Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment
Palm kernel oil esters nanoemulsion-loaded with chloramphenicol was optimized using response surface methodology (RSM), a multivariate statistical technique. Effect of independent variables (oil amount, lecithin amount and glycerol amount) toward response variables (particle size, polydispersity ind...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29660/ http://psasir.upm.edu.my/id/eprint/29660/1/Formulation%20optimization%20of%20palm%20kernel%20oil%20esters%20nanoemulsion.pdf |
| _version_ | 1848846460676734976 |
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| author | Musa, Siti Hajar Basri, Mahiran Masoumi, Hamid Reza Fard Karjiban, Roghayeh Abedi Abd Malek, Emilia Basri, Hamidon Shamsuddin, Ahmad Fuad |
| author_facet | Musa, Siti Hajar Basri, Mahiran Masoumi, Hamid Reza Fard Karjiban, Roghayeh Abedi Abd Malek, Emilia Basri, Hamidon Shamsuddin, Ahmad Fuad |
| author_sort | Musa, Siti Hajar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Palm kernel oil esters nanoemulsion-loaded with chloramphenicol was optimized using response surface methodology (RSM), a multivariate statistical technique. Effect of independent variables (oil amount, lecithin amount and glycerol amount) toward response variables (particle size, polydispersity index, zeta potential and osmolality) were studied using central composite design (CCD). RSM analysis showed that the experimental data could be fitted into a second-order polynomial model. Chloramphenicol-loaded nanoemulsion was formulated by using high pressure homogenizer. The optimized chloramphenicol-loaded nanoemulsion response values for particle size, PDI, zeta potential and osmolality were 95.33nm, 0.238, -36.91mV, and 200mOsm/kg, respectively. The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM. The results showed that the optimized compositions have the potential to be used as a parenteral emulsion to cross blood-brain barrier (BBB) for meningitis treatment. |
| first_indexed | 2025-11-15T09:03:04Z |
| format | Article |
| id | upm-29660 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:03:04Z |
| publishDate | 2013 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-296602015-10-07T01:15:03Z http://psasir.upm.edu.my/id/eprint/29660/ Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment Musa, Siti Hajar Basri, Mahiran Masoumi, Hamid Reza Fard Karjiban, Roghayeh Abedi Abd Malek, Emilia Basri, Hamidon Shamsuddin, Ahmad Fuad Palm kernel oil esters nanoemulsion-loaded with chloramphenicol was optimized using response surface methodology (RSM), a multivariate statistical technique. Effect of independent variables (oil amount, lecithin amount and glycerol amount) toward response variables (particle size, polydispersity index, zeta potential and osmolality) were studied using central composite design (CCD). RSM analysis showed that the experimental data could be fitted into a second-order polynomial model. Chloramphenicol-loaded nanoemulsion was formulated by using high pressure homogenizer. The optimized chloramphenicol-loaded nanoemulsion response values for particle size, PDI, zeta potential and osmolality were 95.33nm, 0.238, -36.91mV, and 200mOsm/kg, respectively. The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM. The results showed that the optimized compositions have the potential to be used as a parenteral emulsion to cross blood-brain barrier (BBB) for meningitis treatment. Elsevier BV 2013-12-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29660/1/Formulation%20optimization%20of%20palm%20kernel%20oil%20esters%20nanoemulsion.pdf Musa, Siti Hajar and Basri, Mahiran and Masoumi, Hamid Reza Fard and Karjiban, Roghayeh Abedi and Abd Malek, Emilia and Basri, Hamidon and Shamsuddin, Ahmad Fuad (2013) Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment. Colloids and Surfaces B: Biointerfaces, 112. pp. 113-119. ISSN 0927-7765; ESSN: 1873-4367 10.1016/j.colsurfb.2013.07.043. |
| spellingShingle | Musa, Siti Hajar Basri, Mahiran Masoumi, Hamid Reza Fard Karjiban, Roghayeh Abedi Abd Malek, Emilia Basri, Hamidon Shamsuddin, Ahmad Fuad Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment |
| title | Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment |
| title_full | Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment |
| title_fullStr | Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment |
| title_full_unstemmed | Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment |
| title_short | Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment |
| title_sort | formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment |
| url | http://psasir.upm.edu.my/id/eprint/29660/ http://psasir.upm.edu.my/id/eprint/29660/ http://psasir.upm.edu.my/id/eprint/29660/1/Formulation%20optimization%20of%20palm%20kernel%20oil%20esters%20nanoemulsion.pdf |