Molecular pathways governing development of vascular endothelial cells from ES/iPS cells
Assembly of complex vascular networks occurs in numerous biological systems through morphogenetic processes such as vasculogenesis, angiogenesis and vascular remodeling. Pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any cell type,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/29663/ http://psasir.upm.edu.my/id/eprint/29663/1/Molecular%20pathways%20governing%20development%20of%20vascular%20endothelial%20cells%20from%20ES.pdf |
| _version_ | 1848846461480992768 |
|---|---|
| author | Tan, Keai Sinn Tamura, Kiyomi Lai, Mei I. Veerakumarasivam, Abhimanyu Nakanishi, Yoichi Ogawa, Minetaro Sugiyama, Daisuke |
| author_facet | Tan, Keai Sinn Tamura, Kiyomi Lai, Mei I. Veerakumarasivam, Abhimanyu Nakanishi, Yoichi Ogawa, Minetaro Sugiyama, Daisuke |
| author_sort | Tan, Keai Sinn |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Assembly of complex vascular networks occurs in numerous biological systems through morphogenetic processes such as vasculogenesis, angiogenesis and vascular remodeling. Pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any cell type, including endothelial cells (ECs), and have been extensively used as in vitro models to analyze molecular mechanisms underlying EC generation and differentiation. The emergence of these promising new approaches suggests that ECs could be used in clinical therapy. Much evidence suggests that ES/iPS cell differentiation into ECs in vitro mimics the in vivo vascular morphogenic process. Through sequential steps of maturation, ECs derived from ES/iPS cells can be further differentiated into arterial, venous, capillary and lymphatic ECs, as well as smooth muscle cells. Here, we review EC development from ES/iPS cells with special attention to molecular pathways functioning in EC specification. |
| first_indexed | 2025-11-15T09:03:05Z |
| format | Article |
| id | upm-29663 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:05Z |
| publishDate | 2013 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-296632015-12-29T04:42:56Z http://psasir.upm.edu.my/id/eprint/29663/ Molecular pathways governing development of vascular endothelial cells from ES/iPS cells Tan, Keai Sinn Tamura, Kiyomi Lai, Mei I. Veerakumarasivam, Abhimanyu Nakanishi, Yoichi Ogawa, Minetaro Sugiyama, Daisuke Assembly of complex vascular networks occurs in numerous biological systems through morphogenetic processes such as vasculogenesis, angiogenesis and vascular remodeling. Pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any cell type, including endothelial cells (ECs), and have been extensively used as in vitro models to analyze molecular mechanisms underlying EC generation and differentiation. The emergence of these promising new approaches suggests that ECs could be used in clinical therapy. Much evidence suggests that ES/iPS cell differentiation into ECs in vitro mimics the in vivo vascular morphogenic process. Through sequential steps of maturation, ECs derived from ES/iPS cells can be further differentiated into arterial, venous, capillary and lymphatic ECs, as well as smooth muscle cells. Here, we review EC development from ES/iPS cells with special attention to molecular pathways functioning in EC specification. Springer 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29663/1/Molecular%20pathways%20governing%20development%20of%20vascular%20endothelial%20cells%20from%20ES.pdf Tan, Keai Sinn and Tamura, Kiyomi and Lai, Mei I. and Veerakumarasivam, Abhimanyu and Nakanishi, Yoichi and Ogawa, Minetaro and Sugiyama, Daisuke (2013) Molecular pathways governing development of vascular endothelial cells from ES/iPS cells. Stem Cell Reviews and Reports, 9 (5). pp. 586-598. ISSN 1550-8943; ESSN: 1558-6804 10.1007/s12015-013-9450-7 |
| spellingShingle | Tan, Keai Sinn Tamura, Kiyomi Lai, Mei I. Veerakumarasivam, Abhimanyu Nakanishi, Yoichi Ogawa, Minetaro Sugiyama, Daisuke Molecular pathways governing development of vascular endothelial cells from ES/iPS cells |
| title | Molecular pathways governing development of vascular endothelial cells from ES/iPS cells |
| title_full | Molecular pathways governing development of vascular endothelial cells from ES/iPS cells |
| title_fullStr | Molecular pathways governing development of vascular endothelial cells from ES/iPS cells |
| title_full_unstemmed | Molecular pathways governing development of vascular endothelial cells from ES/iPS cells |
| title_short | Molecular pathways governing development of vascular endothelial cells from ES/iPS cells |
| title_sort | molecular pathways governing development of vascular endothelial cells from es/ips cells |
| url | http://psasir.upm.edu.my/id/eprint/29663/ http://psasir.upm.edu.my/id/eprint/29663/ http://psasir.upm.edu.my/id/eprint/29663/1/Molecular%20pathways%20governing%20development%20of%20vascular%20endothelial%20cells%20from%20ES.pdf |