Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers
Aging is attributed to both genetic and environmental factors. Occupational exposure is one of the environmental factors with potential genotoxic effects. Researchers try to determine factors involved in genetic damages at hazards exposure that could accelerate aging. Cytochrome P450 2E1 (CYP2E1) ge...
| Main Authors: | , , , , |
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| Format: | Article |
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Taylor & Francis
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29808/ |
| _version_ | 1848846502293667840 |
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| author | Eshkoor, Sima Ataollahi Ismail, Patimah Abdul Rahman, Sabariah Adon, Mohd Yusoff Vasudevan, Ramachandran |
| author_facet | Eshkoor, Sima Ataollahi Ismail, Patimah Abdul Rahman, Sabariah Adon, Mohd Yusoff Vasudevan, Ramachandran |
| author_sort | Eshkoor, Sima Ataollahi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Aging is attributed to both genetic and environmental factors. Occupational exposure is one of the environmental factors with potential genotoxic effects. Researchers try to determine factors involved in genetic damages at hazards exposure that could accelerate aging. Cytochrome P450 2E1 (CYP2E1) gene contributes in activation and detoxification of the environmental hazards. This polymorphism plays an important role in susceptibility of inter-individuals to DNA damage at the occupational exposure. The current study evaluated the possible influence of this gene polymorphism in aging by genomic damages through the biomarkers alterations of micronuclei (MN), comet tail length and telomere length shortening at the exposure. In this study, buccal cells were collected from the oral cavity of exposed workers and non-exposed controls. The CYP2E1 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The wild genotype significantly affected MN frequency (p=0.007) and relative telomere length (p=0.047) in the older group of workers. It was concluded that the interaction of gene polymorphism and exposure enhances DNA damage and accelerates aging consequently. |
| first_indexed | 2025-11-15T09:03:44Z |
| format | Article |
| id | upm-29808 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T09:03:44Z |
| publishDate | 2013 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-298082016-02-19T02:25:46Z http://psasir.upm.edu.my/id/eprint/29808/ Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers Eshkoor, Sima Ataollahi Ismail, Patimah Abdul Rahman, Sabariah Adon, Mohd Yusoff Vasudevan, Ramachandran Aging is attributed to both genetic and environmental factors. Occupational exposure is one of the environmental factors with potential genotoxic effects. Researchers try to determine factors involved in genetic damages at hazards exposure that could accelerate aging. Cytochrome P450 2E1 (CYP2E1) gene contributes in activation and detoxification of the environmental hazards. This polymorphism plays an important role in susceptibility of inter-individuals to DNA damage at the occupational exposure. The current study evaluated the possible influence of this gene polymorphism in aging by genomic damages through the biomarkers alterations of micronuclei (MN), comet tail length and telomere length shortening at the exposure. In this study, buccal cells were collected from the oral cavity of exposed workers and non-exposed controls. The CYP2E1 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The wild genotype significantly affected MN frequency (p=0.007) and relative telomere length (p=0.047) in the older group of workers. It was concluded that the interaction of gene polymorphism and exposure enhances DNA damage and accelerates aging consequently. Taylor & Francis 2013-05 Article PeerReviewed Eshkoor, Sima Ataollahi and Ismail, Patimah and Abdul Rahman, Sabariah and Adon, Mohd Yusoff and Vasudevan, Ramachandran (2013) Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers. Toxicology Mechanisms and Methods, 23 (4). pp. 217-222. ISSN 1537-6516; ESSN: 1537-6524 http://www.tandfonline.com/doi/abs/10.3109/15376516.2012.743637?journalCode=itxm20 10.3109/15376516.2012.743637 |
| spellingShingle | Eshkoor, Sima Ataollahi Ismail, Patimah Abdul Rahman, Sabariah Adon, Mohd Yusoff Vasudevan, Ramachandran Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers |
| title | Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers |
| title_full | Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers |
| title_fullStr | Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers |
| title_full_unstemmed | Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers |
| title_short | Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers |
| title_sort | contribution of cyp2e1 polymorphism to aging in the mechanical workshop workers |
| url | http://psasir.upm.edu.my/id/eprint/29808/ http://psasir.upm.edu.my/id/eprint/29808/ http://psasir.upm.edu.my/id/eprint/29808/ |