Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate.
A new tridentate nitrogen–sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallogr...
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| Format: | Article |
| Language: | English English |
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Springer
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25247/ http://psasir.upm.edu.my/id/eprint/25247/1/Synthesis%2C%20characterization%20and%20bioactivity%20of%20mixed-ligand%20Cu%28II%29%20.pdf |
| _version_ | 1848845256712257536 |
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| author | Ravoof, Thahira Begum S A Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Rosli, Rozita Watkin, David John How, Fiona Ni Foong |
| author_facet | Ravoof, Thahira Begum S A Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Rosli, Rozita Watkin, David John How, Fiona Ni Foong |
| author_sort | Ravoof, Thahira Begum S A |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A new tridentate nitrogen–sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor). |
| first_indexed | 2025-11-15T08:43:56Z |
| format | Article |
| id | upm-25247 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T08:43:56Z |
| publishDate | 2011 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-252472015-10-30T07:46:21Z http://psasir.upm.edu.my/id/eprint/25247/ Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. Ravoof, Thahira Begum S A Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Rosli, Rozita Watkin, David John How, Fiona Ni Foong A new tridentate nitrogen–sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor). Springer 2011-04 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/25247/1/Synthesis%2C%20characterization%20and%20bioactivity%20of%20mixed-ligand%20Cu%28II%29%20.pdf Ravoof, Thahira Begum S A and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Rosli, Rozita and Watkin, David John and How, Fiona Ni Foong (2011) Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. Journal of Chemical Crystallography, 41 (4). pp. 491-495. ISSN 1074-1542; ESSN:1572-8854 10.1007/s10870-010-9907-3 English |
| spellingShingle | Ravoof, Thahira Begum S A Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Rosli, Rozita Watkin, David John How, Fiona Ni Foong Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. |
| title | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. |
| title_full | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. |
| title_fullStr | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. |
| title_full_unstemmed | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. |
| title_short | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. |
| title_sort | synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene) hydrazinecarbodithioate. |
| url | http://psasir.upm.edu.my/id/eprint/25247/ http://psasir.upm.edu.my/id/eprint/25247/ http://psasir.upm.edu.my/id/eprint/25247/1/Synthesis%2C%20characterization%20and%20bioactivity%20of%20mixed-ligand%20Cu%28II%29%20.pdf |