Parametric maximum likelihood estimation of cure fraction using interval-censored data
A significant proportion of patients in cancer clinical trials can be cured. That is, the symptoms of the disease disappear completely and the disease never recurs. In this article, the focus is on estimation of the proportion of patients who are cured. The parametric maximum likelihood estimati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Columbia International Publishing
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30398/ http://psasir.upm.edu.my/id/eprint/30398/1/Parametric%20maximum%20likelihood%20estimation%20of%20cure%20fraction%20using%20interval.pdf |
| _version_ | 1848846665210920960 |
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| author | Aljawadi, Bader Ahmad I. Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Al-Omari, Mohamad |
| author_facet | Aljawadi, Bader Ahmad I. Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Al-Omari, Mohamad |
| author_sort | Aljawadi, Bader Ahmad I. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A significant proportion of patients in cancer clinical trials can be cured. That is, the symptoms of the disease
disappear completely and the disease never recurs. In this article, the focus is on estimation of the proportion
of patients who are cured. The parametric maximum likelihood estimation method was used for estimation of
the cure fraction based on application of the bounded cumulative hazard (BCH) model to interval-censored
data. We ran the analysis using the EM algorithm considering two cases: i) when no covariates were involved
in the estimation, and ii) when some covariates were involved. This paper shows derivation of the estimation
equations for the cure rate parameter followed by a simulation study. |
| first_indexed | 2025-11-15T09:06:19Z |
| format | Article |
| id | upm-30398 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:06:19Z |
| publishDate | 2013 |
| publisher | Columbia International Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-303982016-02-15T05:02:46Z http://psasir.upm.edu.my/id/eprint/30398/ Parametric maximum likelihood estimation of cure fraction using interval-censored data Aljawadi, Bader Ahmad I. Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Al-Omari, Mohamad A significant proportion of patients in cancer clinical trials can be cured. That is, the symptoms of the disease disappear completely and the disease never recurs. In this article, the focus is on estimation of the proportion of patients who are cured. The parametric maximum likelihood estimation method was used for estimation of the cure fraction based on application of the bounded cumulative hazard (BCH) model to interval-censored data. We ran the analysis using the EM algorithm considering two cases: i) when no covariates were involved in the estimation, and ii) when some covariates were involved. This paper shows derivation of the estimation equations for the cure rate parameter followed by a simulation study. Columbia International Publishing 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30398/1/Parametric%20maximum%20likelihood%20estimation%20of%20cure%20fraction%20using%20interval.pdf Aljawadi, Bader Ahmad I. and Abu Bakar, Mohd Rizam and Ibrahim, Noor Akma and Al-Omari, Mohamad (2013) Parametric maximum likelihood estimation of cure fraction using interval-censored data. Journal of Advanced Computing, 2 (2). pp. 43-58. ISSN 2165-7823 http://dx.doi.org/10.7726/jac.2013.1004 10.7726/jac.2013.1004 |
| spellingShingle | Aljawadi, Bader Ahmad I. Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Al-Omari, Mohamad Parametric maximum likelihood estimation of cure fraction using interval-censored data |
| title | Parametric maximum likelihood estimation of cure fraction using interval-censored data |
| title_full | Parametric maximum likelihood estimation of cure fraction using interval-censored data |
| title_fullStr | Parametric maximum likelihood estimation of cure fraction using interval-censored data |
| title_full_unstemmed | Parametric maximum likelihood estimation of cure fraction using interval-censored data |
| title_short | Parametric maximum likelihood estimation of cure fraction using interval-censored data |
| title_sort | parametric maximum likelihood estimation of cure fraction using interval-censored data |
| url | http://psasir.upm.edu.my/id/eprint/30398/ http://psasir.upm.edu.my/id/eprint/30398/ http://psasir.upm.edu.my/id/eprint/30398/ http://psasir.upm.edu.my/id/eprint/30398/1/Parametric%20maximum%20likelihood%20estimation%20of%20cure%20fraction%20using%20interval.pdf |