Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus
Phytochemical studies on different parts of Murraya koenigii (L.) have resulted in the isolation of six carbazole alkaloids which have been identified as mahanimbine (1), girinimbine (2), murrayacine (3), murrayanine (4), murrayafoline-A (5) and 3-methylcarbazole (6) together with b-sitosterol. The...
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| Format: | Article |
| Language: | English English |
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Chemic Publishing Company
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30151/ http://psasir.upm.edu.my/id/eprint/30151/1/Larvicidal%20carbazole%20alkaloids%20from%20Murraya%20koenigii%20against%20dengue%20fever%20mosquito%20Aedes%20aegypti%20Linnaeus.pdf |
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| author | Md.Sukari, Mohd. Aspollah Mohd Noor, Halimatul Saadiah Abu Bakar, Nur Haslizawati Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Rahmani, Mawardi Abdul, Ahmad Bustamam |
| author_facet | Md.Sukari, Mohd. Aspollah Mohd Noor, Halimatul Saadiah Abu Bakar, Nur Haslizawati Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Rahmani, Mawardi Abdul, Ahmad Bustamam |
| author_sort | Md.Sukari, Mohd. Aspollah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Phytochemical studies on different parts of Murraya koenigii (L.) have resulted in the isolation of six carbazole alkaloids which have been identified as mahanimbine (1), girinimbine (2), murrayacine (3), murrayanine (4), murrayafoline-A (5) and 3-methylcarbazole (6) together with b-sitosterol. The structures of these compounds were established using spectroscopic techniques. The crude extracts and chemical constituents obtained from the isolation work were tested on its larvicidal activity against dengue fever mosquito, Aedes aegypti. Hexane extract from stem bark, roots and leaves of Murraya koenigii showed strong activity against Aedes aegypti followed by chloroform extract of the roots and leaves. Methanol extract of the leaves also showed strong activity while methanol extract of the roots showed moderate activity. Besides, chloroform and methanol extracts from stem bark showed strong activity. Similarly, pure compounds isolated from the plant, mahanimbine (1), girinimbine (2), murrayacine (3), murrayanine (4) and murrayafoline A (5) exhibited strong activity against Aedes aegypti with LC50 values of less than 3 μg/mL. |
| first_indexed | 2025-11-15T09:05:14Z |
| format | Article |
| id | upm-30151 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:05:14Z |
| publishDate | 2013 |
| publisher | Chemic Publishing Company |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-301512015-10-08T04:13:09Z http://psasir.upm.edu.my/id/eprint/30151/ Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus Md.Sukari, Mohd. Aspollah Mohd Noor, Halimatul Saadiah Abu Bakar, Nur Haslizawati Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Rahmani, Mawardi Abdul, Ahmad Bustamam Phytochemical studies on different parts of Murraya koenigii (L.) have resulted in the isolation of six carbazole alkaloids which have been identified as mahanimbine (1), girinimbine (2), murrayacine (3), murrayanine (4), murrayafoline-A (5) and 3-methylcarbazole (6) together with b-sitosterol. The structures of these compounds were established using spectroscopic techniques. The crude extracts and chemical constituents obtained from the isolation work were tested on its larvicidal activity against dengue fever mosquito, Aedes aegypti. Hexane extract from stem bark, roots and leaves of Murraya koenigii showed strong activity against Aedes aegypti followed by chloroform extract of the roots and leaves. Methanol extract of the leaves also showed strong activity while methanol extract of the roots showed moderate activity. Besides, chloroform and methanol extracts from stem bark showed strong activity. Similarly, pure compounds isolated from the plant, mahanimbine (1), girinimbine (2), murrayacine (3), murrayanine (4) and murrayafoline A (5) exhibited strong activity against Aedes aegypti with LC50 values of less than 3 μg/mL. Chemic Publishing Company 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30151/1/Larvicidal%20carbazole%20alkaloids%20from%20Murraya%20koenigii%20against%20dengue%20fever%20mosquito%20Aedes%20aegypti%20Linnaeus.pdf Md.Sukari, Mohd. Aspollah and Mohd Noor, Halimatul Saadiah and Abu Bakar, Nur Haslizawati and Ee, Gwendoline Cheng Lian and Ismail, Intan Safinar and Rahmani, Mawardi and Abdul, Ahmad Bustamam (2013) Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus. Asian Journal of Chemistry, 25 (14). pp. 7719-7721. ISSN 0970-7077 http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=25_15_13 English |
| spellingShingle | Md.Sukari, Mohd. Aspollah Mohd Noor, Halimatul Saadiah Abu Bakar, Nur Haslizawati Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Rahmani, Mawardi Abdul, Ahmad Bustamam Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus |
| title | Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus |
| title_full | Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus |
| title_fullStr | Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus |
| title_full_unstemmed | Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus |
| title_short | Larvicidal carbazole alkaloids from Murraya koenigii against dengue fever mosquito Aedes aegypti Linnaeus |
| title_sort | larvicidal carbazole alkaloids from murraya koenigii against dengue fever mosquito aedes aegypti linnaeus |
| url | http://psasir.upm.edu.my/id/eprint/30151/ http://psasir.upm.edu.my/id/eprint/30151/ http://psasir.upm.edu.my/id/eprint/30151/1/Larvicidal%20carbazole%20alkaloids%20from%20Murraya%20koenigii%20against%20dengue%20fever%20mosquito%20Aedes%20aegypti%20Linnaeus.pdf |