Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane (TTMSH...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Contemporary Research Center, Australia
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/30288/ http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf |
| _version_ | 1848846634859888640 |
|---|---|
| author | Mohd Nor, Siti Mariam Mohd Fauzi, Nawwar Fathiah Ismail, Intan Safinar |
| author_facet | Mohd Nor, Siti Mariam Mohd Fauzi, Nawwar Fathiah Ismail, Intan Safinar |
| author_sort | Mohd Nor, Siti Mariam |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their
corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four
cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane
(TTMSH) and azobisisobutyronitrile (AIBN) in toluene to obtain 5-hydro-4-imino-3,6-
dimethylpyran-2-one (4a), 4-amino-5-hydro-3,6,6-trimethylpyran-2-one (4b),3,5-dihydro-4-imino-
6-methylpyran-2-one (4c), and 3,5-Dihydro-4-imino-6,6-dimethylpyran-2-one (4d). |
| first_indexed | 2025-11-15T09:05:50Z |
| format | Article |
| id | upm-30288 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:05:50Z |
| publishDate | 2013 |
| publisher | Contemporary Research Center, Australia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-302882015-10-09T00:40:49Z http://psasir.upm.edu.my/id/eprint/30288/ Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach Mohd Nor, Siti Mariam Mohd Fauzi, Nawwar Fathiah Ismail, Intan Safinar Four new4-N-substituted pyran-2-ones (δ-lactones) were successfully synthesised from their corresponding cyanoalcohols via two reaction steps; (i) acylation and (ii) radical cyclisation. Four cyanobromoesters that were produced from acylation were treated with tris(trimethylsilyl)silane (TTMSH) and azobisisobutyronitrile (AIBN) in toluene to obtain 5-hydro-4-imino-3,6- dimethylpyran-2-one (4a), 4-amino-5-hydro-3,6,6-trimethylpyran-2-one (4b),3,5-dihydro-4-imino- 6-methylpyran-2-one (4c), and 3,5-Dihydro-4-imino-6,6-dimethylpyran-2-one (4d). Contemporary Research Center, Australia 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf Mohd Nor, Siti Mariam and Mohd Fauzi, Nawwar Fathiah and Ismail, Intan Safinar (2013) Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach. International Journal of Education and Research, 1 (6). ISSN 2201-6333; ESSN: 2201-6740 http://www.ijern.com/June-2013.php English |
| spellingShingle | Mohd Nor, Siti Mariam Mohd Fauzi, Nawwar Fathiah Ismail, Intan Safinar Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach |
| title | Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach |
| title_full | Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach |
| title_fullStr | Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach |
| title_full_unstemmed | Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach |
| title_short | Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach |
| title_sort | synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach |
| url | http://psasir.upm.edu.my/id/eprint/30288/ http://psasir.upm.edu.my/id/eprint/30288/ http://psasir.upm.edu.my/id/eprint/30288/1/Synthesis%20of%20nitrogen.pdf |