Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways

The synthesis and characterisation of R3PAu[S2CN(iPr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1–3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin....

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Main Authors: Jamaludin, Nazzatush Shimar, Goh, Zheng Jie, Cheah, Yoke Kqueen, Ang, Kok Pian, Sim, Jiun Horng, Khoo, Chai Hoon, Zainal Abidin, Mohd Fairuz, Abdul Halim, Siti Nadiah, Ng, Seik Weng, Seng, Hoi Ling, Tiekink, Edward Richard Tom
Format: Article
Published: Elsevier 2013
Online Access:http://psasir.upm.edu.my/id/eprint/29590/
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author Jamaludin, Nazzatush Shimar
Goh, Zheng Jie
Cheah, Yoke Kqueen
Ang, Kok Pian
Sim, Jiun Horng
Khoo, Chai Hoon
Zainal Abidin, Mohd Fairuz
Abdul Halim, Siti Nadiah
Ng, Seik Weng
Seng, Hoi Ling
Tiekink, Edward Richard Tom
author_facet Jamaludin, Nazzatush Shimar
Goh, Zheng Jie
Cheah, Yoke Kqueen
Ang, Kok Pian
Sim, Jiun Horng
Khoo, Chai Hoon
Zainal Abidin, Mohd Fairuz
Abdul Halim, Siti Nadiah
Ng, Seik Weng
Seng, Hoi Ling
Tiekink, Edward Richard Tom
author_sort Jamaludin, Nazzatush Shimar
building UPM Institutional Repository
collection Online Access
description The synthesis and characterisation of R3PAu[S2CN(iPr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1–3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis by 1, and necrosis by 2 and 3, are demonstrated, by both extrinsic and intrinsic pathways. Compound 1 activates the p53 gene, 2 activates only the p73 gene, whereas 3 activates both the p53 and p73 genes. Compounds 1 and 3 activate NF-κB, and each inhibits topoisomerase I.
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institution Universiti Putra Malaysia
institution_category Local University
last_indexed 2025-11-15T09:02:46Z
publishDate 2013
publisher Elsevier
recordtype eprints
repository_type Digital Repository
spelling upm-295902015-12-07T08:55:15Z http://psasir.upm.edu.my/id/eprint/29590/ Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways Jamaludin, Nazzatush Shimar Goh, Zheng Jie Cheah, Yoke Kqueen Ang, Kok Pian Sim, Jiun Horng Khoo, Chai Hoon Zainal Abidin, Mohd Fairuz Abdul Halim, Siti Nadiah Ng, Seik Weng Seng, Hoi Ling Tiekink, Edward Richard Tom The synthesis and characterisation of R3PAu[S2CN(iPr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1–3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis by 1, and necrosis by 2 and 3, are demonstrated, by both extrinsic and intrinsic pathways. Compound 1 activates the p53 gene, 2 activates only the p73 gene, whereas 3 activates both the p53 and p73 genes. Compounds 1 and 3 activate NF-κB, and each inhibits topoisomerase I. Elsevier 2013-09 Article PeerReviewed Jamaludin, Nazzatush Shimar and Goh, Zheng Jie and Cheah, Yoke Kqueen and Ang, Kok Pian and Sim, Jiun Horng and Khoo, Chai Hoon and Zainal Abidin, Mohd Fairuz and Abdul Halim, Siti Nadiah and Ng, Seik Weng and Seng, Hoi Ling and Tiekink, Edward Richard Tom (2013) Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways. European Journal of Medicinal Chemistry, 67. pp. 127-141. ISSN 0223-5234; ESSN: 1768-3254 http://www.sciencedirect.com/science/article/pii/S0223523413004066 10.1016/j.ejmech.2013.06.038
spellingShingle Jamaludin, Nazzatush Shimar
Goh, Zheng Jie
Cheah, Yoke Kqueen
Ang, Kok Pian
Sim, Jiun Horng
Khoo, Chai Hoon
Zainal Abidin, Mohd Fairuz
Abdul Halim, Siti Nadiah
Ng, Seik Weng
Seng, Hoi Ling
Tiekink, Edward Richard Tom
Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
title Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
title_full Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
title_fullStr Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
title_full_unstemmed Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
title_short Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
title_sort phosphanegold(i) dithiocarbamates, r3pau[sc(=s)n(ipr)ch2ch2oh] for r=ph, cy and et: role of phosphane-bound r substituents upon in vitro cytotoxicity against mcf-7r breast cancer cells and cell death pathways
url http://psasir.upm.edu.my/id/eprint/29590/
http://psasir.upm.edu.my/id/eprint/29590/
http://psasir.upm.edu.my/id/eprint/29590/