In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer
Mung bean has been reported to have antioxidant, cytotoxic, and immunomodulatory effects in vitro. Fermented products are reported to have enhanced immunomodulation and cancer chemopreventive effects. In this study, fermented mung bean treatments in vivo were studied by monitoring tumor development,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/28097/ http://psasir.upm.edu.my/id/eprint/28097/1/28097.pdf |
| _version_ | 1848846021985042432 |
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| author | Yeap, Swee Keong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Beh, Boon Kee Ho, Wan Yong Mohd Ali, Norlaily Mohammed Alitheen, Noorjahan Banu Koh, Soo Peng Long, Kamariah |
| author_facet | Yeap, Swee Keong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Beh, Boon Kee Ho, Wan Yong Mohd Ali, Norlaily Mohammed Alitheen, Noorjahan Banu Koh, Soo Peng Long, Kamariah |
| author_sort | Yeap, Swee Keong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mung bean has been reported to have antioxidant, cytotoxic, and immunomodulatory effects in vitro. Fermented products are reported to have enhanced immunomodulation and cancer chemopreventive effects. In this study, fermented mung bean treatments in vivo were studied by monitoring tumor development, spleen immunity, serum cytokine (interleukin 2 and interferon gamma) levels, and spleen/tumor antioxidant levels after injection with low and high risk 4T1 breast cancer cells. Pretreatment with fermented mung bean was associated with delayed tumor formation in low risk mice. Furthermore, this treatment was connected with higher serum anticancer cytokine levels, spleen T cell populations, splenocyte cytotoxicity, and spleen/tumor antioxidant levels. Histopathological evaluation of fermented mung bean treated tumor revealed lower event of mitotic division. On the other hand, antioxidant and nitric oxide levels that were significantly increased in the untreated mice were inhibited in the fermented mung bean treated groups. These results suggested that fermented mung bean has potential cancer chemoprevention effects through the stimulation of immunity, lipid peroxidation, and anti-inflammation. |
| first_indexed | 2025-11-15T08:56:06Z |
| format | Article |
| id | upm-28097 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:56:06Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-280972016-06-20T06:13:41Z http://psasir.upm.edu.my/id/eprint/28097/ In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer Yeap, Swee Keong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Beh, Boon Kee Ho, Wan Yong Mohd Ali, Norlaily Mohammed Alitheen, Noorjahan Banu Koh, Soo Peng Long, Kamariah Mung bean has been reported to have antioxidant, cytotoxic, and immunomodulatory effects in vitro. Fermented products are reported to have enhanced immunomodulation and cancer chemopreventive effects. In this study, fermented mung bean treatments in vivo were studied by monitoring tumor development, spleen immunity, serum cytokine (interleukin 2 and interferon gamma) levels, and spleen/tumor antioxidant levels after injection with low and high risk 4T1 breast cancer cells. Pretreatment with fermented mung bean was associated with delayed tumor formation in low risk mice. Furthermore, this treatment was connected with higher serum anticancer cytokine levels, spleen T cell populations, splenocyte cytotoxicity, and spleen/tumor antioxidant levels. Histopathological evaluation of fermented mung bean treated tumor revealed lower event of mitotic division. On the other hand, antioxidant and nitric oxide levels that were significantly increased in the untreated mice were inhibited in the fermented mung bean treated groups. These results suggested that fermented mung bean has potential cancer chemoprevention effects through the stimulation of immunity, lipid peroxidation, and anti-inflammation. Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/28097/1/28097.pdf Yeap, Swee Keong and Mohd Yusof, Hamidah and Mohamad, Nurul Elyani and Beh, Boon Kee and Ho, Wan Yong and Mohd Ali, Norlaily and Mohammed Alitheen, Noorjahan Banu and Koh, Soo Peng and Long, Kamariah (2013) In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer. Evidence-Based Complementary and Alternative Medicine, 2013. art. no. 708464. pp. 1-7. ISSN 1741-427X; ESSN: 1741-4288 http://www.hindawi.com/journals/ecam/2013/708464/abs/ 10.1155/2013/708464 |
| spellingShingle | Yeap, Swee Keong Mohd Yusof, Hamidah Mohamad, Nurul Elyani Beh, Boon Kee Ho, Wan Yong Mohd Ali, Norlaily Mohammed Alitheen, Noorjahan Banu Koh, Soo Peng Long, Kamariah In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer |
| title | In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer |
| title_full | In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer |
| title_fullStr | In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer |
| title_full_unstemmed | In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer |
| title_short | In vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer |
| title_sort | in vivo immunomodulation and lipid peroxidation activities contributed to chemoprevention effects of fermented mung bean against breast cancer |
| url | http://psasir.upm.edu.my/id/eprint/28097/ http://psasir.upm.edu.my/id/eprint/28097/ http://psasir.upm.edu.my/id/eprint/28097/ http://psasir.upm.edu.my/id/eprint/28097/1/28097.pdf |