrest and apoptosis on human colorectal adenocarcinoma cells
by: Mohd Esa, Norhaizan, et al.
Published: (2010)

Germinated brown rice (GBR) reduces the incidence of aberrant crypt foci with the involvement of β-catenin and COX-2 in azoxymethane-induced colon cancer in rats.
by: Saiful Yazan, Latifah, et al.
Published: (2010)

Optimization of optimum condition for phytic acid extraction from rice bran
by: Saad, Norazalina, et al.
Published: (2011)

Expression of β-catenin, Ki67 and stroma percentage in colorectal cancer
by: Suanno, Cristina
Published: (2021)

The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs)
by: Rogers, H.A., et al.
Published: (2013)

Anticarcinogenic afficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats
by: Saad, Norazalina, et al.
Published: (2010)

The Philippines stingless bee propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway
by: Tang, Yulan, et al.
Published: (2022)

Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells
by: Pandurangan, Ashok Kumar, et al.
Published: (2018)

Molecular targets of colorectal cancer: an insight on intracellular cellular signaling pathways
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Dietary non-nutritive factors on molecular targets of colorectal cancer: an update
by: Pandurangan, Ashok Kumar, et al.
Published: (2013)

Expression Profile of Wnt/β-Catenin Signalling Molecules and the Wnt Antagonist Secreted Frizzled-Related Protein 4 in Apoptosis in Breast Cancer Tissue Micro-Arrays
by: Berry, A., et al.
Published: (2014)

The role of Wnt/β-catenin signalling in the regulation of liver progenitor cell responses in non-alcoholic fatty liver disease
by: Shirolkar, Gayatri Dhananjay
Published: (2021)

Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Water extract of brewers' rice induces apoptosis in human colorectal cancer cells via activation of caspase-3 and caspase-8 and downregulates the Wnt/β-catenin downstream signaling pathway in brewers' rice-treated rats with azoxymethane-induced colon carcinogenesis
by: Tan, Bee Ling, et al.
Published: (2015)

WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma
by: Rogers, H.A., et al.
Published: (2012)

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
by: Coombs, G., et al.
Published: (2012)

Could we address the interplay between CD133, Wnt/β-Catenin, and TERT signaling pathways as a potential target for Glioblastoma therapy?
by: Behrooz, Amir Barzegar, et al.
Published: (2021)

GSK-3β phosphorylation and alteration of β-catenin in hepatocellular carcinoma
by: Ban, Ke Chen, et al.
Published: (2003)

Wnt/ß-Catenin Signalling during Liver Metabolism, Chronic Liver Disease and Hepatocarcinogenesis
by: Shirolkar, Gayatri, et al.
Published: (2018)

Extracellular matrix (ECM) activates β-catenin signaling in uterine fibroids
by: Ko, Y., et al.
Published: (2018)

Antioxidant and Cytotoxicity effect of rice Bran Phytic Acid as an anticancer agent on ovarian, breast and liver cancer cell lines.
by: Mohd Esa , Norhaizan, et al.
Published: (2011)

SFRP-4 abrogates Wnt-3a-induced ß-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation
by: Constantinou, T., et al.
Published: (2008)

Breast cancer stem-like cells are inhibited by diosgenin, a steroidal saponin, by the attenuation of the Wnt ß-catenin signaling via the Wnt antagonist secreted frizzled related protein-4
by: Bhuvanalakshmi, G., et al.
Published: (2017)

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells
by: Schwab, R., et al.
Published: (2017)

Overexpression of WNT2 and TSG101 genes in colorectal carcinoma
by: Ma, Xiang Ru, et al.
Published: (2008)

Relationship between tumour-associated macrophages, CD8+ and IL17+ Cells, TGF-β, TGF-βRII, IL-17R and WNT signaling in colorectal carcinoma
by: Chai, Boon Yean
Published: (2018)

Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-ß-catenin-mediated intestinal tumor growth and regeneration
by: Phesse, T., et al.
Published: (2014)

Elucidation of the WNT & AKT/Phosphoinositide-3-Kinase Pathways in Colorectal Carcinoma
by: Khor, Tin Oo
Published: (2004)

Disruption of β-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair
by: Moheimani, F., et al.
Published: (2015)

Paracrine communication modulates production of Wnt antagonists and COX1-mediated prostaglandins in a decidual-trophoblast co-culture model
by: Nayeem, S., et al.
Published: (2015)

Coordination studies of inositols with aluminium and related cations
by: Chokazinga, Davlin
Published: (2003)

Rice bran: from waste to nutritious food ingredients
by: Tan, Bee Ling, et al.
Published: (2023)

Relationships between Wnt-Notch-Hippo signaling pathways and their relevance to colorectal cancer pathogenesis
by: Chai, Boon Lee
Published: (2018)

COX-2 inhibitors: a potential target for drug therapy in the management of colorectal cancer
by: Ryan, A R, et al.
Published: (1999)

Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer
by: Fifis, T., et al.
Published: (2014)

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression
by: Vincan, Elizabeth, et al.
Published: (2008)

Analysis of Wnt/FZD-mediated signalling in a cell line model of colorectal cancer morphogenesis
by: Vincan, Elizabeth, et al.
Published: (2008)