Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage
Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective e...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://psasir.upm.edu.my/id/eprint/28008/ http://psasir.upm.edu.my/id/eprint/28008/1/28008.pdf |
| _version_ | 1848845996101992448 |
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| author | Mohd Ali, Norlaily Mohd Yusof, Hamidah Long, Kamariah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Koh, Soo Peng Abdullah, Mohd Puad Mohammed Alitheen, Noorjahan Banu |
| author_facet | Mohd Ali, Norlaily Mohd Yusof, Hamidah Long, Kamariah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Koh, Soo Peng Abdullah, Mohd Puad Mohammed Alitheen, Noorjahan Banu |
| author_sort | Mohd Ali, Norlaily |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dried mung bean and amino-acid- and GABA-enriched germinated and fermented mung bean aqueous extracts were compared. Liver superoxide dismutase (SOD), malondialdehyde (MDA), ferric reducing antioxidant power (FRAP), nitric oxide (NO) levels, and serum biochemical profile such as aspartate transaminase (AST), alanine transaminase (ALT), triglycerides (TG), and cholesterol and histopathological changes were examined for the antioxidant and hepatoprotective effects of these treatments. Germinated and fermented mung bean have recorded an increase of 27.9 and 7.3 times of GABA and 8.7 and 13.2 times of amino acid improvement, respectively, as compared to normal mung bean. Besides, improvement of antioxidant levels, serum markers, and NO level associated with better histopathological evaluation indicated that these extracts could promote effective recovery from hepatocyte damage. These results suggested that freeze-dried, germinated, and fermented mung bean aqueous extracts enriched with amino acids and GABA possessed better hepatoprotective effect as compared to normal mung bean. |
| first_indexed | 2025-11-15T08:55:41Z |
| format | Article |
| id | upm-28008 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:55:41Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-280082016-03-07T05:06:05Z http://psasir.upm.edu.my/id/eprint/28008/ Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage Mohd Ali, Norlaily Mohd Yusof, Hamidah Long, Kamariah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Koh, Soo Peng Abdullah, Mohd Puad Mohammed Alitheen, Noorjahan Banu Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dried mung bean and amino-acid- and GABA-enriched germinated and fermented mung bean aqueous extracts were compared. Liver superoxide dismutase (SOD), malondialdehyde (MDA), ferric reducing antioxidant power (FRAP), nitric oxide (NO) levels, and serum biochemical profile such as aspartate transaminase (AST), alanine transaminase (ALT), triglycerides (TG), and cholesterol and histopathological changes were examined for the antioxidant and hepatoprotective effects of these treatments. Germinated and fermented mung bean have recorded an increase of 27.9 and 7.3 times of GABA and 8.7 and 13.2 times of amino acid improvement, respectively, as compared to normal mung bean. Besides, improvement of antioxidant levels, serum markers, and NO level associated with better histopathological evaluation indicated that these extracts could promote effective recovery from hepatocyte damage. These results suggested that freeze-dried, germinated, and fermented mung bean aqueous extracts enriched with amino acids and GABA possessed better hepatoprotective effect as compared to normal mung bean. Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/28008/1/28008.pdf Mohd Ali, Norlaily and Mohd Yusof, Hamidah and Long, Kamariah and Yeap, Swee Keong and Ho, Wan Yong and Beh, Boon Kee and Koh, Soo Peng and Abdullah, Mohd Puad and Mohammed Alitheen, Noorjahan Banu (2013) Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage. BioMed Research International, 2013. art. no. 693613. pp. 1-9. ISSN 2314-6133; ESSN: 2314-6141 http://www.hindawi.com/journals/bmri/2013/693613/abs/ 10.1155/2013/693613 |
| spellingShingle | Mohd Ali, Norlaily Mohd Yusof, Hamidah Long, Kamariah Yeap, Swee Keong Ho, Wan Yong Beh, Boon Kee Koh, Soo Peng Abdullah, Mohd Puad Mohammed Alitheen, Noorjahan Banu Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage |
| title | Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage |
| title_full | Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage |
| title_fullStr | Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage |
| title_full_unstemmed | Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage |
| title_short | Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage |
| title_sort | antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage |
| url | http://psasir.upm.edu.my/id/eprint/28008/ http://psasir.upm.edu.my/id/eprint/28008/ http://psasir.upm.edu.my/id/eprint/28008/ http://psasir.upm.edu.my/id/eprint/28008/1/28008.pdf |