Thymoquinone-loaded nonostructured lipid carriers : preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration

QR Code

Thymoquinone-loaded nonostructured lipid carriers : preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration

Background: Nanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. Thymoquinone is the main bioactive compound of Nigella sativa. In this study, the preparation, gastroprotective effects, and pharmacokinetic (PK) prope...

Full description

Bibliographic Details
Main Authors:	Abdelwahab, Siddig Ibrahim, Sheikh, Bassem Yousef, Elhassan Taha, Manal Mohamed, Chee, Wun How, Abdullah, Rasedee, Yagoub, Umar, El-Sunousi, Rashad, Eid, Elthayeb E. M.
Format:	Article
Language:	English
Published:	Dove Medical Press 2013
Online Access:	http://psasir.upm.edu.my/id/eprint/29891/ http://psasir.upm.edu.my/id/eprint/29891/1/Thymoquinone.pdf

Similar Items

Thymoquinone loaded nanostructured lipid carriers (TQ-NLC) and uses thereof
by: Saiful Yazan, Latifah, et al.
Published: (2012)

Effect of thymoquinone and thymoquinone-loaded nanostructured lipid carrier in in vitro wound healing model
by: Alexander, Henna Roshini
Published: (2019)

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume
by: Sidahmed, Heyam Mohamed Ali, et al.
Published: (2016)

Pharmacokinetics, biodistribution and neuroprotective effects of thymoquinone-loaded nanostructured lipid carrier on high fat cholesterol diet induced Alzheimer's disease rat model
by: Zakarial Ansar, Fatin Hannani
Published: (2022)

Cytotoxicity of thymoquinone and thymoquinone-loaded nanostrustured lipid carrier on cervical cancer cells (SiHa and HeLa)
by: Ng, Wei Keat
Published: (2015)

Migration and proliferation effects of Thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) and Thymoquinone (TQ) on in vitro wound healing models
by: Alexander, Henna Roshini, et al.
Published: (2019)

Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80
by: How, Chee Wun, et al.
Published: (2011)

Effects of thymoquinone and thymoquinone-loaded nanostructured lipid carrier on hepatocellular carcinoma cell models, Hep3B and HepG2
by: Haron, Aminah Suhaila
Published: (2017)

Acrylated vegetable oil nanoparticle as a carrier and controlled release of the anticancer drug-thymoquinone
by: Tajau, Rida, et al.

Toxicity and anti-breast cancer properties of thymoquinone-loaded nanostructured lipid carrier in mice
by: Ong, Yong Sze
Published: (2019)

Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa)
by: Wei, Keat Ng, et al.
Published: (2015)

Mechanism(s) of action involved in the gastroprotective activity of Muntingia calabura
by: Zakaria, Zainul Amiruddin, et al.
Published: (2014)

Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves
by: Zakaria, Zainul Amiruddin, et al.
Published: (2015)

Thymoquinone-loaded nanostructured lipid carrier reduces proliferation of human liver cancer cells, HepG2
by: Mustafa Azmy, Nurfahima, et al.
Published: (2019)

Acute and sub-acute toxicity profile of thymoquinone-loaded nanostructured lipid carrier (TQNLC) in BALB/c mice
by: Yong, Sze Ong, et al.
Published: (2016)

Characterization and cytotoxicty of nanostructured lipid carriers formulated with olive oil, hydrogenated palm oil and polysorbate 80.
by: How, Chee Wun, et al.
Published: (2013)

Preparation, characterization, and preliminary pharmacokinetic studies on complex of zerumbone with hydroxypropyl-ß-cyclodeetrin
by: Mohammad Eid, Eltayeb Elamin
Published: (2012)

Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats
by: Saiful Yazan, Latifah, et al.
Published: (2019)

Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo
by: Sidahmed, Heyam M. A., et al.
Published: (2013)

Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity
by: How, Chee Wun, et al.
Published: (2013)

Evaluation of gastroprotective effects of the ethanolic extract of Peperomia pellucida (L) Kunth
by: Abd Hamid @ Abdul Razak, Roslida, et al.
Published: (2009)

Gastroprotective effect of Acanthopanax trifoliatus on experimentally induced acute ulcer in rats
by: Abd Hamid @ Abdul Razak, Roslida, et al.
Published: (2010)

Gastroprotective activity of chloroform extract of Muntingia calabura and Melastoma malabathricum leaves
by: Zakaria, Zainul Amiruddin, et al.
Published: (2016)

Mode of action for gastroprotective activity of Muntingia calabura L. leaves in rats
by: Balan, Tavamani
Published: (2016)

Neuroprotective effects of thymoquinone-rich fraction and thymoquinone nanoemulsions in sporadic alzheimer’s disease rat model
by: Ismail, Norsharina
Published: (2019)

Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats
by: Somchit, M. N., et al.
Published: (2007)

Combination of zerumbone and cisplatin to treat cervical intraepithelial neoplasia in female BALB/c mice.
by: Abdul, Ahmad Bustamam, et al.
Published: (2009)

Liquid chromatography - tandem mass spectroscopic method for the determination Of zerumbone in human plasma and its application to Pharmacokinetics
by: Abdul, Ahmad Bustamam, et al.
Published: (2011)

Cytotoxicity effect of Thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) on liver cancer cell integrated with hepatitis B genome, Hep3B
by: Haron, Aminah Suhaila, et al.
Published: (2018)

Thymoquinone rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon and leukemic carcinoma cell lines.
by: Ismail, Norsharina, et al.
Published: (2011)

Improvement of gastroprotective and anti-ulcer effect of kenaf seed oil-in-water nanoemulsions in rats
by: Cheong, Ai Mun, et al.
Published: (2018)

Gastroprotective Effect of Tabernaemontana divaricata (L). R.Br. Flower Methanolic Extract in Rats.
by: Zakaria, Zainul Amiruddin, et al.
Published: (2011)

Gastroprotective activity and mechanisms of action of Bauhinia purpurea Linn (Leguminoseae) leaf methanol extract
by: Kamarolzaman, M. F. F., et al.
Published: (2014)

In vitro ultramorphological assessment of apoptosis induced by Zerumbone on (HeLa)
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)

Oncolysis of breast, liver and leukemia cancer cells using ethyl acetate and methanol extracts of goniothalamus umbrosus.
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)

Energy-dispersive x-ray microanalysis of elements’ content and antimicrobial properties of Pereskia bleo and Goniothalamus umbrosus
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)

Energy-dispersive x-ray microanalysis of elements' content of medicinal plants used traditionally as anticancer cure
by: Abdelwahab, Siddig Ibrahim, et al.
Published: (2009)

Antitumor Effect of Zerumbone Isolated from Lempoyang (Zingiber Zerumbet) on Human Cervical Cancer Cells and Mouse Cervical Intraepithelial Neoplasia
by: Abdelwahab, Siddig Ibrahim
Published: (2009)

Regulation of Apolipoprotein A-1 and Apolipoprotein B100 Genes by Thymoquinone Rich Fraction and Thymoquinone in HEPG2 Cells.
by: Al Naqeeb, Ghanya, et al.
Published: (2009)

Thymoquinone: Potential cure for inflammatory disorders and cancer
by: Woo, C., et al.
Published: (2012)