Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80
Nanostructured lipid carriers (NLC), a colloidal carrier system offer many advantages as drug carrier. Incorporation of liquid lipid can improve the loading capacity of drugs in the NLCs. The NLC20 and NLC80 were produced by high-pressure homogenization technique, stabilized with polysorbate 20 and...
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| Format: | Article |
| Language: | English |
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Academic Journals
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25349/ http://psasir.upm.edu.my/id/eprint/25349/1/25349.pdf |
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| author | How, Chee Wun Abdullah, Rasedee Abbasalipourkabirreh, Roghayeh |
| author_facet | How, Chee Wun Abdullah, Rasedee Abbasalipourkabirreh, Roghayeh |
| author_sort | How, Chee Wun |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nanostructured lipid carriers (NLC), a colloidal carrier system offer many advantages as drug carrier. Incorporation of liquid lipid can improve the loading capacity of drugs in the NLCs. The NLC20 and NLC80 were produced by high-pressure homogenization technique, stabilized with polysorbate 20 and polysorbate 80, respectively. Transmission electron microscopy showed that these NLCs were spherical. Photon correlation spectroscopy showed that the average size of NLC80 and NLC20 were 102.8 ± 0.1 and 261.63 ± 8.56 nm, respectively, and their zeta potentials were -23.93 ± 0.75 and -30.57 ± 0.06 mV, respectively. The results suggest that NLC80 is a more stable formulation. X-ray diffractometry and differential scanning calorimetry showed that NCLs were less crystalline than the bulk lipid. The melting point depression of NLC80 was 5.71°C below bulk lipid’s melting point (61.56°C), while NLC20 exhibited two melting points at 54.80 and 59.10°C. These findings suggest that polysorbate 80 was a better dispersing agent for NLC than polysorbate 20. The physicochemistry properties of the NLCs are greatly influenced by the type of surfactant used. The small size and superior particle surface to volume ratio would increase loading efficiency and bioavailability of drugs, thus making NLC a promising drug delivery system. |
| first_indexed | 2025-11-15T08:44:24Z |
| format | Article |
| id | upm-25349 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T08:44:24Z |
| publishDate | 2011 |
| publisher | Academic Journals |
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| spelling | upm-253492016-04-27T08:16:06Z http://psasir.upm.edu.my/id/eprint/25349/ Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 How, Chee Wun Abdullah, Rasedee Abbasalipourkabirreh, Roghayeh Nanostructured lipid carriers (NLC), a colloidal carrier system offer many advantages as drug carrier. Incorporation of liquid lipid can improve the loading capacity of drugs in the NLCs. The NLC20 and NLC80 were produced by high-pressure homogenization technique, stabilized with polysorbate 20 and polysorbate 80, respectively. Transmission electron microscopy showed that these NLCs were spherical. Photon correlation spectroscopy showed that the average size of NLC80 and NLC20 were 102.8 ± 0.1 and 261.63 ± 8.56 nm, respectively, and their zeta potentials were -23.93 ± 0.75 and -30.57 ± 0.06 mV, respectively. The results suggest that NLC80 is a more stable formulation. X-ray diffractometry and differential scanning calorimetry showed that NCLs were less crystalline than the bulk lipid. The melting point depression of NLC80 was 5.71°C below bulk lipid’s melting point (61.56°C), while NLC20 exhibited two melting points at 54.80 and 59.10°C. These findings suggest that polysorbate 80 was a better dispersing agent for NLC than polysorbate 20. The physicochemistry properties of the NLCs are greatly influenced by the type of surfactant used. The small size and superior particle surface to volume ratio would increase loading efficiency and bioavailability of drugs, thus making NLC a promising drug delivery system. Academic Journals 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25349/1/25349.pdf How, Chee Wun and Abdullah, Rasedee and Abbasalipourkabirreh, Roghayeh (2011) Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80. African Journal of Biotechnology, 10 (9). art. no. 1F6873B28763. pp. 1684-1689. ISSN 1684–5315 http://www.academicjournals.org/journal/AJB/article-abstract/1F6873B28763 |
| spellingShingle | How, Chee Wun Abdullah, Rasedee Abbasalipourkabirreh, Roghayeh Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 |
| title | Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 |
| title_full | Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 |
| title_fullStr | Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 |
| title_full_unstemmed | Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 |
| title_short | Physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 |
| title_sort | physicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80 |
| url | http://psasir.upm.edu.my/id/eprint/25349/ http://psasir.upm.edu.my/id/eprint/25349/ http://psasir.upm.edu.my/id/eprint/25349/1/25349.pdf |