Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
This study probes into the prospect of cross-reactivity of HCMV with RCMV which has not been acknowledged to date. We describe the uncovering of a protein with an estimated size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera. Our findings are a first disclosure of...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Parasitology and Tropical Medicine
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25420/ http://psasir.upm.edu.my/id/eprint/25420/1/Cross-reactivity%20of%20Malaysian%20rat%20cytomegalovirus%20strains%20with%20its%20human%20counterpart.pdf |
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| author | Camalxaman, Siti Nazrina Allaudin, Zeenathul Nazariah Quah, Yi Wan Loh, Hwei San Hassan, Zuridah Abdul Rahman, Sheikh Omar Mohd Lila, Mohd Azmi |
| author_facet | Camalxaman, Siti Nazrina Allaudin, Zeenathul Nazariah Quah, Yi Wan Loh, Hwei San Hassan, Zuridah Abdul Rahman, Sheikh Omar Mohd Lila, Mohd Azmi |
| author_sort | Camalxaman, Siti Nazrina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study probes into the prospect of cross-reactivity of HCMV with RCMV which has not been acknowledged to date. We describe the uncovering of a protein with an estimated size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera. Our findings are a first disclosure of a plausible immunological cross-reactivity between RCMV with its human counterpart which grounds substantial interest implying existence of conserved determinants between rat and human CMV polypeptides. The cross-reactive protein most likely represents an enveloped glycoprotein, though the precise identification and its degree of similarity needs to be evidently defined and further elucidated in forthcoming experiments. |
| first_indexed | 2025-11-15T08:44:42Z |
| format | Article |
| id | upm-25420 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:44:42Z |
| publishDate | 2011 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-254202019-10-30T01:08:37Z http://psasir.upm.edu.my/id/eprint/25420/ Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart Camalxaman, Siti Nazrina Allaudin, Zeenathul Nazariah Quah, Yi Wan Loh, Hwei San Hassan, Zuridah Abdul Rahman, Sheikh Omar Mohd Lila, Mohd Azmi This study probes into the prospect of cross-reactivity of HCMV with RCMV which has not been acknowledged to date. We describe the uncovering of a protein with an estimated size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera. Our findings are a first disclosure of a plausible immunological cross-reactivity between RCMV with its human counterpart which grounds substantial interest implying existence of conserved determinants between rat and human CMV polypeptides. The cross-reactive protein most likely represents an enveloped glycoprotein, though the precise identification and its degree of similarity needs to be evidently defined and further elucidated in forthcoming experiments. Malaysian Society of Parasitology and Tropical Medicine 2011-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/25420/1/Cross-reactivity%20of%20Malaysian%20rat%20cytomegalovirus%20strains%20with%20its%20human%20counterpart.pdf Camalxaman, Siti Nazrina and Allaudin, Zeenathul Nazariah and Quah, Yi Wan and Loh, Hwei San and Hassan, Zuridah and Abdul Rahman, Sheikh Omar and Mohd Lila, Mohd Azmi (2011) Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart. Tropical Biomedicine, 28 (3). pp. 661-667. ISSN 0127-5720 http://msptm.org/journal-vol-28-no-3/ |
| spellingShingle | Camalxaman, Siti Nazrina Allaudin, Zeenathul Nazariah Quah, Yi Wan Loh, Hwei San Hassan, Zuridah Abdul Rahman, Sheikh Omar Mohd Lila, Mohd Azmi Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart |
| title | Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart |
| title_full | Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart |
| title_fullStr | Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart |
| title_full_unstemmed | Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart |
| title_short | Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart |
| title_sort | cross-reactivity of malaysian rat cytomegalovirus strains with its human counterpart |
| url | http://psasir.upm.edu.my/id/eprint/25420/ http://psasir.upm.edu.my/id/eprint/25420/ http://psasir.upm.edu.my/id/eprint/25420/1/Cross-reactivity%20of%20Malaysian%20rat%20cytomegalovirus%20strains%20with%20its%20human%20counterpart.pdf |