Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period
Jatropha curcas is a species of flowering plants in the spurge family, Euphorbiaceae. The seeds contain 27-40% oil consisting of curcin and tetramethylpyrazine which are toxic and cause abortion, fetotoxicity and teratogenic effects if consume during pregnancy. Twenty four Sprague dawley rats at e...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Institute for Science, Technology & Education
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/29789/ http://psasir.upm.edu.my/id/eprint/29789/1/Anti%20implantation%20effects%20of%20Jatropha%20curcas%20crude%20oil%20when%20fed%20to%20pregnant%20Sprague%20dawley%20rats%20during%20the%20early%20gestation%20period.pdf |
| _version_ | 1848846497200734208 |
|---|---|
| author | Alwi, Nur Azira Sukardi, Sabrina |
| author_facet | Alwi, Nur Azira Sukardi, Sabrina |
| author_sort | Alwi, Nur Azira |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Jatropha curcas is a species of flowering plants in the spurge family, Euphorbiaceae. The seeds contain 27-40%
oil consisting of curcin and tetramethylpyrazine which are toxic and cause abortion, fetotoxicity and teratogenic
effects if consume during pregnancy. Twenty four Sprague dawley rats at early gestation weighing about 200- 300g were randomized into four groups: Positive control group was orally administered with retinyl palmitate, negative control group with corn oil (vehicle), treatment group with 0.7 ml/kg body weight of the oil and the normal group was given distilled water. Females were paired overnight with male rats and presence of sperm in the vaginal smears indicated positive mating and considered pregnant day 1. Rats were dosed orally once daily from day 1 till day 7 of gestation. Maternal body weights were also recorded daily. Rats were euthanized by diethyl ether inhalation on day 8 and the uteri removed and stained with 1% ammonium sulphide. The number of implantation sites was counted and data obtained were analysed using SPSS. There is a significant reduction in number of implantation sites i.e., treatment groups, positive and negative control and normal group are 0.83±0.401, 4.5±0.428, 8.67±0.333, 9.17±0.307 respectively. There is also a significant difference between
treatment and control group in maternal body weights. In addition, a high percentage (90%) of anti-implantation
activity was recorded in treatment groups. The small number of implantation sites and high percentage of anti-implantation activity suggests that Jatropha curcas crude oil have anti-fertility effects when fed to pregnant rats during early gestation. |
| first_indexed | 2025-11-15T09:03:39Z |
| format | Article |
| id | upm-29789 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:39Z |
| publishDate | 2013 |
| publisher | International Institute for Science, Technology & Education |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-297892017-10-30T04:05:06Z http://psasir.upm.edu.my/id/eprint/29789/ Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period Alwi, Nur Azira Sukardi, Sabrina Jatropha curcas is a species of flowering plants in the spurge family, Euphorbiaceae. The seeds contain 27-40% oil consisting of curcin and tetramethylpyrazine which are toxic and cause abortion, fetotoxicity and teratogenic effects if consume during pregnancy. Twenty four Sprague dawley rats at early gestation weighing about 200- 300g were randomized into four groups: Positive control group was orally administered with retinyl palmitate, negative control group with corn oil (vehicle), treatment group with 0.7 ml/kg body weight of the oil and the normal group was given distilled water. Females were paired overnight with male rats and presence of sperm in the vaginal smears indicated positive mating and considered pregnant day 1. Rats were dosed orally once daily from day 1 till day 7 of gestation. Maternal body weights were also recorded daily. Rats were euthanized by diethyl ether inhalation on day 8 and the uteri removed and stained with 1% ammonium sulphide. The number of implantation sites was counted and data obtained were analysed using SPSS. There is a significant reduction in number of implantation sites i.e., treatment groups, positive and negative control and normal group are 0.83±0.401, 4.5±0.428, 8.67±0.333, 9.17±0.307 respectively. There is also a significant difference between treatment and control group in maternal body weights. In addition, a high percentage (90%) of anti-implantation activity was recorded in treatment groups. The small number of implantation sites and high percentage of anti-implantation activity suggests that Jatropha curcas crude oil have anti-fertility effects when fed to pregnant rats during early gestation. International Institute for Science, Technology & Education 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29789/1/Anti%20implantation%20effects%20of%20Jatropha%20curcas%20crude%20oil%20when%20fed%20to%20pregnant%20Sprague%20dawley%20rats%20during%20the%20early%20gestation%20period.pdf Alwi, Nur Azira and Sukardi, Sabrina (2013) Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period. Advances in Life Science and Technology, 14. pp. 1-6. ISSN 2224-7181; ESSN: 2225-062X http://www.iiste.org/Journals/index.php/ALST/article/view/8607 |
| spellingShingle | Alwi, Nur Azira Sukardi, Sabrina Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period |
| title | Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period |
| title_full | Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period |
| title_fullStr | Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period |
| title_full_unstemmed | Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period |
| title_short | Anti implantation effects of Jatropha curcas crude oil when fed to pregnant Sprague dawley rats during the early gestation period |
| title_sort | anti implantation effects of jatropha curcas crude oil when fed to pregnant sprague dawley rats during the early gestation period |
| url | http://psasir.upm.edu.my/id/eprint/29789/ http://psasir.upm.edu.my/id/eprint/29789/ http://psasir.upm.edu.my/id/eprint/29789/1/Anti%20implantation%20effects%20of%20Jatropha%20curcas%20crude%20oil%20when%20fed%20to%20pregnant%20Sprague%20dawley%20rats%20during%20the%20early%20gestation%20period.pdf |