A Simple and Clean Method for Methoxymethylation of Phenols
A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperatur...
| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
1989
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| Online Access: | http://psasir.upm.edu.my/id/eprint/2614/ http://psasir.upm.edu.my/id/eprint/2614/1/A_Simple_and_Clean_Method_for_Methoxymethylation_of_Phenols.pdf |
| _version_ | 1848839296459472896 |
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| author | Ahmad, Faujan Bruce, Malcolm J. |
| author_facet | Ahmad, Faujan Bruce, Malcolm J. |
| author_sort | Ahmad, Faujan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having
internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with
a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis(
methoxymethoxy)benzaldehyde (2) in 57% yield; under similar conditions, the methoxymethyl ether (6) of
salicylaldehyde was isolated in 75% yield. Yields of61-81 %, not optimised, of methoxymethyl ethers of several
phenols lacking internal hydrogen bonding were also obtained. |
| first_indexed | 2025-11-15T07:09:12Z |
| format | Article |
| id | upm-2614 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:09:12Z |
| publishDate | 1989 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-26142013-05-27T07:02:17Z http://psasir.upm.edu.my/id/eprint/2614/ A Simple and Clean Method for Methoxymethylation of Phenols Ahmad, Faujan Bruce, Malcolm J. A simple and clean procedure for the preparation of methoxymethyl ethers (MOM = CH2 OMe) of phenols having internally hydrogen bonded hydroxy groups is described. Thus treatment of 2,5-dihydroxybenzaldehyde (1) with a 1:1 mixture of methoxymethyl chloride-methyl acetate in ether at room temperature gives 2.5-bis( methoxymethoxy)benzaldehyde (2) in 57% yield; under similar conditions, the methoxymethyl ether (6) of salicylaldehyde was isolated in 75% yield. Yields of61-81 %, not optimised, of methoxymethyl ethers of several phenols lacking internal hydrogen bonding were also obtained. 1989 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/2614/1/A_Simple_and_Clean_Method_for_Methoxymethylation_of_Phenols.pdf Ahmad, Faujan and Bruce, Malcolm J. (1989) A Simple and Clean Method for Methoxymethylation of Phenols. Pertanika, 12 (1). pp. 71-78. English |
| spellingShingle | Ahmad, Faujan Bruce, Malcolm J. A Simple and Clean Method for Methoxymethylation of Phenols |
| title | A Simple and Clean Method for Methoxymethylation of Phenols |
| title_full | A Simple and Clean Method for Methoxymethylation of Phenols |
| title_fullStr | A Simple and Clean Method for Methoxymethylation of Phenols |
| title_full_unstemmed | A Simple and Clean Method for Methoxymethylation of Phenols |
| title_short | A Simple and Clean Method for Methoxymethylation of Phenols |
| title_sort | simple and clean method for methoxymethylation of phenols |
| url | http://psasir.upm.edu.my/id/eprint/2614/ http://psasir.upm.edu.my/id/eprint/2614/1/A_Simple_and_Clean_Method_for_Methoxymethylation_of_Phenols.pdf |