Antibody and immune memory persistence post infant hepatitis B vaccination
OBJECTIVES: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia. METHODS: A total of 402 serum samples obtained from volunteer undergraduate students were scr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29713/ http://psasir.upm.edu.my/id/eprint/29713/1/29713.pdf |
| _version_ | 1848846475544494080 |
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| author | Shuaibu, Hudu Abdullahi A. Malik, Yasmin Mohd Taib, Niazlin Mohammed Harmal, Nabil Saad Adnan, Ariza Alshrari, Ahmed Subeh D. Sekawi, Zamberi |
| author_facet | Shuaibu, Hudu Abdullahi A. Malik, Yasmin Mohd Taib, Niazlin Mohammed Harmal, Nabil Saad Adnan, Ariza Alshrari, Ahmed Subeh D. Sekawi, Zamberi |
| author_sort | Shuaibu, Hudu Abdullahi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | OBJECTIVES: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia.
METHODS: A total of 402 serum samples obtained from volunteer undergraduate students were screened for the presence of hepatitis B surface antibodies using qualitative ELISA.
RESULTS: Results showed that 62.7% of volunteers had protective anti-hepatitis B surface antigens (≥10 IU/L), of whom 67.9% received three doses of the vaccine. The estimated post-vaccination immunity was found to be at least 20 years, indicating persistent immunity against hepatitis B and a significant association (P < 0.05) with duration of vaccination. Anamnestic response 1 month post-hepatitis B booster was 94.0% and highly significant (P < 0.01). Isolated antihepatitis B core antigen (anti-HBc) prevalence was found to be 5.0%, all having had a positive anamnestic response.
CONCLUSION: Immunity after primary vaccination with hepatitis B recombinant vaccine persists for at least 20 years post-vaccination, with significant association with the number of vaccinations. Furthermore, the presence of anamnestic response to booster vaccine indicates long-lasting immunity despite decreasing antibody levels; therefore, the need for hepatitis B vaccine boosters may not be of significant benefit after complete infant vaccination. |
| first_indexed | 2025-11-15T09:03:18Z |
| format | Article |
| id | upm-29713 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:18Z |
| publishDate | 2013 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-297132017-08-09T04:29:23Z http://psasir.upm.edu.my/id/eprint/29713/ Antibody and immune memory persistence post infant hepatitis B vaccination Shuaibu, Hudu Abdullahi A. Malik, Yasmin Mohd Taib, Niazlin Mohammed Harmal, Nabil Saad Adnan, Ariza Alshrari, Ahmed Subeh D. Sekawi, Zamberi OBJECTIVES: This study aimed to evaluate the level of hepatitis B immunity among undergraduate students 23 years after commencement of the nationwide hepatitis B childhood immunization program in Malaysia. METHODS: A total of 402 serum samples obtained from volunteer undergraduate students were screened for the presence of hepatitis B surface antibodies using qualitative ELISA. RESULTS: Results showed that 62.7% of volunteers had protective anti-hepatitis B surface antigens (≥10 IU/L), of whom 67.9% received three doses of the vaccine. The estimated post-vaccination immunity was found to be at least 20 years, indicating persistent immunity against hepatitis B and a significant association (P < 0.05) with duration of vaccination. Anamnestic response 1 month post-hepatitis B booster was 94.0% and highly significant (P < 0.01). Isolated antihepatitis B core antigen (anti-HBc) prevalence was found to be 5.0%, all having had a positive anamnestic response. CONCLUSION: Immunity after primary vaccination with hepatitis B recombinant vaccine persists for at least 20 years post-vaccination, with significant association with the number of vaccinations. Furthermore, the presence of anamnestic response to booster vaccine indicates long-lasting immunity despite decreasing antibody levels; therefore, the need for hepatitis B vaccine boosters may not be of significant benefit after complete infant vaccination. Dove Medical Press 2013-09-26 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29713/1/29713.pdf Shuaibu, Hudu Abdullahi and A. Malik, Yasmin and Mohd Taib, Niazlin and Mohammed Harmal, Nabil Saad and Adnan, Ariza and Alshrari, Ahmed Subeh D. and Sekawi, Zamberi (2013) Antibody and immune memory persistence post infant hepatitis B vaccination. Patient Preference and Adherence, 7. pp. 981-986. ISSN 1177-889X https://www.dovepress.com/antibody-and-immune-memory-persistence-post-infant-hepatitis-b-vaccina-peer-reviewed-article-PPA 10.2147/PPA.S49776 |
| spellingShingle | Shuaibu, Hudu Abdullahi A. Malik, Yasmin Mohd Taib, Niazlin Mohammed Harmal, Nabil Saad Adnan, Ariza Alshrari, Ahmed Subeh D. Sekawi, Zamberi Antibody and immune memory persistence post infant hepatitis B vaccination |
| title | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_full | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_fullStr | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_full_unstemmed | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_short | Antibody and immune memory persistence post infant hepatitis B vaccination |
| title_sort | antibody and immune memory persistence post infant hepatitis b vaccination |
| url | http://psasir.upm.edu.my/id/eprint/29713/ http://psasir.upm.edu.my/id/eprint/29713/ http://psasir.upm.edu.my/id/eprint/29713/ http://psasir.upm.edu.my/id/eprint/29713/1/29713.pdf |