The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways
The Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), compounds are significantly cytotoxic to the HT-29 cancer cell line with1 being the most active. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29788/ http://psasir.upm.edu.my/id/eprint/29788/1/The%20in%EF%AC%82uence%20of%20R%20substituents%20in%20triphenylphosphinegold.pdf |
| _version_ | 1848846496926007296 |
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| author | Chien, Ing Yeo Kah, Kooi Ooi Md. Akim, Abdah Ang, Kok Pian Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R.T. |
| author_facet | Chien, Ing Yeo Kah, Kooi Ooi Md. Akim, Abdah Ang, Kok Pian Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R.T. |
| author_sort | Chien, Ing Yeo |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), compounds are significantly cytotoxic to the HT-29 cancer cell line with1 being the most active. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis is demonstrated and both the extrinsic and intrinsic pathways of apoptosis have been shown to occur. Compound1 activates the p73 gene, whereas each of2 and3 activates the p53 gene. An additional apoptotic mechanism is exhibited by2, that is, via the JNK/MAP pathway.
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| first_indexed | 2025-11-15T09:03:39Z |
| format | Article |
| id | upm-29788 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:39Z |
| publishDate | 2013 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-297882015-09-08T04:17:09Z http://psasir.upm.edu.my/id/eprint/29788/ The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways Chien, Ing Yeo Kah, Kooi Ooi Md. Akim, Abdah Ang, Kok Pian Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R.T. The Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), compounds are significantly cytotoxic to the HT-29 cancer cell line with1 being the most active. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis is demonstrated and both the extrinsic and intrinsic pathways of apoptosis have been shown to occur. Compound1 activates the p73 gene, whereas each of2 and3 activates the p53 gene. An additional apoptotic mechanism is exhibited by2, that is, via the JNK/MAP pathway. Elsevier 2013-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29788/1/The%20in%EF%AC%82uence%20of%20R%20substituents%20in%20triphenylphosphinegold.pdf Chien, Ing Yeo and Kah, Kooi Ooi and Md. Akim, Abdah and Ang, Kok Pian and Fairuz, Zainal Abidin and Abdul Halim, Siti Nadiah and Ng, Seik Weng and Seng, Hoi Ling and Tiekink, Edward R.T. (2013) The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways. Journal of Inorganic Biochemistry, 127. pp. 24-38. ISSN 0162-0134; ESSN: 1873-3344 10.1016/j.jinorgbio.2013.05.011 |
| spellingShingle | Chien, Ing Yeo Kah, Kooi Ooi Md. Akim, Abdah Ang, Kok Pian Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R.T. The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways |
| title | The influence of R substituents in triphenylphosphinegold(I)
carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways
|
| title_full | The influence of R substituents in triphenylphosphinegold(I)
carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways
|
| title_fullStr | The influence of R substituents in triphenylphosphinegold(I)
carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways
|
| title_full_unstemmed | The influence of R substituents in triphenylphosphinegold(I)
carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways
|
| title_short | The influence of R substituents in triphenylphosphinegold(I)
carbonimidothioates, Ph 3PAu[SC(OR) = NPh] (R = Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways
|
| title_sort | influence of r substituents in triphenylphosphinegold(i)
carbonimidothioates, ph 3pau[sc(or) = nph] (r = me, et and ipr), upon in vitro cytotoxicity against the ht-29 colon cancer cell line and upon apoptotic pathways |
| url | http://psasir.upm.edu.my/id/eprint/29788/ http://psasir.upm.edu.my/id/eprint/29788/ http://psasir.upm.edu.my/id/eprint/29788/1/The%20in%EF%AC%82uence%20of%20R%20substituents%20in%20triphenylphosphinegold.pdf |