Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction
This work reports the effectiveness of short polar peptides as asymmetric catalysts in Michael reactions to attain good yields of enantio- and diastereoselective isomers. In a comparison, glutamic acid and histidine produced greater ee and yields when they were applied as the second amino acid in sh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Taylor & Francis
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30274/ http://psasir.upm.edu.my/id/eprint/30274/1/Enantioselectivity%20investigation%20of%20short%20polar%20peptides%20with%20different%20positions%20in%20the%20Michael%20reaction.pdf |
| _version_ | 1848846630700187648 |
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| author | Bayat, Saadi Tejo, Bimo Ario Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Abdul Rahman, Mohd Basyaruddin |
| author_facet | Bayat, Saadi Tejo, Bimo Ario Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Abdul Rahman, Mohd Basyaruddin |
| author_sort | Bayat, Saadi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This work reports the effectiveness of short polar peptides as asymmetric catalysts in Michael reactions to attain good yields of enantio- and diastereoselective isomers. In a comparison, glutamic acid and histidine produced greater ee and yields when they were applied as the second amino acid in short trimeric peptides. These short polar peptides were found to be efficient organocatalysts for the asymmetric Michael addition reaction in water. |
| first_indexed | 2025-11-15T09:05:46Z |
| format | Article |
| id | upm-30274 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:05:46Z |
| publishDate | 2013 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-302742015-08-24T07:35:02Z http://psasir.upm.edu.my/id/eprint/30274/ Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction Bayat, Saadi Tejo, Bimo Ario Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Abdul Rahman, Mohd Basyaruddin This work reports the effectiveness of short polar peptides as asymmetric catalysts in Michael reactions to attain good yields of enantio- and diastereoselective isomers. In a comparison, glutamic acid and histidine produced greater ee and yields when they were applied as the second amino acid in short trimeric peptides. These short polar peptides were found to be efficient organocatalysts for the asymmetric Michael addition reaction in water. Taylor & Francis 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30274/1/Enantioselectivity%20investigation%20of%20short%20polar%20peptides%20with%20different%20positions%20in%20the%20Michael%20reaction.pdf Bayat, Saadi and Tejo, Bimo Ario and Abd. Malek, Emilia and Mohd Yahaya, Normi and Salleh, Abu Bakar and Abdul Rahman, Mohd Basyaruddin (2013) Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction. Synthetic Communications, 43 (20). pp. 2725-2732. ISSN 0039-7911; ESSN: 1532-2432 10.1080/00397911.2012.736005 English |
| spellingShingle | Bayat, Saadi Tejo, Bimo Ario Abd. Malek, Emilia Mohd Yahaya, Normi Salleh, Abu Bakar Abdul Rahman, Mohd Basyaruddin Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction |
| title | Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction |
| title_full | Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction |
| title_fullStr | Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction |
| title_full_unstemmed | Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction |
| title_short | Enantioselectivity investigation of short polar peptides with different positions in the Michael reaction |
| title_sort | enantioselectivity investigation of short polar peptides with different positions in the michael reaction |
| url | http://psasir.upm.edu.my/id/eprint/30274/ http://psasir.upm.edu.my/id/eprint/30274/ http://psasir.upm.edu.my/id/eprint/30274/1/Enantioselectivity%20investigation%20of%20short%20polar%20peptides%20with%20different%20positions%20in%20the%20Michael%20reaction.pdf |