Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds
Objective: To evaluate the osteogenic potential of avian demineralized bone matrix (DBM) in the context of implant geometry. Study Design: Experimental. Animals: Rock pigeons (n = 24). Methods: Tubular and chipped forms of DBM were prepared by acid demineralization of long bones from healthy allogen...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The American College of Veterinary Surgeons
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/29930/ http://psasir.upm.edu.my/id/eprint/29930/1/29930.pdf |
| _version_ | 1848846535325908992 |
|---|---|
| author | Sanaei, Mohamadreza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah |
| author_facet | Sanaei, Mohamadreza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah |
| author_sort | Sanaei, Mohamadreza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: To evaluate the osteogenic potential of avian demineralized bone matrix (DBM) in the context of implant geometry. Study Design: Experimental. Animals: Rock pigeons (n = 24). Methods: Tubular and chipped forms of DBM were prepared by acid demineralization of long bones from healthy allogeneic donors and implanted bilaterally into the pectoral region of 24 pigeons. After euthanasia at 1, 4, 6, 8, 10, and 12 weeks, explants were evaluated histologically and compared by means of quantitative (bone area) and semi quantitative measures (scores). Results: All explants had new bone at retrieval with the exception of tubular implants at the end of week 1. The most reactive part in both implants was the interior region between the periosteal and endosteal surfaces followed by the area at the implant-muscle interface. Quantitative measurements demonstrated a significantly (P = .012) greater percentage of new bone formation induced by tubular implants (80.28 ± 8.94) compared with chip implants (57.64 ± 3.12). There was minimal inflammation. Conclusions: Avian DBM initiates heterotopic bone formation in allogeneic recipients with low grades of immunogenicity. Implant geometry affects this phenomenon as osteoconduction appeared to augment the magnitude of the effects in larger tubular implants. |
| first_indexed | 2025-11-15T09:04:15Z |
| format | Article |
| id | upm-29930 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:04:15Z |
| publishDate | 2013 |
| publisher | The American College of Veterinary Surgeons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-299302016-11-16T05:03:37Z http://psasir.upm.edu.my/id/eprint/29930/ Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds Sanaei, Mohamadreza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah Objective: To evaluate the osteogenic potential of avian demineralized bone matrix (DBM) in the context of implant geometry. Study Design: Experimental. Animals: Rock pigeons (n = 24). Methods: Tubular and chipped forms of DBM were prepared by acid demineralization of long bones from healthy allogeneic donors and implanted bilaterally into the pectoral region of 24 pigeons. After euthanasia at 1, 4, 6, 8, 10, and 12 weeks, explants were evaluated histologically and compared by means of quantitative (bone area) and semi quantitative measures (scores). Results: All explants had new bone at retrieval with the exception of tubular implants at the end of week 1. The most reactive part in both implants was the interior region between the periosteal and endosteal surfaces followed by the area at the implant-muscle interface. Quantitative measurements demonstrated a significantly (P = .012) greater percentage of new bone formation induced by tubular implants (80.28 ± 8.94) compared with chip implants (57.64 ± 3.12). There was minimal inflammation. Conclusions: Avian DBM initiates heterotopic bone formation in allogeneic recipients with low grades of immunogenicity. Implant geometry affects this phenomenon as osteoconduction appeared to augment the magnitude of the effects in larger tubular implants. The American College of Veterinary Surgeons 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29930/1/29930.pdf Sanaei, Mohamadreza and Abu, Jalila and Nazari, Mojgan and Abu Bakar @ Zakaria, Md Zuki and Allaudin, Zeenathul Nazariah (2013) Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds. Veterinary Surgery, 42 (8). pp. 963-970. ISSN 0161-3499; ESSN: 1532-950X 10.1111/j.1532-950X.2013.12057.x |
| spellingShingle | Sanaei, Mohamadreza Abu, Jalila Nazari, Mojgan Abu Bakar @ Zakaria, Md Zuki Allaudin, Zeenathul Nazariah Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds |
| title | Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds |
| title_full | Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds |
| title_fullStr | Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds |
| title_full_unstemmed | Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds |
| title_short | Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds |
| title_sort | qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds |
| url | http://psasir.upm.edu.my/id/eprint/29930/ http://psasir.upm.edu.my/id/eprint/29930/ http://psasir.upm.edu.my/id/eprint/29930/1/29930.pdf |