Recent advances in diagnosis of acute myeloid leukaemia : a review.
Acute Myeloid Leukaemia is one of the commonest blood cancer in Malaysia. Recent advancements in molecular genetics have led to better understanding of AML pathogenesis which is crucial for patient stratification and therapeutic options. The advent of next generation sequencing (NGS) is now the vogu...
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| Format: | Article |
| Language: | English |
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Sonhira Publication
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29761/ http://psasir.upm.edu.my/id/eprint/29761/1/Recent%20advances%20in%20diagnosis%20of%20acute%20myeloid%20leukaemia.pdf |
| _version_ | 1848846489253576704 |
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| author | Ambayya, Angeli Seman, Zainina Md Noor, Sabariah |
| author_facet | Ambayya, Angeli Seman, Zainina Md Noor, Sabariah |
| author_sort | Ambayya, Angeli |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Acute Myeloid Leukaemia is one of the commonest blood cancer in Malaysia. Recent advancements in molecular genetics have led to better understanding of AML pathogenesis which is crucial for patient stratification and therapeutic options. The advent of next generation sequencing (NGS) is now the vogue to interrogate acute myeloid leukaemia (AML) genome at single base pair resolution. In this review, we will discuss current approaches in the diagnosis of AML and the role of NGS in elucidation of genomic aberrations. Although NGS is anticipated to impact the new era of AML diagnosis, there are challenges in understanding mutations found in an AML genome and how this technology will be implemented in a diagnostic setting. NGS will pave the way for perso
nalized medicine approach, with the hope of better response to tailored treatment regimen. |
| first_indexed | 2025-11-15T09:03:31Z |
| format | Article |
| id | upm-29761 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:31Z |
| publishDate | 2013 |
| publisher | Sonhira Publication |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-297612015-09-02T04:12:01Z http://psasir.upm.edu.my/id/eprint/29761/ Recent advances in diagnosis of acute myeloid leukaemia : a review. Ambayya, Angeli Seman, Zainina Md Noor, Sabariah Acute Myeloid Leukaemia is one of the commonest blood cancer in Malaysia. Recent advancements in molecular genetics have led to better understanding of AML pathogenesis which is crucial for patient stratification and therapeutic options. The advent of next generation sequencing (NGS) is now the vogue to interrogate acute myeloid leukaemia (AML) genome at single base pair resolution. In this review, we will discuss current approaches in the diagnosis of AML and the role of NGS in elucidation of genomic aberrations. Although NGS is anticipated to impact the new era of AML diagnosis, there are challenges in understanding mutations found in an AML genome and how this technology will be implemented in a diagnostic setting. NGS will pave the way for perso nalized medicine approach, with the hope of better response to tailored treatment regimen. Sonhira Publication 2013-12 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29761/1/Recent%20advances%20in%20diagnosis%20of%20acute%20myeloid%20leukaemia.pdf Ambayya, Angeli and Seman, Zainina and Md Noor, Sabariah (2013) Recent advances in diagnosis of acute myeloid leukaemia : a review. Asian Journal of Multidiciplinary Study, 1 (5). pp. 145-150. ISSN 2348-7186; ESSN: 2321-8819 |
| spellingShingle | Ambayya, Angeli Seman, Zainina Md Noor, Sabariah Recent advances in diagnosis of acute myeloid leukaemia : a review. |
| title | Recent advances in diagnosis of acute myeloid leukaemia : a review. |
| title_full | Recent advances in diagnosis of acute myeloid leukaemia : a review. |
| title_fullStr | Recent advances in diagnosis of acute myeloid leukaemia : a review. |
| title_full_unstemmed | Recent advances in diagnosis of acute myeloid leukaemia : a review. |
| title_short | Recent advances in diagnosis of acute myeloid leukaemia : a review. |
| title_sort | recent advances in diagnosis of acute myeloid leukaemia : a review. |
| url | http://psasir.upm.edu.my/id/eprint/29761/ http://psasir.upm.edu.my/id/eprint/29761/1/Recent%20advances%20in%20diagnosis%20of%20acute%20myeloid%20leukaemia.pdf |