QR Code

Safety profile of dextran-spermine gene delivery vector in mouse lungs

A nano-sized polymer, dextran-spermine (D-SPM), was shown to have the capacity to deliver gene to the lung of mouse via intranasal route. In this study, assessments on the safety profile of D-SPM were performed to complement the gene expression results. African green monkey kidney fibroblast (COS-7)...

Full description

Bibliographic Details
Main Authors:	Yeo, Wendy Wai Yeng, Hosseinkhani, Hossein, Abdul Rahman, Sabariah, Rosli, Rozita, Domb, Abraham J., Abdullah, Syahrilnizam
Format:	Article
Language:	English
Published:	American Scientific Publishers 2014
Online Access:	http://psasir.upm.edu.my/id/eprint/29784/ http://psasir.upm.edu.my/id/eprint/29784/1/Safety%20profile%20of%20dextran%20spermine%20gene%20delivery%20vector%20in%20mouse%20lungs.pdf

Similar Items

Gene transfer into the lung by nanoparticle dextran-spermine/plasmid DNA complexes.
by: Abdullah, Syahrilnizam, et al.
Published: (2010)

Optimal transfection conditions and the safety profiles of dextran spermine/plasmid DNA as potential gene transfer vector to mouse airway.
by: Rosli, Rozita, et al.
Published: (2010)

Dynamics of PEGylated-dextran-spermine nanoparticles for gene delivery to leukemic cells.
by: Amini, Razieh, et al.
Published: (2013)

In vitro intracellular trafficking of biodegradable nanoparticles dextran spermine in cancer cell lines.
by: Abedini, Fatemeh, et al.
Published: (2011)

Toxicity evaluation of dextran-spermine polycation as a tool for genetherapy in vitro.
by: Abedini, Fatemah, et al.
Published: (2010)

Effects of CXCR4 siRNA/dextran-spermine nanoparticles on CXCR4 expression and serum LDH levels in a mouse model of colorectal cancer metastasis to the liver.
by: Abedini, Fatemeh, et al.
Published: (2011)

Gene transfer into mouse airways using polycation based nanoparticle gene delivery system.
by: Wai Yeng, Wendy Yeo, et al.
Published: (2010)

In ovo vaccination against Newcastle disease virus using a DNA vaccine co-expressing the F and HN genes and dextran-spermin as a vehicle for DNA delivery
by: Firouzamandi, Masumeh, et al.
Published: (2013)

Preparation, characterization, and in ovo vaccination of dextran-spermine nanoparticle DNA vaccine coexpressing the fusion and hemagglutinin genes against Newcastle disease
by: Firouzamandi, Masoumeh, et al.
Published: (2016)

Preparation, characterization and in ovo vaccination of dextran-spermine nanopeprints dna vaccine coexpressing the fusion and hemagglutinin genes against newcastle disease
by: Firouzamandi, Masoumeh, et al.
Published: (2016)

Dually sensitive dextran-based micelles for methotrexate delivery
by: Blanco-Fernandez, B., et al.
Published: (2017)

Gene delivery potential of biofunctional carbonate apatite nanoparticles in lungs
by: Alhaji, Suleiman Yusuf, et al.
Published: (2014)

Production of lentiviral vector with polycistronic transcripts for reprogramming of mouse fibroblast cells
by: Al Abbar, Akram, et al.
Published: (2018)

PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma
by: Luo, Tian, et al.
Published: (2016)

Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets
by: Pandurangan, Ashok Kumar, et al.
Published: (2016)

Effects of CXCR4 Silencing by Sirna Engrafted Cotionized Dextran in Mouse Models of Colorectal Cancer and Liver Metastasis
by: Abedini, Fatemeh
Published: (2011)

Transgene expression from CpG-reduced lentiviral gene delivery vectors in vitro
by: Low, Poh Tee, et al.
Published: (2014)

The potential role of miRNA therapies in spinal muscle atrophy
by: Gandhi, Gayatri, et al.
Published: (2021)

Differentiation of skeletal muscle-derived stem cells into beta pancreatic lineage
by: Yeo, Wendy Wai Yeng
Published: (2015)

Gallic acid attenuates dextran sulfate sodium- induced experimental colitis in BALB/c mice
by: Pandurangan, Ashok Kumar, et al.
Published: (2015)

Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: possible mechanisms
by: Pandurangan, Ashok Kumar, et al.
Published: (2015)

Preliminary studies on the development of IgA-loaded chitosan-dextran sulphate nanoparticles as a potential nasal delivery system for protein antigens.
by: Sharma, Sameer, et al.
Published: (2013)

Advancements in reprogramming strategies for the generation of induced pluripotent stem cells.
by: Lai, Mei I., et al.
Published: (2011)

Induced pluripotent stem cells: history, properties and potential applications
by: Nordin, Norshariza, et al.
Published: (2011)

Spermidine/spermine N1-acetyltransferase gene expression in A549 cells treated with pomegranate juice
by: Nik Abdul Malek, Nik Nurasyikin, et al.
Published: (2015)

Investigating lung function gene GSTCD using gene targeting in human and mouse systems
by: Probert, Kelly
Published: (2016)

Rheological, spectral and thermal analyses of gellan/ dextran blends as gelatin substitutes
by: Ahmad, Nurul Hawa
Published: (2014)

Delivery of expression constructs of secreted frizzled-related protein 4 and its domains by chitosan–dextran sulfate nanoparticles enhances their expression and anti-cancer effects
by: Perumal, Vanathi, et al.
Published: (2017)

Generation of hemophilia A mouse induced pluripotent stem cells using polycistronic lentiviral vector in serum- and feeder-free culture conditions
by: M. Sakri, Rozita, et al.
Published: (2016)

Phosphorylcholine-based copolymer as synthetic vector for gene delivery
by: Lam, Jenny Ka-Wing
Published: (2006)

Hyperbranched polymers as non-viral vectors for gene delivery
by: Alazzo, Ali
Published: (2018)

Rice response to spermine foliar application and its association with aerial imagery monitoring under water stress conditions
by: Nur Zahirah Abd. Jalil,, et al.
Published: (2024)

Regulation of sucrose synthase and its association with grain filling in spermine treated rice plant under water deficit
by: Berahim, Zulkarami, et al.
Published: (2019)

Rice response to spermine foliar application and its association with aerial imagery monitoring under water stress conditions
by: Abd. Jalil, Nur Zahirah, et al.
Published: (2024)

Spermine mediated improvements on stomatal features, growth, grain filling and yield of rice under differing water availability
by: Berahim, Zulkarami, et al.
Published: (2021)

Potential of novel dextran oligosaccharides as prebiotics for obesity management through in vitro experimentation
by: Sarbini, Shahrul Razid, et al.
Published: (2014)

Study on Liposomes Integrity and Delivery of siRNA to Lung Cancer
by: Aljasser, Abdullah
Published: (2024)

Treatment of lung cancer using nanoparticle drug delivery systems
by: Chandolu, V., et al.
Published: (2013)

Improving drug delivery to the lungs as a function of excipient choice
by: Olubi, Rebecca
Published: (2024)

Improving the antifouling property of polyethersulfone ultrafiltration membrane by incorporation of dextran grafted halloysite nanotubes
by: Yu, H., et al.
Published: (2014)