Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves
Context: Acanthopanax trifoliatus is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases. Aims: The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of Acanthopanax t...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer - Medknow Publications
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29530/ http://psasir.upm.edu.my/id/eprint/29530/1/Anti-inflammatory%20and%20anti-hyperalgesic%20acitivities%20of%20Acanthopanax%20trifoliatus%20%28L.%29%20Merr%20leaves.pdf |
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| author | Abd Hamid @ Abdul Razak, Roslida Teoh, Hui Kee Othman, Fezah |
| author_facet | Abd Hamid @ Abdul Razak, Roslida Teoh, Hui Kee Othman, Fezah |
| author_sort | Abd Hamid @ Abdul Razak, Roslida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Context: Acanthopanax trifoliatus is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases. Aims: The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of Acanthopanax trifoliatus leaves ethanolic extract in rats. Materials and Methods: Anti-inflammatory activity was studied by using carrageenan-induced edema on rat paw whilst anti-hyperalgesic was assessed by using carrageenan-evoked thermal hyperalgesia on plantar test. Statistical Analysis Used: Data were analyzed using Student t-test to compare with control.Multiple comparisons for difference between control and extract-treated groups were evaluated by Tukey HSD (Honestly Significant Difference) test. P values less than 0.05 (P < 0.05) is considered significant. Results: Among three different fractions i.e., hexane, dichloromethane, and methanol tested, methanolic fraction displayed the most potent fraction amongst those three. It gave significant anti-inflammatory effect at highest dose, 500 mg/kg, with 77.24% of inhibition. Whilst for anti-hyperalgesic activity, methanolic fraction showed the highest efficacy at 375 mg/kg. Administration of methanolic fraction of Acanthopanax trifoliatus inhibited paw edema in a dose- dependent manner. The inhibition for both activities might be due to possible composition of polar compounds, which are flavonoids and phenolics content. Conclusions: Methanol fraction of Acanthopanax trifoliatus leaves has potential effect as anti-inflammatory and anti-hyperalgesia in acute inflammation model. |
| first_indexed | 2025-11-15T09:02:29Z |
| format | Article |
| id | upm-29530 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T09:02:29Z |
| publishDate | 2013 |
| publisher | Wolters Kluwer - Medknow Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-295302016-10-31T02:14:54Z http://psasir.upm.edu.my/id/eprint/29530/ Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves Abd Hamid @ Abdul Razak, Roslida Teoh, Hui Kee Othman, Fezah Context: Acanthopanax trifoliatus is a ginseng-like plant, which has been widely used to treat various diseases including inflammatory-related diseases. Aims: The present study has been designed to investigate the anti-inflammatory and anti-hyperalgesic effects of various fractions of Acanthopanax trifoliatus leaves ethanolic extract in rats. Materials and Methods: Anti-inflammatory activity was studied by using carrageenan-induced edema on rat paw whilst anti-hyperalgesic was assessed by using carrageenan-evoked thermal hyperalgesia on plantar test. Statistical Analysis Used: Data were analyzed using Student t-test to compare with control.Multiple comparisons for difference between control and extract-treated groups were evaluated by Tukey HSD (Honestly Significant Difference) test. P values less than 0.05 (P < 0.05) is considered significant. Results: Among three different fractions i.e., hexane, dichloromethane, and methanol tested, methanolic fraction displayed the most potent fraction amongst those three. It gave significant anti-inflammatory effect at highest dose, 500 mg/kg, with 77.24% of inhibition. Whilst for anti-hyperalgesic activity, methanolic fraction showed the highest efficacy at 375 mg/kg. Administration of methanolic fraction of Acanthopanax trifoliatus inhibited paw edema in a dose- dependent manner. The inhibition for both activities might be due to possible composition of polar compounds, which are flavonoids and phenolics content. Conclusions: Methanol fraction of Acanthopanax trifoliatus leaves has potential effect as anti-inflammatory and anti-hyperalgesia in acute inflammation model. Wolters Kluwer - Medknow Publications 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29530/1/Anti-inflammatory%20and%20anti-hyperalgesic%20acitivities%20of%20Acanthopanax%20trifoliatus%20%28L.%29%20Merr%20leaves.pdf Abd Hamid @ Abdul Razak, Roslida and Teoh, Hui Kee and Othman, Fezah (2013) Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves. Pharmacognosy Research, 5 (2). pp. 129-133. ISSN 0976-4836; ESSN: 0974-8490 10.4103/0974-8490.110544 |
| spellingShingle | Abd Hamid @ Abdul Razak, Roslida Teoh, Hui Kee Othman, Fezah Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves |
| title | Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves |
| title_full | Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves |
| title_fullStr | Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves |
| title_full_unstemmed | Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves |
| title_short | Anti-inflammatory and anti-hyperalgesic acitivities of Acanthopanax trifoliatus (L.) Merr leaves |
| title_sort | anti-inflammatory and anti-hyperalgesic acitivities of acanthopanax trifoliatus (l.) merr leaves |
| url | http://psasir.upm.edu.my/id/eprint/29530/ http://psasir.upm.edu.my/id/eprint/29530/ http://psasir.upm.edu.my/id/eprint/29530/1/Anti-inflammatory%20and%20anti-hyperalgesic%20acitivities%20of%20Acanthopanax%20trifoliatus%20%28L.%29%20Merr%20leaves.pdf |