Steroids from Dysoxylum grande (Meliaceae) leaves
Seven new 23-oxo-cholestane derivatives named as grandol A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were isolated from Dysoxylum grande leaves alongside with a new 3,4-secodammar-4(28)-en-3-oic acid derivative (8). The structures of the compounds were elucidated based on the interpretation...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30301/ http://psasir.upm.edu.my/id/eprint/30301/1/Steroids%20from%20Dysoxylum%20grande.pdf |
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| author | Low, Kok Wah Abas, Faridah Cordell, Geoffrey A. Ito, Hideyuki Ismail, Intan Safinar |
| author_facet | Low, Kok Wah Abas, Faridah Cordell, Geoffrey A. Ito, Hideyuki Ismail, Intan Safinar |
| author_sort | Low, Kok Wah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Seven new 23-oxo-cholestane derivatives named as grandol A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were isolated from Dysoxylum grande leaves alongside with a new 3,4-secodammar-4(28)-en-3-oic acid derivative (8). The structures of the compounds were elucidated based on the interpretation of spectroscopic data, and their relative configurations were established by NOESY 2D NMR data. All of the isolates were tested for anti-acetylcholinesterase activity using thin layer chromatography (TLC)-bioautography with fast blue B salt. Only grandol A (1) and B (2) showed positive results, with clear discoloration at a concentration of 12.5 ppm. However, the obtained IC50 values for grandol A and B, when using Ellman’s method, were not significant (>200 μg/ml). |
| first_indexed | 2025-11-15T09:05:54Z |
| format | Article |
| id | upm-30301 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:05:54Z |
| publishDate | 2013 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-303012015-10-01T07:30:43Z http://psasir.upm.edu.my/id/eprint/30301/ Steroids from Dysoxylum grande (Meliaceae) leaves Low, Kok Wah Abas, Faridah Cordell, Geoffrey A. Ito, Hideyuki Ismail, Intan Safinar Seven new 23-oxo-cholestane derivatives named as grandol A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were isolated from Dysoxylum grande leaves alongside with a new 3,4-secodammar-4(28)-en-3-oic acid derivative (8). The structures of the compounds were elucidated based on the interpretation of spectroscopic data, and their relative configurations were established by NOESY 2D NMR data. All of the isolates were tested for anti-acetylcholinesterase activity using thin layer chromatography (TLC)-bioautography with fast blue B salt. Only grandol A (1) and B (2) showed positive results, with clear discoloration at a concentration of 12.5 ppm. However, the obtained IC50 values for grandol A and B, when using Ellman’s method, were not significant (>200 μg/ml). Elsevier 2013-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30301/1/Steroids%20from%20Dysoxylum%20grande.pdf Low, Kok Wah and Abas, Faridah and Cordell, Geoffrey A. and Ito, Hideyuki and Ismail, Intan Safinar (2013) Steroids from Dysoxylum grande (Meliaceae) leaves. Steroids, 78 (2). pp. 210-219. ISSN 0039-128X; ESSN: 1878-5867 10.1016/j.steroids.2012.09.011 English |
| spellingShingle | Low, Kok Wah Abas, Faridah Cordell, Geoffrey A. Ito, Hideyuki Ismail, Intan Safinar Steroids from Dysoxylum grande (Meliaceae) leaves |
| title | Steroids from Dysoxylum grande (Meliaceae) leaves |
| title_full | Steroids from Dysoxylum grande (Meliaceae) leaves |
| title_fullStr | Steroids from Dysoxylum grande (Meliaceae) leaves |
| title_full_unstemmed | Steroids from Dysoxylum grande (Meliaceae) leaves |
| title_short | Steroids from Dysoxylum grande (Meliaceae) leaves |
| title_sort | steroids from dysoxylum grande (meliaceae) leaves |
| url | http://psasir.upm.edu.my/id/eprint/30301/ http://psasir.upm.edu.my/id/eprint/30301/ http://psasir.upm.edu.my/id/eprint/30301/1/Steroids%20from%20Dysoxylum%20grande.pdf |