Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI
AIM: To investigate the diagnostic accuracy of single-voxel proton magnetic resonance spectroscopy (SV (1)H MRS) by quantifying total choline-containing compounds (tCho) in differentiating malignant from benign lesions, and subsequently, to analyse the relationship of tCho levels in malignant breast...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/29597/ http://psasir.upm.edu.my/id/eprint/29597/1/Improved%20diagnostic%20accuracy%20in%20differentiating%20malignant%20and%20benign%20lesions%20using%20single.pdf |
| _version_ | 1848846443151884288 |
|---|---|
| author | Suppiah, Subapriya Rahmat, Kartini Md Shah, Mohammad Nazri Che Ahmad, Azlan Tan, L. K. Abdul Aziz, Yang Faridah Vijayananthan, Anushya Wui, A. L. Yip, Cheng Har |
| author_facet | Suppiah, Subapriya Rahmat, Kartini Md Shah, Mohammad Nazri Che Ahmad, Azlan Tan, L. K. Abdul Aziz, Yang Faridah Vijayananthan, Anushya Wui, A. L. Yip, Cheng Har |
| author_sort | Suppiah, Subapriya |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | AIM: To investigate the diagnostic accuracy of single-voxel proton magnetic resonance spectroscopy (SV (1)H MRS) by quantifying total choline-containing compounds (tCho) in differentiating malignant from benign lesions, and subsequently, to analyse the relationship of tCho levels in malignant breast lesions with their histopathological subtypes.
MATERIALS AND METHODS: A prospective study of SV 1H MRS was performed following dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in 61 women using a 3 T MR system. All lesions (n = 57) were analysed for characteristics of morphology, contrast-enhancement kinetics, and tCho peak heights at SV (1)H MRS that were two-times above baseline. Subsequently, the tCho in selected lesions (n = 32) was quantified by calculating the area under the curve, and a tCho concentration equal to or greater than the cut-off value was considered to represent malignancy. The relationship between tCho in invasive ductal carcinomas (IDCs) and their Bloom & Richardson grading of malignancy was assessed.
RESULTS: Fifty-two patients (57 lesions; 42 malignant and 15 benign) were analysed. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), of predicting malignancy were 100, 73.3, 91.3, and 100%, respectively, using DCE-MRI and 95.2, 93.3, 97.6, and 87.5%, respectively, using SV (1)H MRS. The tCho cut-off for receiver operating characteristic (ROC) curve was 0.33 mmol/l. The relationship between tCho levels in malignant breast lesions with their histopathological subtypes was not statistically significant (p = 0.3).
CONCLUSION: Good correlation between tCho peaks and malignancy, enables SV (1)H MRS to be used as a clinically applicable, simple, yet non-invasive tool for improved specificity and diagnostic accuracy in detecting breast cancer. |
| first_indexed | 2025-11-15T09:02:47Z |
| format | Article |
| id | upm-29597 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:02:47Z |
| publishDate | 2013 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-295972016-09-14T08:16:58Z http://psasir.upm.edu.my/id/eprint/29597/ Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI Suppiah, Subapriya Rahmat, Kartini Md Shah, Mohammad Nazri Che Ahmad, Azlan Tan, L. K. Abdul Aziz, Yang Faridah Vijayananthan, Anushya Wui, A. L. Yip, Cheng Har AIM: To investigate the diagnostic accuracy of single-voxel proton magnetic resonance spectroscopy (SV (1)H MRS) by quantifying total choline-containing compounds (tCho) in differentiating malignant from benign lesions, and subsequently, to analyse the relationship of tCho levels in malignant breast lesions with their histopathological subtypes. MATERIALS AND METHODS: A prospective study of SV 1H MRS was performed following dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in 61 women using a 3 T MR system. All lesions (n = 57) were analysed for characteristics of morphology, contrast-enhancement kinetics, and tCho peak heights at SV (1)H MRS that were two-times above baseline. Subsequently, the tCho in selected lesions (n = 32) was quantified by calculating the area under the curve, and a tCho concentration equal to or greater than the cut-off value was considered to represent malignancy. The relationship between tCho in invasive ductal carcinomas (IDCs) and their Bloom & Richardson grading of malignancy was assessed. RESULTS: Fifty-two patients (57 lesions; 42 malignant and 15 benign) were analysed. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), of predicting malignancy were 100, 73.3, 91.3, and 100%, respectively, using DCE-MRI and 95.2, 93.3, 97.6, and 87.5%, respectively, using SV (1)H MRS. The tCho cut-off for receiver operating characteristic (ROC) curve was 0.33 mmol/l. The relationship between tCho levels in malignant breast lesions with their histopathological subtypes was not statistically significant (p = 0.3). CONCLUSION: Good correlation between tCho peaks and malignancy, enables SV (1)H MRS to be used as a clinically applicable, simple, yet non-invasive tool for improved specificity and diagnostic accuracy in detecting breast cancer. Elsevier 2013-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29597/1/Improved%20diagnostic%20accuracy%20in%20differentiating%20malignant%20and%20benign%20lesions%20using%20single.pdf Suppiah, Subapriya and Rahmat, Kartini and Md Shah, Mohammad Nazri and Che Ahmad, Azlan and Tan, L. K. and Abdul Aziz, Yang Faridah and Vijayananthan, Anushya and Wui, A. L. and Yip, Cheng Har (2013) Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI. Clinical Radiology, 68 (9). e502-e510. ISSN 0009-9260; ESSN: 1365-229X 10.1016/j.crad.2013.04.002 |
| spellingShingle | Suppiah, Subapriya Rahmat, Kartini Md Shah, Mohammad Nazri Che Ahmad, Azlan Tan, L. K. Abdul Aziz, Yang Faridah Vijayananthan, Anushya Wui, A. L. Yip, Cheng Har Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI |
| title | Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI |
| title_full | Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI |
| title_fullStr | Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI |
| title_full_unstemmed | Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI |
| title_short | Improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton MRS of the breast at 3 T MRI |
| title_sort | improved diagnostic accuracy in differentiating malignant and benign lesions using single-voxel proton mrs of the breast at 3 t mri |
| url | http://psasir.upm.edu.my/id/eprint/29597/ http://psasir.upm.edu.my/id/eprint/29597/ http://psasir.upm.edu.my/id/eprint/29597/1/Improved%20diagnostic%20accuracy%20in%20differentiating%20malignant%20and%20benign%20lesions%20using%20single.pdf |