Diuretic activity of roots from Carica papaya L. and Ananas comosus L.
Water extracts of Carica papaya and Ananas comosus extracts were administered orally at doses of 5 and 10 mg/kg to Spraque Dawley rats. Two other groups were given commercial diuretics, furosemide and hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were d...
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| Format: | Article |
| Language: | English |
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Global Research Online Publishing House
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29830/ http://psasir.upm.edu.my/id/eprint/29830/1/Diuretic%20activity%20of%20roots%20from%20Carica%20papaya%20L.pdf |
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| author | Adam, Yunus Abdul Aziz, Nasaruddin Ahmad, Zuraini Abd. Kadir, Arifah Omar Fauzee, Mohd Sofian Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul |
| author_facet | Adam, Yunus Abdul Aziz, Nasaruddin Ahmad, Zuraini Abd. Kadir, Arifah Omar Fauzee, Mohd Sofian Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul |
| author_sort | Adam, Yunus |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Water extracts of Carica papaya and Ananas comosus extracts were administered orally at doses of 5 and 10 mg/kg to Spraque Dawley rats. Two other groups were given commercial diuretics, furosemide and hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were determined every hour for 4 hours. Blood was taken to determine the serum level of glucose, albumin, blood urea nitrogen (BUN) and creatinine. Both, C. papaya and A. comosus extracts exhibited moderate to potent diuretic activity. C. papaya extract increased the 4-hour urine volume when administered at both 5 and 10 mg/kg. A. comosus extracts increased urine volume only at 10 mg/kg dose. Na+ and Cl- elimination was unchanged for the whole period of study. However, the 4-hour urinary excretions of K+ were significantly increased for both plant extracts. Both plant extracts induced increment of serum BUN and creatinine level significantly when compared to controls (p<0.05) but these levels were still within the normal range. Blood glucose level and albumin were not significantly for both plant extract. In conclusion, both plants investigated had diuretic activity and roots of C. papaya activity were statistically similar potency to the activity of furosemide and hydrochlorothiazide. However, care must be taken when using these herbs as increased urinary K+ being excreted and marginal increase of serum BUN and creatinine were detected. |
| first_indexed | 2025-11-15T09:03:49Z |
| format | Article |
| id | upm-29830 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:49Z |
| publishDate | 2013 |
| publisher | Global Research Online Publishing House |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-298302015-10-27T06:13:13Z http://psasir.upm.edu.my/id/eprint/29830/ Diuretic activity of roots from Carica papaya L. and Ananas comosus L. Adam, Yunus Abdul Aziz, Nasaruddin Ahmad, Zuraini Abd. Kadir, Arifah Omar Fauzee, Mohd Sofian Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul Water extracts of Carica papaya and Ananas comosus extracts were administered orally at doses of 5 and 10 mg/kg to Spraque Dawley rats. Two other groups were given commercial diuretics, furosemide and hydrochlorthiazide at 10 mg/kg. Urine volume, urine pH, urine density and urine electrolytes were determined every hour for 4 hours. Blood was taken to determine the serum level of glucose, albumin, blood urea nitrogen (BUN) and creatinine. Both, C. papaya and A. comosus extracts exhibited moderate to potent diuretic activity. C. papaya extract increased the 4-hour urine volume when administered at both 5 and 10 mg/kg. A. comosus extracts increased urine volume only at 10 mg/kg dose. Na+ and Cl- elimination was unchanged for the whole period of study. However, the 4-hour urinary excretions of K+ were significantly increased for both plant extracts. Both plant extracts induced increment of serum BUN and creatinine level significantly when compared to controls (p<0.05) but these levels were still within the normal range. Blood glucose level and albumin were not significantly for both plant extract. In conclusion, both plants investigated had diuretic activity and roots of C. papaya activity were statistically similar potency to the activity of furosemide and hydrochlorothiazide. However, care must be taken when using these herbs as increased urinary K+ being excreted and marginal increase of serum BUN and creatinine were detected. Global Research Online Publishing House 2013-11 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29830/1/Diuretic%20activity%20of%20roots%20from%20Carica%20papaya%20L.pdf Adam, Yunus and Abdul Aziz, Nasaruddin and Ahmad, Zuraini and Abd. Kadir, Arifah and Omar Fauzee, Mohd Sofian and Zakaria, Zainul Amiruddin and Somchit, Muhammad Nazrul (2013) Diuretic activity of roots from Carica papaya L. and Ananas comosus L. International Journal of Pharmaceutical Sciences Review and Research, 23 (1). art. no. 32. pp. 163-167. ISSN 0976-044X http://www.globalresearchonline.net/pharmajournal/vol23iss1.aspx |
| spellingShingle | Adam, Yunus Abdul Aziz, Nasaruddin Ahmad, Zuraini Abd. Kadir, Arifah Omar Fauzee, Mohd Sofian Zakaria, Zainul Amiruddin Somchit, Muhammad Nazrul Diuretic activity of roots from Carica papaya L. and Ananas comosus L. |
| title | Diuretic activity of roots from Carica papaya L. and Ananas comosus L. |
| title_full | Diuretic activity of roots from Carica papaya L. and Ananas comosus L. |
| title_fullStr | Diuretic activity of roots from Carica papaya L. and Ananas comosus L. |
| title_full_unstemmed | Diuretic activity of roots from Carica papaya L. and Ananas comosus L. |
| title_short | Diuretic activity of roots from Carica papaya L. and Ananas comosus L. |
| title_sort | diuretic activity of roots from carica papaya l. and ananas comosus l. |
| url | http://psasir.upm.edu.my/id/eprint/29830/ http://psasir.upm.edu.my/id/eprint/29830/ http://psasir.upm.edu.my/id/eprint/29830/1/Diuretic%20activity%20of%20roots%20from%20Carica%20papaya%20L.pdf |