Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines.
The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deox...
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| Format: | Article |
| Language: | English English |
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MDPI
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/30008/ http://psasir.upm.edu.my/id/eprint/30008/1/Cytotoxicity%20and%20structure.pdf |
| _version_ | 1848846557351247872 |
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| author | Teh, Soek Sin Ee, Gwendoline Cheng Lian Mah, Siau Hui Lim, Yang Mooi Ahmad, Zuraini |
| author_facet | Teh, Soek Sin Ee, Gwendoline Cheng Lian Mah, Siau Hui Lim, Yang Mooi Ahmad, Zuraini |
| author_sort | Teh, Soek Sin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities. |
| first_indexed | 2025-11-15T09:04:36Z |
| format | Article |
| id | upm-30008 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:04:36Z |
| publishDate | 2013 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-300082015-12-29T03:54:56Z http://psasir.upm.edu.my/id/eprint/30008/ Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. Teh, Soek Sin Ee, Gwendoline Cheng Lian Mah, Siau Hui Lim, Yang Mooi Ahmad, Zuraini The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone (1), mesuasinone (2), mesuaferrin A (3), mesuaferrin B (4), mesuaferrin C (5), 6-deoxyjacareubin (6), caloxanthone C (7), macluraxanthone (8), 1,5-dihydroxyxanthone (9), tovopyrifolin C (10) and α-mangostin (11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A (3), macluraxanthone (8) and α-mangostin (11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities. MDPI 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30008/1/Cytotoxicity%20and%20structure.pdf Teh, Soek Sin and Ee, Gwendoline Cheng Lian and Mah, Siau Hui and Lim, Yang Mooi and Ahmad, Zuraini (2013) Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. Molecules, 18 (2). pp. 1985-1994. ISSN 1431-5157; ESSN: 1420-3049 http://www.mdpi.com/1420-3049/18/2 10.3390/molecules18021985 English |
| spellingShingle | Teh, Soek Sin Ee, Gwendoline Cheng Lian Mah, Siau Hui Lim, Yang Mooi Ahmad, Zuraini Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. |
| title | Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. |
| title_full | Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. |
| title_fullStr | Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. |
| title_full_unstemmed | Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. |
| title_short | Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. |
| title_sort | cytotoxicity and structure-activity relationships of xanthone derivatives from mesua beccariana, mesua ferrea and mesua congestiflora towards nine human cancer cell lines. |
| url | http://psasir.upm.edu.my/id/eprint/30008/ http://psasir.upm.edu.my/id/eprint/30008/ http://psasir.upm.edu.my/id/eprint/30008/ http://psasir.upm.edu.my/id/eprint/30008/1/Cytotoxicity%20and%20structure.pdf |