Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models
AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform fo...
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| Format: | Article |
| Language: | English |
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The Pharmaceutical Society of Japan
2006
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25549/ http://psasir.upm.edu.my/id/eprint/25549/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20effects%20of%20Solanum%20nigrum%20chloroform%20extract%20in%20animal%20models.pdf |
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| author | Zakaria, Zainul Amiruddin Gopalan, Hanan Kumar Zainal, Hairani Mohd Pojan, Nur Hidayu Morsid, Nur Atiqah Aris, Anwariah Sulaiman, Mohd Roslan |
| author_facet | Zakaria, Zainul Amiruddin Gopalan, Hanan Kumar Zainal, Hairani Mohd Pojan, Nur Hidayu Morsid, Nur Atiqah Aris, Anwariah Sulaiman, Mohd Roslan |
| author_sort | Zakaria, Zainul Amiruddin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40°C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (s.c.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited significant (p<0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (p<0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims. |
| first_indexed | 2025-11-15T08:45:14Z |
| format | Article |
| id | upm-25549 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:45:14Z |
| publishDate | 2006 |
| publisher | The Pharmaceutical Society of Japan |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-255492016-10-10T03:43:17Z http://psasir.upm.edu.my/id/eprint/25549/ Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models Zakaria, Zainul Amiruddin Gopalan, Hanan Kumar Zainal, Hairani Mohd Pojan, Nur Hidayu Morsid, Nur Atiqah Aris, Anwariah Sulaiman, Mohd Roslan AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40°C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (s.c.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited significant (p<0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (p<0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims. The Pharmaceutical Society of Japan 2006 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25549/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20effects%20of%20Solanum%20nigrum%20chloroform%20extract%20in%20animal%20models.pdf Zakaria, Zainul Amiruddin and Gopalan, Hanan Kumar and Zainal, Hairani and Mohd Pojan, Nur Hidayu and Morsid, Nur Atiqah and Aris, Anwariah and Sulaiman, Mohd Roslan (2006) Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models. Yakugaku Zasshi, 126 (11). pp. 1171-1178. ISSN 0031-6903; ESSN: 1347-5231 https://www.jstage.jst.go.jp/article/yakushi/126/11/126_11_1171/_article 10.1248/yakushi.126.1171 |
| spellingShingle | Zakaria, Zainul Amiruddin Gopalan, Hanan Kumar Zainal, Hairani Mohd Pojan, Nur Hidayu Morsid, Nur Atiqah Aris, Anwariah Sulaiman, Mohd Roslan Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models |
| title | Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models |
| title_full | Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models |
| title_fullStr | Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models |
| title_full_unstemmed | Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models |
| title_short | Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models |
| title_sort | antinociceptive, anti-inflammatory and antipyretic effects of solanum nigrum chloroform extract in animal models |
| url | http://psasir.upm.edu.my/id/eprint/25549/ http://psasir.upm.edu.my/id/eprint/25549/ http://psasir.upm.edu.my/id/eprint/25549/ http://psasir.upm.edu.my/id/eprint/25549/1/Antinociceptive%2C%20anti-inflammatory%20and%20antipyretic%20effects%20of%20Solanum%20nigrum%20chloroform%20extract%20in%20animal%20models.pdf |