Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques.
Due to the lack of scientific investigation on Dysoxylum grande, chemical investigation on this plant icthyotoxic leaves was done. Thorough fractionation using various chromatographic techniques including High Performance Liquid Chromatography (HPLC) has led to the isolation and characterization of...
| Main Authors: | , |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
2012
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/27331/ http://psasir.upm.edu.my/id/eprint/27331/1/ID%2027331.pdf |
| _version_ | 1848845816178933760 |
|---|---|
| author | Ismail, Intan Safinar Low, K. W. |
| author_facet | Ismail, Intan Safinar Low, K. W. |
| author_sort | Ismail, Intan Safinar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Due to the lack of scientific investigation on Dysoxylum grande, chemical investigation on this plant icthyotoxic leaves was done. Thorough fractionation using various chromatographic techniques including High Performance Liquid Chromatography (HPLC) has led to the isolation and characterization of eight new triterpenoids. The new compounds were named as grandol A(1), B(2), C(3), D(4), E(5), F(6) and G(7)H. Another compound having a different configuration at C24 was assign as the new 20S, 24R0epoxy-7b, 25-dihydroxy-34-secodammar-4(28)-en-3-oic acid (8). All compounds were elucidated based on various spectroscopic data. Their relative configuration was established by 2D NMR data of NOESY. All compounds were tested for anti-acetylcholinesterase using Thin Layer Chromatography (TLC)-bioautography with fast blue B salt. Only grandol A91) and B(2) showed positive results with clear discoloration until at the concentration of 12.5 ppm. However, the obtained IC50 for both grandol A and B when using Ellman's method, was not significant (>200ug/ml) compared to galanthamine (1.955 ug/ml) or huperzine A (0.082 ug/ml[1,2] |
| first_indexed | 2025-11-15T08:52:49Z |
| format | Conference or Workshop Item |
| id | upm-27331 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:52:49Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-273312014-04-08T09:22:33Z http://psasir.upm.edu.my/id/eprint/27331/ Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques. Ismail, Intan Safinar Low, K. W. Due to the lack of scientific investigation on Dysoxylum grande, chemical investigation on this plant icthyotoxic leaves was done. Thorough fractionation using various chromatographic techniques including High Performance Liquid Chromatography (HPLC) has led to the isolation and characterization of eight new triterpenoids. The new compounds were named as grandol A(1), B(2), C(3), D(4), E(5), F(6) and G(7)H. Another compound having a different configuration at C24 was assign as the new 20S, 24R0epoxy-7b, 25-dihydroxy-34-secodammar-4(28)-en-3-oic acid (8). All compounds were elucidated based on various spectroscopic data. Their relative configuration was established by 2D NMR data of NOESY. All compounds were tested for anti-acetylcholinesterase using Thin Layer Chromatography (TLC)-bioautography with fast blue B salt. Only grandol A91) and B(2) showed positive results with clear discoloration until at the concentration of 12.5 ppm. However, the obtained IC50 for both grandol A and B when using Ellman's method, was not significant (>200ug/ml) compared to galanthamine (1.955 ug/ml) or huperzine A (0.082 ug/ml[1,2] 2012 Conference or Workshop Item NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/27331/1/ID%2027331.pdf Ismail, Intan Safinar and Low, K. W. (2012) Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques. In: 8th International Symposium on Chromatography of Natural Products, 17-20 May 2012, Lublin, Poland. . English |
| spellingShingle | Ismail, Intan Safinar Low, K. W. Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques. |
| title | Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques.
|
| title_full | Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques.
|
| title_fullStr | Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques.
|
| title_full_unstemmed | Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques.
|
| title_short | Eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques.
|
| title_sort | eight new triterpenoids isolated from dysoxylum grande (meliaceae) by various chromatographic techniques. |
| url | http://psasir.upm.edu.my/id/eprint/27331/ http://psasir.upm.edu.my/id/eprint/27331/1/ID%2027331.pdf |