Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr)
The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μ...
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| Format: | Article |
| Language: | English |
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Springer
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29592/ http://psasir.upm.edu.my/id/eprint/29592/1/Pathogenic%20Gram-positive%20bacteria%20are%20highly%20sensitive%20to%20triphenylphosphanegold%28O-alkylthiocarbamates%29%2C%20Ph3PAu%5BSC%28OR%29%3DN%28p-tolyl%29%5D%20%28R%E2%80%89%3D%E2%80%89Me%2C%20Et%20and%20iPr%29.pdf |
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| author | Yeo, Chien Ing Sim, Jiun Horng Khoo, Chai Hoon Goh, Zheng Jie Ang, Kok Pian Cheah, Yoke Kqueen Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R. T. |
| author_facet | Yeo, Chien Ing Sim, Jiun Horng Khoo, Chai Hoon Goh, Zheng Jie Ang, Kok Pian Cheah, Yoke Kqueen Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R. T. |
| author_sort | Yeo, Chien Ing |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μg/ml against four Gram-positive bacteria, namely Bacillus cereus, Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus; compounds 1–3 are less potent against a broad panel of 16 Gram-negative bacteria. As the minimum bactericidal concentration values were quite similar to the MIC values, compounds 1–3 are effective bactericidal agents. The specific action against the four Gram-positive bacteria suggests they function by inhibition of peptidoglycan synthesis. |
| first_indexed | 2025-11-15T09:02:46Z |
| format | Article |
| id | upm-29592 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:02:46Z |
| publishDate | 2013 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-295922016-07-12T08:38:10Z http://psasir.upm.edu.my/id/eprint/29592/ Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) Yeo, Chien Ing Sim, Jiun Horng Khoo, Chai Hoon Goh, Zheng Jie Ang, Kok Pian Cheah, Yoke Kqueen Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R. T. The phosphanegold(I) thiocarbamides, Ph3PAu{SC(OR)=NC6H4Me-4} for R = Me (1), Et (2) and iPr (3), have been shown to have essentially linear gold atom coordination geometries defined by phosphane-P and thiolate-S atoms, and exhibit minimum inhibitory concentration (MIC) values in the range of 1–37 μg/ml against four Gram-positive bacteria, namely Bacillus cereus, Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus; compounds 1–3 are less potent against a broad panel of 16 Gram-negative bacteria. As the minimum bactericidal concentration values were quite similar to the MIC values, compounds 1–3 are effective bactericidal agents. The specific action against the four Gram-positive bacteria suggests they function by inhibition of peptidoglycan synthesis. Springer 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29592/1/Pathogenic%20Gram-positive%20bacteria%20are%20highly%20sensitive%20to%20triphenylphosphanegold%28O-alkylthiocarbamates%29%2C%20Ph3PAu%5BSC%28OR%29%3DN%28p-tolyl%29%5D%20%28R%E2%80%89%3D%E2%80%89Me%2C%20Et%20and%20iPr%29.pdf Yeo, Chien Ing and Sim, Jiun Horng and Khoo, Chai Hoon and Goh, Zheng Jie and Ang, Kok Pian and Cheah, Yoke Kqueen and Fairuz, Zainal Abidin and Abdul Halim, Siti Nadiah and Ng, Seik Weng and Seng, Hoi Ling and Tiekink, Edward R. T. (2013) Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr). Gold Bulletin, 46 (3). pp. 145-152. ISSN 2364-821X; ESSN: 2190-7579 http://link.springer.com/article/10.1007/s13404-013-0091-z?view=classic 10.1007/s13404-013-0091-z |
| spellingShingle | Yeo, Chien Ing Sim, Jiun Horng Khoo, Chai Hoon Goh, Zheng Jie Ang, Kok Pian Cheah, Yoke Kqueen Fairuz, Zainal Abidin Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward R. T. Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) |
| title | Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) |
| title_full | Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) |
| title_fullStr | Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) |
| title_full_unstemmed | Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) |
| title_short | Pathogenic Gram-positive bacteria are highly sensitive to triphenylphosphanegold(O-alkylthiocarbamates), Ph3PAu[SC(OR)=N(p-tolyl)] (R = Me, Et and iPr) |
| title_sort | pathogenic gram-positive bacteria are highly sensitive to triphenylphosphanegold(o-alkylthiocarbamates), ph3pau[sc(or)=n(p-tolyl)] (r = me, et and ipr) |
| url | http://psasir.upm.edu.my/id/eprint/29592/ http://psasir.upm.edu.my/id/eprint/29592/ http://psasir.upm.edu.my/id/eprint/29592/ http://psasir.upm.edu.my/id/eprint/29592/1/Pathogenic%20Gram-positive%20bacteria%20are%20highly%20sensitive%20to%20triphenylphosphanegold%28O-alkylthiocarbamates%29%2C%20Ph3PAu%5BSC%28OR%29%3DN%28p-tolyl%29%5D%20%28R%E2%80%89%3D%E2%80%89Me%2C%20Et%20and%20iPr%29.pdf |