Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients

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Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients

BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine catabolic enzyme involved in the initial and rate-limiting step of the catabolic pathway of toxic metabolites of 5-fluorouracil (5-FU). Several studies have reported that deficiency of DPD and polymorphisms of its gene are related to...

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Main Authors:	Teh, Lay Kek, Hamzah, Sharina, Hashim, Hazwanie, Bannur, Zakaria, Zakaria, Zainul Amiruddin, Hasbullani, Zakaria, Kwong, John Siew Shia, Fijeraid, Henry, Md Nor, Azmid, Mohd Zailani, Ramasamy, Prabu, Ngow, Harris, Sood, Suneet, Salleh, Mohd Zaki
Format:	Article
Language:	English
Published:	Lippincott Williams & Wilkins 2013
Online Access:	http://psasir.upm.edu.my/id/eprint/29679/ http://psasir.upm.edu.my/id/eprint/29679/1/Potential%20of%20dihydropyrimidine%20dehydrogenase%20genotypes%20in%20personalizing%205.pdf

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