The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts.
Pathogenic bacteria communicate with small signal molecules in a process called quorum sensing, and they often use different signal molecules to regulate virulence gene expression. Vibrio campbellii, one of the major pathogens of aquatic organisms, regulates virulence gene expression by a three chan...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/29437/ http://psasir.upm.edu.my/id/eprint/29437/1/The%20Vibrio%20campbellii%20quorum%20sensing%20signals%20have%20a%20different%20impact%20on%20virulence%20of%20the%20bacterium%20towards%20different%20crustacean%20hosts.pdf |
| _version_ | 1848846399466110976 |
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| author | Julyantoro Pande, Gde Sasmita Mohd Ikhsan, Natrah Fatin Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom |
| author_facet | Julyantoro Pande, Gde Sasmita Mohd Ikhsan, Natrah Fatin Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom |
| author_sort | Julyantoro Pande, Gde Sasmita |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Pathogenic bacteria communicate with small signal molecules in a process called quorum sensing, and they often use different signal molecules to regulate virulence gene expression. Vibrio campbellii, one of the major pathogens of aquatic organisms, regulates virulence gene expression by a three channel quorum sensing system. Here we show that although they use a common signal transduction cascade, the signal molecules have a different impact on the virulence of the bacterium towards different hosts, i.e. the brine shrimp Artemia franciscana and the commercially important giant freshwater prawn Macrobrachium rosenbergii. These results suggest that the use of multiple types of signal molecules to regulate virulence gene expression is one of the features that allow bacteria to infect different hosts. Our findings emphasize that it is highly important to study the efficacy of quorum sensing inhibitors as novel biocontrol agents under conditions that are as close as possible to the clinical situation. |
| first_indexed | 2025-11-15T09:02:06Z |
| format | Article |
| id | upm-29437 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T09:02:06Z |
| publishDate | 2013 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-294372015-10-05T07:31:04Z http://psasir.upm.edu.my/id/eprint/29437/ The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. Julyantoro Pande, Gde Sasmita Mohd Ikhsan, Natrah Fatin Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom Pathogenic bacteria communicate with small signal molecules in a process called quorum sensing, and they often use different signal molecules to regulate virulence gene expression. Vibrio campbellii, one of the major pathogens of aquatic organisms, regulates virulence gene expression by a three channel quorum sensing system. Here we show that although they use a common signal transduction cascade, the signal molecules have a different impact on the virulence of the bacterium towards different hosts, i.e. the brine shrimp Artemia franciscana and the commercially important giant freshwater prawn Macrobrachium rosenbergii. These results suggest that the use of multiple types of signal molecules to regulate virulence gene expression is one of the features that allow bacteria to infect different hosts. Our findings emphasize that it is highly important to study the efficacy of quorum sensing inhibitors as novel biocontrol agents under conditions that are as close as possible to the clinical situation. Elsevier 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29437/1/The%20Vibrio%20campbellii%20quorum%20sensing%20signals%20have%20a%20different%20impact%20on%20virulence%20of%20the%20bacterium%20towards%20different%20crustacean%20hosts.pdf Julyantoro Pande, Gde Sasmita and Mohd Ikhsan, Natrah Fatin and Sorgeloos, Patrick and Bossier, Peter and Defoirdt, Tom (2013) The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. Veterinary Microbiology, 167 (3-4). pp. 540-545. ISSN 0378-1135; ESSN: 1873-2542 10.1016/j.vetmic.2013.08.021 English |
| spellingShingle | Julyantoro Pande, Gde Sasmita Mohd Ikhsan, Natrah Fatin Sorgeloos, Patrick Bossier, Peter Defoirdt, Tom The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. |
| title | The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. |
| title_full | The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. |
| title_fullStr | The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. |
| title_full_unstemmed | The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. |
| title_short | The Vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. |
| title_sort | vibrio campbellii quorum sensing signals have a different impact on virulence of the bacterium towards different crustacean hosts. |
| url | http://psasir.upm.edu.my/id/eprint/29437/ http://psasir.upm.edu.my/id/eprint/29437/ http://psasir.upm.edu.my/id/eprint/29437/1/The%20Vibrio%20campbellii%20quorum%20sensing%20signals%20have%20a%20different%20impact%20on%20virulence%20of%20the%20bacterium%20towards%20different%20crustacean%20hosts.pdf |