Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats
Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential ac...
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| Format: | Article |
| Language: | English |
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MDPI
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29585/ http://psasir.upm.edu.my/id/eprint/29585/1/Study%20on%20the%20potential%20toxicity%20of%20a%20thymoquinone.pdf |
| _version_ | 1848846440016642048 |
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| author | Tubesha, Zaki Imam, Mustapha Umar Mahmud, Rozi Ismail, Maznah |
| author_facet | Tubesha, Zaki Imam, Mustapha Umar Mahmud, Rozi Ismail, Maznah |
| author_sort | Tubesha, Zaki |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential acute toxicity of this nanoemulsion in Sprague Dawley rats. The acute toxicity studies were conducted as per the OECD guidelines 425, allowing for the use of test dose limit of 20 mL TQRFNE (containing 44.5 mg TQ)/kg. TQRFNE and distilled water (DW) as a control were administered orally to both sexes of rats on Day 0 and observed for 14 days. All the animals appeared normal, and healthy throughout the study. There was no observed mortality or any signs of toxicity during the experimental period. The effects of the TQRFNE and DW groups on general behavior, body weight, food and water consumption, relative organ weight, hematology, histopathology, and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control (DW) group. The administration of 20 mL TQRFNE /kg was not toxic after an acute exposure. |
| first_indexed | 2025-11-15T09:02:44Z |
| format | Article |
| id | upm-29585 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:02:44Z |
| publishDate | 2013 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-295852015-12-29T02:37:50Z http://psasir.upm.edu.my/id/eprint/29585/ Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats Tubesha, Zaki Imam, Mustapha Umar Mahmud, Rozi Ismail, Maznah Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential acute toxicity of this nanoemulsion in Sprague Dawley rats. The acute toxicity studies were conducted as per the OECD guidelines 425, allowing for the use of test dose limit of 20 mL TQRFNE (containing 44.5 mg TQ)/kg. TQRFNE and distilled water (DW) as a control were administered orally to both sexes of rats on Day 0 and observed for 14 days. All the animals appeared normal, and healthy throughout the study. There was no observed mortality or any signs of toxicity during the experimental period. The effects of the TQRFNE and DW groups on general behavior, body weight, food and water consumption, relative organ weight, hematology, histopathology, and clinical biochemistry were measured. All the parameters measured were unaffected as compared to the control (DW) group. The administration of 20 mL TQRFNE /kg was not toxic after an acute exposure. MDPI 2013-07 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29585/1/Study%20on%20the%20potential%20toxicity%20of%20a%20thymoquinone.pdf Tubesha, Zaki and Imam, Mustapha Umar and Mahmud, Rozi and Ismail, Maznah (2013) Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats. Molecules, 18 (7). pp. 7460-7472. ISSN 1420-3049 http://www.mdpi.com/1420-3049/18/7/7460 10.3390/molecules18077460 |
| spellingShingle | Tubesha, Zaki Imam, Mustapha Umar Mahmud, Rozi Ismail, Maznah Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats |
| title | Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats |
| title_full | Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats |
| title_fullStr | Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats |
| title_full_unstemmed | Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats |
| title_short | Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats |
| title_sort | study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in sprague dawley rats |
| url | http://psasir.upm.edu.my/id/eprint/29585/ http://psasir.upm.edu.my/id/eprint/29585/ http://psasir.upm.edu.my/id/eprint/29585/ http://psasir.upm.edu.my/id/eprint/29585/1/Study%20on%20the%20potential%20toxicity%20of%20a%20thymoquinone.pdf |