Antileukemic activity of extracts and constituents of Aegle marmelos
Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7),...
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| Format: | Article |
| Language: | English English |
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International Congress of Chemistry and Environment
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30038/ http://psasir.upm.edu.my/id/eprint/30038/1/Antileukemic%20activity%20of%20extracts%20and%20constituents%20of%20Aegle%20marmelos.pdf |
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| author | Mustahil, Noorul Adawiyah Riyanto, Sugeng Rahmani, Mawardi Mohd Nor, Siti Mariam Ali, Abdul Manaf |
| author_facet | Mustahil, Noorul Adawiyah Riyanto, Sugeng Rahmani, Mawardi Mohd Nor, Siti Mariam Ali, Abdul Manaf |
| author_sort | Mustahil, Noorul Adawiyah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7), epoxyauraptene (8) and marmin (9) together with β-sitosterol and stigmasterol. All crude extracts and isolated compounds were examined for their antileukemic activity against CEM-SS (human T-lymphoblastic leukemia) cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Roots extracts exhibited significant cytotoxicity while leaves and stem bark extracts were inactive. Hopane triterpenes; zeorin (1) and dustanin (2) as well as alkaloid aegeline (5) isolated from leaves exhibited moderate to strong cytotoxicity with dustanin (2) as the most active constituent (IC50 : 5.3±0.24 μg/mL). Lupane triterpenes; epilupeol (3) and lupenone (4), in addition of coumarin derivative; marmin (9) isolated from stem bark also demonstrated moderate to strong cytotoxicity with epilupeol (3) showed significant activity (IC50 : 6.1±0.20 μg/mL). The chemical constituents isolated from roots were inactive except for epilupeol (3) and marmin (9) which have also been isolated from stem bark. |
| first_indexed | 2025-11-15T09:04:44Z |
| format | Article |
| id | upm-30038 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:04:44Z |
| publishDate | 2013 |
| publisher | International Congress of Chemistry and Environment |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-300382015-10-07T23:45:44Z http://psasir.upm.edu.my/id/eprint/30038/ Antileukemic activity of extracts and constituents of Aegle marmelos Mustahil, Noorul Adawiyah Riyanto, Sugeng Rahmani, Mawardi Mohd Nor, Siti Mariam Ali, Abdul Manaf Phytochemicals study of various parts of Aegle marmelos (leaves, stem bark and roots) have afforded eleven compounds; hopane and lupane triterpenes including zeorin (1), dustanin (2) also epilupeol (3) and lupenone (4); alkaloids aegeline (5) and skimmianine (6); coumarin derivatives; auraptene (7), epoxyauraptene (8) and marmin (9) together with β-sitosterol and stigmasterol. All crude extracts and isolated compounds were examined for their antileukemic activity against CEM-SS (human T-lymphoblastic leukemia) cancer cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Roots extracts exhibited significant cytotoxicity while leaves and stem bark extracts were inactive. Hopane triterpenes; zeorin (1) and dustanin (2) as well as alkaloid aegeline (5) isolated from leaves exhibited moderate to strong cytotoxicity with dustanin (2) as the most active constituent (IC50 : 5.3±0.24 μg/mL). Lupane triterpenes; epilupeol (3) and lupenone (4), in addition of coumarin derivative; marmin (9) isolated from stem bark also demonstrated moderate to strong cytotoxicity with epilupeol (3) showed significant activity (IC50 : 6.1±0.20 μg/mL). The chemical constituents isolated from roots were inactive except for epilupeol (3) and marmin (9) which have also been isolated from stem bark. International Congress of Chemistry and Environment 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30038/1/Antileukemic%20activity%20of%20extracts%20and%20constituents%20of%20Aegle%20marmelos.pdf Mustahil, Noorul Adawiyah and Riyanto, Sugeng and Rahmani, Mawardi and Mohd Nor, Siti Mariam and Ali, Abdul Manaf (2013) Antileukemic activity of extracts and constituents of Aegle marmelos. Research Journal of Chemistry and Environment, 17 (1). pp. 62-67. ISSN 0972-0626 English |
| spellingShingle | Mustahil, Noorul Adawiyah Riyanto, Sugeng Rahmani, Mawardi Mohd Nor, Siti Mariam Ali, Abdul Manaf Antileukemic activity of extracts and constituents of Aegle marmelos |
| title | Antileukemic activity of extracts and constituents of Aegle marmelos |
| title_full | Antileukemic activity of extracts and constituents of Aegle marmelos |
| title_fullStr | Antileukemic activity of extracts and constituents of Aegle marmelos |
| title_full_unstemmed | Antileukemic activity of extracts and constituents of Aegle marmelos |
| title_short | Antileukemic activity of extracts and constituents of Aegle marmelos |
| title_sort | antileukemic activity of extracts and constituents of aegle marmelos |
| url | http://psasir.upm.edu.my/id/eprint/30038/ http://psasir.upm.edu.my/id/eprint/30038/1/Antileukemic%20activity%20of%20extracts%20and%20constituents%20of%20Aegle%20marmelos.pdf |