Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin.
New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P − 1, Z = 2, V = 612.92(3) Å3 and unit cell parameters a = 6.8540(2) Å, b = 8.3022(2...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Springer Verlag
2012
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25258/ http://psasir.upm.edu.my/id/eprint/25258/1/Synthesis%2C%20characterisation.pdf |
| _version_ | 1848845259852742656 |
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| author | Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkin, David J. |
| author_facet | Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkin, David J. |
| author_sort | Abdul Manan, Mohd Abdul Fatah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P − 1, Z = 2, V = 612.92(3) Å3 and unit cell parameters a = 6.8540(2) Å, b = 8.3022(2) Å, c = 11.5243(4) Å, α = 79.8186(13)°, β = 90.5224(14)° and γ = 72.1362(13)°. Crystal structure reveals that the compound exists in the thione form with the methylisatin moiety is trans with respect to the C3–N2 and C3–S4 bonds whereas the methyl group of the dithiocarbazate moiety is cis with respect to the C3–N2 and C3–S5 bonds. The Schiff base was found to be selectively active against the selected Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) with the inhibition zones of 16 and 12 mm, respectively. |
| first_indexed | 2025-11-15T08:43:59Z |
| format | Article |
| id | upm-25258 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:43:59Z |
| publishDate | 2012 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-252582015-09-23T06:32:08Z http://psasir.upm.edu.my/id/eprint/25258/ Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkin, David J. New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P − 1, Z = 2, V = 612.92(3) Å3 and unit cell parameters a = 6.8540(2) Å, b = 8.3022(2) Å, c = 11.5243(4) Å, α = 79.8186(13)°, β = 90.5224(14)° and γ = 72.1362(13)°. Crystal structure reveals that the compound exists in the thione form with the methylisatin moiety is trans with respect to the C3–N2 and C3–S4 bonds whereas the methyl group of the dithiocarbazate moiety is cis with respect to the C3–N2 and C3–S5 bonds. The Schiff base was found to be selectively active against the selected Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) with the inhibition zones of 16 and 12 mm, respectively. Springer Verlag 2012-02 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25258/1/Synthesis%2C%20characterisation.pdf Abdul Manan, Mohd Abdul Fatah and Mohamed Tahir, Mohamed Ibrahim and Crouse, Karen Anne and How, Fiona Ni Foong and Watkin, David J. (2012) Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. Journal of Chemical Crystallography, 42 (2). pp. 173-179. ISSN 1074-1542; ESSN:1572-8854 10.1007/s10870-011-0220-6 English |
| spellingShingle | Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne How, Fiona Ni Foong Watkin, David J. Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. |
| title | Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. |
| title_full | Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. |
| title_fullStr | Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. |
| title_full_unstemmed | Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. |
| title_short | Synthesis, characterisation and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin. |
| title_sort | synthesis, characterisation and antibacterial activity of schiff base derived from s-methyldithiocarbazate and methylisatin. |
| url | http://psasir.upm.edu.my/id/eprint/25258/ http://psasir.upm.edu.my/id/eprint/25258/ http://psasir.upm.edu.my/id/eprint/25258/1/Synthesis%2C%20characterisation.pdf |