Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents
Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work. There are lack of information regarding to the effect of Mitragyna speciosa on cognitive and behavioural performa...
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| Format: | Article |
| Language: | English |
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David Publishing
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29705/ http://psasir.upm.edu.my/id/eprint/29705/1/Sedative%2C%20cognitive%20impairment%20and%20anxiolytic%20effects%20of%20acute%20Mitragyna%20speciosa%20in%20rodents.pdf |
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| author | Mohd Moklas, Mohamad Aris Suliman, Noor Azuin Mat Taib, Che Norma Baharuldin, Mohamad Taufik Hidayat Fakurazi, Sharida Zakaria, Fatin Nadzirah Muhamamd Yusof, Muhammad Khairulasraf Adzhar, Muhammad Farhan Md Rasul, Mohd Saifuddin Md Akim, Abdah Amom, Zulkhairi |
| author_facet | Mohd Moklas, Mohamad Aris Suliman, Noor Azuin Mat Taib, Che Norma Baharuldin, Mohamad Taufik Hidayat Fakurazi, Sharida Zakaria, Fatin Nadzirah Muhamamd Yusof, Muhammad Khairulasraf Adzhar, Muhammad Farhan Md Rasul, Mohd Saifuddin Md Akim, Abdah Amom, Zulkhairi |
| author_sort | Mohd Moklas, Mohamad Aris |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work. There are lack of information regarding to the effect of Mitragyna speciosa on cognitive and behavioural performances. Therefore the project was conducted to observe the effect of Mitragyna speciosa on cognitive behavior of rats and mice. Mitragyna speciosa in methanol extract form and aqueous extract form with same dosage distributions were used; 10 mg/kg, 30 mg/kg, and 100 mg/kg. Four tests were conducted to observe the behavioural changes of the animal namely locomotor, cognitive performances, anxiety and rotarod performance. Results showed that all dosage of treatment reduced locomotor and impaired cognitive performance significantly. Study showed that Mitragyna speciosa induce sedative effect in dose dependant manner. Interestingly, Mitragyna speciosa increased the time spent in open arm of plus maze indicating low anxiety level of the rodent. As conclusion, Mitragyna speciosa caused sedative effect, impairment in working memory, and possess anxiolytic properties. |
| first_indexed | 2025-11-15T09:03:16Z |
| format | Article |
| id | upm-29705 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:16Z |
| publishDate | 2013 |
| publisher | David Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-297052015-10-07T08:30:01Z http://psasir.upm.edu.my/id/eprint/29705/ Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents Mohd Moklas, Mohamad Aris Suliman, Noor Azuin Mat Taib, Che Norma Baharuldin, Mohamad Taufik Hidayat Fakurazi, Sharida Zakaria, Fatin Nadzirah Muhamamd Yusof, Muhammad Khairulasraf Adzhar, Muhammad Farhan Md Rasul, Mohd Saifuddin Md Akim, Abdah Amom, Zulkhairi Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work. There are lack of information regarding to the effect of Mitragyna speciosa on cognitive and behavioural performances. Therefore the project was conducted to observe the effect of Mitragyna speciosa on cognitive behavior of rats and mice. Mitragyna speciosa in methanol extract form and aqueous extract form with same dosage distributions were used; 10 mg/kg, 30 mg/kg, and 100 mg/kg. Four tests were conducted to observe the behavioural changes of the animal namely locomotor, cognitive performances, anxiety and rotarod performance. Results showed that all dosage of treatment reduced locomotor and impaired cognitive performance significantly. Study showed that Mitragyna speciosa induce sedative effect in dose dependant manner. Interestingly, Mitragyna speciosa increased the time spent in open arm of plus maze indicating low anxiety level of the rodent. As conclusion, Mitragyna speciosa caused sedative effect, impairment in working memory, and possess anxiolytic properties. David Publishing 2013-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29705/1/Sedative%2C%20cognitive%20impairment%20and%20anxiolytic%20effects%20of%20acute%20Mitragyna%20speciosa%20in%20rodents.pdf Mohd Moklas, Mohamad Aris and Suliman, Noor Azuin and Mat Taib, Che Norma and Baharuldin, Mohamad Taufik Hidayat and Fakurazi, Sharida and Zakaria, Fatin Nadzirah and Muhamamd Yusof, Muhammad Khairulasraf and Adzhar, Muhammad Farhan and Md Rasul, Mohd Saifuddin and Md Akim, Abdah and Amom, Zulkhairi (2013) Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents. Journal of US-China Medical Science, 10 (1-2). pp. 37-44. ISSN 1548-6648; ESSN: 1930-2088 http://davidpublishing.com/show.html?13858 |
| spellingShingle | Mohd Moklas, Mohamad Aris Suliman, Noor Azuin Mat Taib, Che Norma Baharuldin, Mohamad Taufik Hidayat Fakurazi, Sharida Zakaria, Fatin Nadzirah Muhamamd Yusof, Muhammad Khairulasraf Adzhar, Muhammad Farhan Md Rasul, Mohd Saifuddin Md Akim, Abdah Amom, Zulkhairi Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents |
| title | Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents |
| title_full | Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents |
| title_fullStr | Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents |
| title_full_unstemmed | Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents |
| title_short | Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents |
| title_sort | sedative, cognitive impairment and anxiolytic effects of acute mitragyna speciosa in rodents |
| url | http://psasir.upm.edu.my/id/eprint/29705/ http://psasir.upm.edu.my/id/eprint/29705/ http://psasir.upm.edu.my/id/eprint/29705/1/Sedative%2C%20cognitive%20impairment%20and%20anxiolytic%20effects%20of%20acute%20Mitragyna%20speciosa%20in%20rodents.pdf |