Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios
Background: Polyunsaturated fatty acids (PUFA) play important roles in brain fatty acid composition and behavior through their effects on neuronal properties and gene expression. The hippocampus plays an important role in the formation of memory, especially spatial memory and navigation. This study...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/29860/ http://psasir.upm.edu.my/id/eprint/29860/1/Alterations%20in%20neuronal%20morphology%20and%20synaptophysin%20expression%20in%20the%20rat%20brain%20as%20a%20result%20of%20changes%20in%20dietary%20n.pdf |
| _version_ | 1848846516529135616 |
|---|---|
| author | Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Tan, Ai Li Ebrahimi, Mahdi |
| author_facet | Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Tan, Ai Li Ebrahimi, Mahdi |
| author_sort | Hajjar, Toktam |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Polyunsaturated fatty acids (PUFA) play important roles in brain fatty acid composition and behavior through their effects on neuronal properties and gene expression. The hippocampus plays an important role in the formation of memory, especially spatial memory and navigation. This study was conducted to examine the effects of PUFA and specifically different dietary n-6: n-3 fatty acid ratios (FAR) on the number and size of hippocampal neurons and the expression of synaptophysin protein in the hippocampus of rats. Methods: Forty 3-week old male Sprague–Dawley rats were allotted into 4 groups. The animals received experimental diets with different n-6: n-3 FAR of either 65:1, 26.5:1, 22:1 or 4.5:1 for 14 weeks. Results: The results showed that a lowering dietary n-6: n-3 FAR supplementation can increase the number and size of neurons. Moreover, lowering the dietary n-6: n-3 FAR led to an increase in the expression of the pre-synaptic protein synaptophysin in the CA1 hippocampal subregion of the rat brain. Conclusions: These findings support the notion that decreasing the dietary n-6: n-3 FAR will lead to an intensified hippocampal synaptophysin expression and increased neuron size and proliferation in the rat brain. |
| first_indexed | 2025-11-15T09:03:57Z |
| format | Article |
| id | upm-29860 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:57Z |
| publishDate | 2013 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-298602015-09-11T00:41:29Z http://psasir.upm.edu.my/id/eprint/29860/ Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Tan, Ai Li Ebrahimi, Mahdi Background: Polyunsaturated fatty acids (PUFA) play important roles in brain fatty acid composition and behavior through their effects on neuronal properties and gene expression. The hippocampus plays an important role in the formation of memory, especially spatial memory and navigation. This study was conducted to examine the effects of PUFA and specifically different dietary n-6: n-3 fatty acid ratios (FAR) on the number and size of hippocampal neurons and the expression of synaptophysin protein in the hippocampus of rats. Methods: Forty 3-week old male Sprague–Dawley rats were allotted into 4 groups. The animals received experimental diets with different n-6: n-3 FAR of either 65:1, 26.5:1, 22:1 or 4.5:1 for 14 weeks. Results: The results showed that a lowering dietary n-6: n-3 FAR supplementation can increase the number and size of neurons. Moreover, lowering the dietary n-6: n-3 FAR led to an increase in the expression of the pre-synaptic protein synaptophysin in the CA1 hippocampal subregion of the rat brain. Conclusions: These findings support the notion that decreasing the dietary n-6: n-3 FAR will lead to an intensified hippocampal synaptophysin expression and increased neuron size and proliferation in the rat brain. BioMed Central 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29860/1/Alterations%20in%20neuronal%20morphology%20and%20synaptophysin%20expression%20in%20the%20rat%20brain%20as%20a%20result%20of%20changes%20in%20dietary%20n.pdf Hajjar, Toktam and Goh, Yong Meng and Rajion, Mohamed Ali and Vidyadaran, Sharmili and Tan, Ai Li and Ebrahimi, Mahdi (2013) Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios. Lipids in Health and Disease, 12. art. no. 113. pp. 1-9. ISSN 1476-511X http://www.lipidworld.com/content/pdf/1476-511X-12-113.pdf 10.1186/1476-511X-12-113 |
| spellingShingle | Hajjar, Toktam Goh, Yong Meng Rajion, Mohamed Ali Vidyadaran, Sharmili Tan, Ai Li Ebrahimi, Mahdi Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios |
| title | Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios |
| title_full | Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios |
| title_fullStr | Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios |
| title_full_unstemmed | Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios |
| title_short | Alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios |
| title_sort | alterations in neuronal morphology and synaptophysin expression in the rat brain as a result of changes in dietary n-6: n-3 fatty acid ratios |
| url | http://psasir.upm.edu.my/id/eprint/29860/ http://psasir.upm.edu.my/id/eprint/29860/ http://psasir.upm.edu.my/id/eprint/29860/ http://psasir.upm.edu.my/id/eprint/29860/1/Alterations%20in%20neuronal%20morphology%20and%20synaptophysin%20expression%20in%20the%20rat%20brain%20as%20a%20result%20of%20changes%20in%20dietary%20n.pdf |