Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model
Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva was able to reverse the ovariectomy-induced changes in biochemical markers, bone calcium,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29630/ http://psasir.upm.edu.my/id/eprint/29630/1/Labisia%20pumila%20regulates%20bone.pdf |
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| author | Ahmad Ariffin, Siti Noor Fathilah Mohamed, Norazlina Muhammad, Norliza Mohamed, Isa Naina Soelaiman, Ima Nirwana Shuid, Ahmad Nazrun |
| author_facet | Ahmad Ariffin, Siti Noor Fathilah Mohamed, Norazlina Muhammad, Norliza Mohamed, Isa Naina Soelaiman, Ima Nirwana Shuid, Ahmad Nazrun |
| author_sort | Ahmad Ariffin, Siti Noor Fathilah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva was able to reverse the ovariectomy-induced changes in biochemical markers, bone calcium, bone histomorphometric parameters and biomechanical strength. The mechanism behind these protective effects is unclear but LPva may have regulated factors that regulate bone remodeling. The aim of this study is to determine the bone-protective mechanism of LPva by measuring the expressions of several factors involved in bone formative and resorptive activities namely Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL), Macrophage-Colony Stimulating Factor (MCSF) and Bone Morphogenetic Protein-2 (BMP-2). |
| first_indexed | 2025-11-15T09:02:56Z |
| format | Article |
| id | upm-29630 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:02:56Z |
| publishDate | 2013 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-296302015-09-04T08:12:15Z http://psasir.upm.edu.my/id/eprint/29630/ Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model Ahmad Ariffin, Siti Noor Fathilah Mohamed, Norazlina Muhammad, Norliza Mohamed, Isa Naina Soelaiman, Ima Nirwana Shuid, Ahmad Nazrun Labisia Pumila var. alata (LPva) has shown potential as an alternative to estrogen replacement therapy (ERT) in prevention of estrogen-deficient osteoporosis. In earlier studies using postmenopausal model, LPva was able to reverse the ovariectomy-induced changes in biochemical markers, bone calcium, bone histomorphometric parameters and biomechanical strength. The mechanism behind these protective effects is unclear but LPva may have regulated factors that regulate bone remodeling. The aim of this study is to determine the bone-protective mechanism of LPva by measuring the expressions of several factors involved in bone formative and resorptive activities namely Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL), Macrophage-Colony Stimulating Factor (MCSF) and Bone Morphogenetic Protein-2 (BMP-2). BioMed Central 2013-09-05 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29630/1/Labisia%20pumila%20regulates%20bone.pdf Ahmad Ariffin, Siti Noor Fathilah and Mohamed, Norazlina and Muhammad, Norliza and Mohamed, Isa Naina and Soelaiman, Ima Nirwana and Shuid, Ahmad Nazrun (2013) Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model. BMC Complementary and Alternative Medicine, 13. art. no. 217. pp. 1-7. ISSN 1472-6882 http://www.biomedcentral.com/1472-6882/13/217 10.1186/1472-6882-13-217 |
| spellingShingle | Ahmad Ariffin, Siti Noor Fathilah Mohamed, Norazlina Muhammad, Norliza Mohamed, Isa Naina Soelaiman, Ima Nirwana Shuid, Ahmad Nazrun Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model |
| title | Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model |
| title_full | Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model |
| title_fullStr | Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model |
| title_full_unstemmed | Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model |
| title_short | Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model |
| title_sort | labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model |
| url | http://psasir.upm.edu.my/id/eprint/29630/ http://psasir.upm.edu.my/id/eprint/29630/ http://psasir.upm.edu.my/id/eprint/29630/ http://psasir.upm.edu.my/id/eprint/29630/1/Labisia%20pumila%20regulates%20bone.pdf |