Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice
Interleukin-27 (IL-27) has a pleiotropic role either as a pro-inflammatory or anti-inflammatory cytokine in inflammatory related diseases. The role and involvement of IL-27 during malaria was investigated and the effects of modulating its release on the production of major inflammatory cytokines and...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Parasitology and Tropical Medicine
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29692/ http://psasir.upm.edu.my/id/eprint/29692/1/Interleukin.pdf |
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| author | Fazalul Rahiman, Siti Sarah Basir, Rusliza Talib, Herni Tie, Tung Hing Chuah, Yaw Kuang Jabbarzare, Marzieh Chong, Wing Chui Mohd Yusof, Mohd Afiq Asyran Nordin, Norshariza Yam, Mun Fei Abdullah, Wan Omar Abdul Majid, Roslaini |
| author_facet | Fazalul Rahiman, Siti Sarah Basir, Rusliza Talib, Herni Tie, Tung Hing Chuah, Yaw Kuang Jabbarzare, Marzieh Chong, Wing Chui Mohd Yusof, Mohd Afiq Asyran Nordin, Norshariza Yam, Mun Fei Abdullah, Wan Omar Abdul Majid, Roslaini |
| author_sort | Fazalul Rahiman, Siti Sarah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Interleukin-27 (IL-27) has a pleiotropic role either as a pro-inflammatory or anti-inflammatory cytokine in inflammatory related diseases. The role and involvement of IL-27 during malaria was investigated and the effects of modulating its release on the production of major inflammatory cytokines and the histopathological consequences in major affected organs during the infection were evaluated. Results showed that IL-27 concentration was significantly elevated throughout the infection but no positive correlation with the parasitaemia development observed. Augmentation of IL-27 significantly elevated the release of anti-inflammatory cytokine, IL-10 whereas antagonising and neutralising IL-27 produced the opposite. A significant elevation of pro-inflammatory cytokines (IFN-γ and IL-6) was also observed, both during augmentation and inhibition of IL-27. Thus, it is suggested that IL-27 exerts an anti-inflammatory activity in the Th1 type response by signalling the production of IL-10 during malaria. Histopathological examination showed sequestration of PRBC in the microvasculature of major organs in malarial mice. Other significant histopathological changes include hyperplasia and hypertrophy of the Kupffer cells in the liver, hyaline membrane formation in lung tissue, enlargement of the white and red pulp followed by the disappearance of germinal centre of the spleen, and tubular vacuolation of the kidney tissues. In conclusion, it is suggested that IL-27 may possibly acts as an anti-inflammatory cytokine during the infection. Modulation of its release produced a positive impact on inflammatory cytokine production during the infection, suggesting its potential in malaria immunotherapy, in which the host may benefit from its inhibition. |
| first_indexed | 2025-11-15T09:03:12Z |
| format | Article |
| id | upm-29692 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:12Z |
| publishDate | 2013 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-296922015-09-15T04:09:44Z http://psasir.upm.edu.my/id/eprint/29692/ Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice Fazalul Rahiman, Siti Sarah Basir, Rusliza Talib, Herni Tie, Tung Hing Chuah, Yaw Kuang Jabbarzare, Marzieh Chong, Wing Chui Mohd Yusof, Mohd Afiq Asyran Nordin, Norshariza Yam, Mun Fei Abdullah, Wan Omar Abdul Majid, Roslaini Interleukin-27 (IL-27) has a pleiotropic role either as a pro-inflammatory or anti-inflammatory cytokine in inflammatory related diseases. The role and involvement of IL-27 during malaria was investigated and the effects of modulating its release on the production of major inflammatory cytokines and the histopathological consequences in major affected organs during the infection were evaluated. Results showed that IL-27 concentration was significantly elevated throughout the infection but no positive correlation with the parasitaemia development observed. Augmentation of IL-27 significantly elevated the release of anti-inflammatory cytokine, IL-10 whereas antagonising and neutralising IL-27 produced the opposite. A significant elevation of pro-inflammatory cytokines (IFN-γ and IL-6) was also observed, both during augmentation and inhibition of IL-27. Thus, it is suggested that IL-27 exerts an anti-inflammatory activity in the Th1 type response by signalling the production of IL-10 during malaria. Histopathological examination showed sequestration of PRBC in the microvasculature of major organs in malarial mice. Other significant histopathological changes include hyperplasia and hypertrophy of the Kupffer cells in the liver, hyaline membrane formation in lung tissue, enlargement of the white and red pulp followed by the disappearance of germinal centre of the spleen, and tubular vacuolation of the kidney tissues. In conclusion, it is suggested that IL-27 may possibly acts as an anti-inflammatory cytokine during the infection. Modulation of its release produced a positive impact on inflammatory cytokine production during the infection, suggesting its potential in malaria immunotherapy, in which the host may benefit from its inhibition. Malaysian Society of Parasitology and Tropical Medicine 2013-12 Article NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29692/1/Interleukin.pdf Fazalul Rahiman, Siti Sarah and Basir, Rusliza and Talib, Herni and Tie, Tung Hing and Chuah, Yaw Kuang and Jabbarzare, Marzieh and Chong, Wing Chui and Mohd Yusof, Mohd Afiq Asyran and Nordin, Norshariza and Yam, Mun Fei and Abdullah, Wan Omar and Abdul Majid, Roslaini (2013) Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice. Tropical Biomedicine, 30 (4). pp. 663-680. ISSN 0127-5720 http://www.msptm.org/files/663_-_680_Fazalul_Rahiman_SS.pdf |
| spellingShingle | Fazalul Rahiman, Siti Sarah Basir, Rusliza Talib, Herni Tie, Tung Hing Chuah, Yaw Kuang Jabbarzare, Marzieh Chong, Wing Chui Mohd Yusof, Mohd Afiq Asyran Nordin, Norshariza Yam, Mun Fei Abdullah, Wan Omar Abdul Majid, Roslaini Interleukin-27 exhibited anti-inflammatory activity during Plasmodium berghei infection in mice |
| title | Interleukin-27 exhibited anti-inflammatory activity during
Plasmodium berghei infection in mice |
| title_full | Interleukin-27 exhibited anti-inflammatory activity during
Plasmodium berghei infection in mice |
| title_fullStr | Interleukin-27 exhibited anti-inflammatory activity during
Plasmodium berghei infection in mice |
| title_full_unstemmed | Interleukin-27 exhibited anti-inflammatory activity during
Plasmodium berghei infection in mice |
| title_short | Interleukin-27 exhibited anti-inflammatory activity during
Plasmodium berghei infection in mice |
| title_sort | interleukin-27 exhibited anti-inflammatory activity during
plasmodium berghei infection in mice |
| url | http://psasir.upm.edu.my/id/eprint/29692/ http://psasir.upm.edu.my/id/eprint/29692/ http://psasir.upm.edu.my/id/eprint/29692/1/Interleukin.pdf |